Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mesoscale Membrane Biology
7:40 pm - 8:10 pm
"Ligand and Lipid Recognition in Membrane Receptors and Transporters"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Short Talk Selected from Poster Abstracts
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Molecular Simulations Capture Membrane Proteins in Action"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modulation of Protein Activity by Lipids and Small Molecules
9:00 am - 9:20 am
"Gatekeepers of Phosphate Homeostasis: Unveiling the Unconventional Mechanisms of its Transporters"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Dynamic control of a human glutamate transporter"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Lipid Modulation of CNG Channels: A Tale of Inhibition and Activation"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Nucleotide and Dinucleotide Sensing in a Mycobacterial K+ Channel"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Chemical Specificity in the Olfactory System"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Regulation of Transporter, Channel and Receptor Activity through Protein-Protein Interaction
6:00 pm - 6:20 pm
"Not Alone: Protein-Protein Interactions between Ion Channels and Endogenous or de novo Designed Proteins"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Lipid Transport at Membrane Contact Sites by the IST2-OSH6 Complex"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Oh HECT! Ion Channel Regulation by HECT E3 Ligases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transporters, Channels and Receptors in Bacterial Resistance
9:00 am - 9:20 am
"Siderophore Import and Export in Mycobacteria"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Membrane Transporters in Out-of-Equilibrium Reaction Networks of Synthetic Cells"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Transporting Proteins across the Bacterial Membranes - Proton driven Mechanisms"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanistic Basis of Transport Processes involved in the Biosynthesis of Cell Wall Polymers"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Mechanisms of Inhibition of a Lipid Flippase"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Membrane Proteins that are Natural Chimera
6:00 pm - 6:20 pm
"Making Order out of Disorder: Role of Intrinsically Disordered Regions in KATP Channels"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Light at the End of the Channel - Cryo-EM Snapshots of Light-Induced Activation in Naturally Occurring Rhodopsin-Channel Fusions from Antarctica"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"The mTORC1 Cholesterol-Sensing Protein LYCHOS is a GPCR–PIN Transporter Hybrid"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Promises & Challenges of Cryo-EM for Studying Membrane Protein Mechanisms of Action
9:00 am - 9:20 am
"Activation of RyR1 in Native Membranes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Temperature Reshapes TRPM4 Pharmacology"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Molecular Basis of Force Transduction in Prestin"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Unexpected MOAs of Toxins on Nav Channels"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Supercomplexes: Membrane Proteins that Form Functional Ensembles
6:00 pm - 6:20 pm
"The Hidden Architecture of Red Blood Cells: Native Complexes Revealed by Cryo-EM"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Unlocking the Gateway to Chloroplast Protein Import"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Molecular Insights into Activation and Signaling of Non-Canonical GPCRs"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:20 am
"Mechanistic Framework of Ligand Efficacy at a G Protein-Coupled Receptor"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Data Science Approaches to GPCR Signaling: Implications for Physiology and Drug Development"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Unlocking the Molecular Mechanism of Amino Acid Transport and Inhibition"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanisms of RXFP1 Relaxin Receptor Activation by Diverse Agonists"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Structural Mechanisms of Gating in ENaC/DEG Channels"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Concepts in the Channel / Receptor / Transporter Field
6:00 pm - 6:20 pm
"Elucidating the Molecular Regulation of Dopamine Transporter Activity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Short Talk Selected from Poster Abstracts
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"Structural Insights into the Generation of Lipid Asymmetry in the Endoplasmic Reticulum"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Short Talk Selected from Poster Abstracts
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Structural Investigation of Human M-Channel"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure