Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Integrating Structures in Physiology
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:05 pm
"Structure of RyR2 Channels Reveals a Mechanism for Exercise-Induced Sudden Death and it's Treatment"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Fat Chances: How Signaling Lipids Influence Lysosomal pH via the Chloride Transporter ClC-7"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Defective X-gating caused by de novo gain-of-function mutations in KCNK3 underlies a developmental disorder with sleep apnea"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Twenty-Five Years of the Sodium/Iodide Symporter (NIS): From its Cloning to..."
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Regulation of Potassium/Proton Symporter KimA by Second Messenger Cyclic Di-AMP"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"An Intracellular Hydrophobic Nexus is Critical for Slow Deactivation in hERG Channels"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Prestin’s Conformational Cycle and the Molecular Basis of Electromotility in Outer Hair Cells"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Structure of the Shaker Kv Channel and Mechanism of C-Type Inactivation"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Molecular Origins and Principles Governing Adrenaline Efficacy and Potency in the Human ß2-Adrenergic Receptor"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Cellular Machineries in Adaptive Immunity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Novel Approaches to Investigate Membrane Protein Structure and Function
6:00 pm - 6:20 pm
"Novel Engineering Strategies and Structural and Mechanistic Insights into GPCRs"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"The Structural and Molecular Composition of Native AMPA Receptor Complexes"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Decoding the Language of Aromatic Side-Chains in Ion Channels and Receptors"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Deconvoluting Membrane Protein Trafficking, Folding, and Function by Multi-Parametric Mutational Scanning"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"19F NMR Maps Conformational Ensembles of Membrane Transporters"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Structural Insights in Membrane Protein Function
9:00 am - 9:20 am
"Structural Snapshots of TRPV1 in Response to Stimuli"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"The Conformational Heterogeneity of a Human Neutral Amino Acid Transporter"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Molecular Basis of Lipid-Mediated GPCR Activation"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Transport and Receptor Mechanisms of a Solute Carrier"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Structural Mechanisms of Ligand Regulation in KATP Channels"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Structure of the Core Human Phagocytic NADPH Oxidase NOX2"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Curious Case of the Human Sodium Leak Channel"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Pathophysiology of Membrane Transport and Signaling
6:00 pm - 6:20 pm
"Coordinated Biogenesis and Regulation of Functionally Related Ion Channels"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Drug Transport and Modulation of ABCG2 Activity by 2nd Generation of Ko143 Derivatives"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Ligand and Lipid Modulation in Cyclic Nucleotide-Gated Channels"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Cryo-EM Structures of CALHM Channels of the Human Placenta"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Role of the SLC7A5 Transporter in Cortical Neuron Maturation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein-Membrane Interactions
9:00 am - 9:20 am
"Hydrophobicity Along the Z-Dimension of the Bilayer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Substrate Specify vs. Promiscuity in the Small Multidrug Resistance Family of Transporters"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Structure and Function of Autoregulatory Mechanisms of P-Type ATPases"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Force Transduction in Piezo Ion Channels"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
"Cryo-EM Structure and Resistance Landscape of M. tuberculosis MmpL3: An Emergent Therapeutic Target"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanism of Cell Wall Transporters Involved in Teichoic Acids Synthesis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"How Small Molecules Improve CFTR Folding"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Automated Patch Clamp and Antivenom Discovery"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Unleashing the Power of Enhanced Molecular Dynamics Simulations and Artificial Intelligence for Structure-Based Drug Discovery"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Identification of HCN1 allosteric sites for small molecule modulation"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"TRPV Channels Gating by Endogenous and Exogenous Modulators"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Mechanisms of Activation and Regulation of Metabotropic Glutamate Receptors"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Allosteric regulation of KtrAB by nucleotides"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Conformational Sampling of Sugar Porters"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Site-Specific Tryptophan Fluorescence Distinguishes Drug-Binding to Distinct Sites of the Multidrug Exporter P-Glycoprotein"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"A Through the Looking Glass View of Voltage-Gated Ion Channel Structure"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"TRPV2 Intrinsically Disordered Regions (IDRs) mediate Protein-Protein Interactions"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Molecular Insights into Serotonin-2A Receptor Signaling"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Structural Basis of Ionotropic Glutamate Receptor Gating and Allosteric Modulation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Structural Basis of Colibactin Activation by the ClbP Peptidase"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Structure and Function of Membrane Adenylyl Cyclases"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Structure and Mechanism of the Cation/Proton Antiporter Complex MRP"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Molecular Mechanisms Underlying Omega-3 Fatty Acid Uptake Across the Blood-Brain Barrier"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure