Conference Description
The Ligand Recognition and Molecular Gating GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.
The topic of this GRC is unique, as it addresses the structures, functional mechanisms and higher-order assemblies of three important classes of transmembrane proteins: ion channels, active transporters, and G-protein coupled receptors (GPCRs). In this edition of the GRC, we aim to modernize and direct the focus to current frontiers in the field, such as the study of the structure, function and interaction of these proteins with lipids, with partner proteins, in super-complexes, and ultimately in a cellular context. New structural methods such as cryo-electron tomography and native-mass spectrometry of vesicles or cellular compartments combined with computational approaches now allow to acquire an integrated structural characterization of these protein classes, while advanced single-molecule techniques allow to unravel kinetics and energetics avoiding ensemble averaging.
The topics, speakers, and discussion leaders for the conference sessions are displayed below. The conference chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by November 15, 2025. Please check back for updates.
Keynote Session: Mesoscale Membrane Biology
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Regulation of Transporter/Channel/Receptor Activity through Proteinprotein Interaction
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Modulation of Protein Activity by Lipids and Small Molecules
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Transporters, Channels and Receptors in Bacterial Resistance
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Proteins that are Natural Chimera
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Promises & Challenges of Cryo-EM
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Supercomplexes: Membrane Proteins that Form Functional Ensembles
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Structural Pharmacology
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Late Breaking Findings in the Channel/Receptor/Transporter Field
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