- 7:15-7:25 - Site Director's Welcome
- 7:25-7:30 - William L. Smith, Michigan State University - Opening Remarks
Discussion Leader, David L. DeWitt
- 7:30 - Peter Isakson, Searle/Monsanto - "Cyclooxygenase 2 in inflammation and pain"
- 8:05 - David L. DeWitt, Michigan State University - "Subcellular compartmentation of prostaglandin biosynthetic enzymes"
- 8:40 - Ronald Evans, Scripps Research Institute - "Nuclear receptors as targets for eicosanoids"
- 9:15 - L. Jackson Roberts, Vanderbilt University - "Products of non-enzymatic lipid peroxidation: The isoprostanes and related compounds"
Discussion Leader, Alfred H. Merrill, Jr.
- 8:30 - Alfred H. Merrill, Jr., Emory University School of Medicine - "Sphingolipid metabolism and disease"
- 9:10 - Lina M. Obeid, Duke University Medical Center - "Ceramide in growth regulation: Apoptosis and senescence"
- 9:50 - Sarah Spiegel, Georgetown University - "Opposing effects of ceramide and sphingosine-1-phosphate on cell death and survival"
- 10:30 - Coffee Break
- 10:50 - Gerrit van Meer, Utrecht University Medical School - "Sphingolipids: Sites of synthesis and transmembrane translocation"
- 11:30 - Yohio Hirabayashi, The Institute of Physical and Chemical Research (RIKEN) - "Biological significance of modification in ceramide by glycosyltransferases"
Monday Afternoon: Poster Session I
NUCLEAR COMPARTMENTATION OF LIPID METABOLISM
Discussion Leader, Claudia Kent
- 7:30 - Claudia Kent, University of Michigan Medical School - "Regulating phosphatidylcholine biosynthesis: In the nucleus and where else?"
- 8:10 - Daniel Raben, Johns Hopkins University - "PC metabolism in nest nuclear envelope signal transduction"
- 8:50 - Marc L. Peters-Golden, University of Michigan Medical School - "The nucleus as an intracellular site for 5-lipoxygenase localization and action"
- 9:30 - Matt Topham, University of Utah - "Nuclear Targeting of Diacylglycerol Kinase Zeta"
PI KINASES AND PROTEIN BINDING DOMAINS FOR PHOSPHOINOSITIDES
Discussion Leader, John D. York
- 8:30 - Paul Sigler, Yale University - "PH domains: Structure, function, and more general implications"
- 9:20 - Lewis T. (Rusty) Williams, Chiron - "Mediation of growth factor signals by lipid kinases and phosphatases"
- 10:10 - Coffee Break
- 10:30 - John D. York, Duke University Medical Center - "Inositol 5-phosphatases: functional clues from studies in the yeast saccharomyces cerevisiae"
- 11:20 - Lewis Cantley, Harvard Institute of Medicine - "PI 3-kinase"
Tuesday Afternoon - Poster Session II
PHOSPHOLIPASES A, C, AND D
Discussion Leader, Edward Dennis
- 7:30 - Edward A. Dennis, University of California, San Diego - "Distinct role for each phospholipase A2 in signal transduction"
- 8:05 - Andrew Morris, SUNY Stony Brook - "Structure and regulation of phospholipase D"
- 8:40 - Roger L. Williams, MRC Centre, Cambridge, UK - "Structural studies of mammalian phosphoinositide-specific phosphalipase C"
- 9:15 - Hiroyuki Arai, University of Tokyo - "Structure and function of intra-cellular PAF-acetylhydrolase"
METABOLISM OF UNSATURATED FATTY ACIDS
Discussion Leader, Horst Schulz
- 8:30 - Howard Sprecher, Ohio State University - "Microsomal-peroxisomal interactions in regulating unsaturated fatty acid metabolism"
- 9:10 - John Shanklin, Brookhaven - "Structure-function studies on fatty acid desaturase and related hydroxylases"
- 9:50 - Guy P. Mannaerts, Katholieke Universiteit Leuven - "Function and organization of peroxisomal ß-oxidation"
- 10:30 - Coffee Break
- 10:50 - Daniel M. Lane, Johns Hopkins University - "Transcriptional Control of Adipocyte Differentiation"
- 11:30 - Robert C. Murphy, National Jewish Center - "In vitro Metabolism of LTB4: A polyunsaturated hydroxy acid lipid mediator of inflammation."
Discussion Leader, Steve Prescott
- 7:30 - Henk van den Bosch - "Alkyl-dihydroxyacetonephosphate Synthase, the Committed Peroxisomal Enzyme for Ether Lipid Biosynthesis"
- 8:05 - Jerold J. M. Chun, University of California, San Diego - "A Cloned LPA Receptor through Studies on Brain Development"
- 8:40 - Charles N. Serhan, Harvard Medical School - "Lipid-derived 'Stop Signals' in Human Leukocytes"
- 9:15 - Takao Shimizu, University of Tokyo
ACYL TRANSFERASES, TRANSACYLASES, LIPID TRANSPORT
Discussion Leader, Floyd B. Chilton
- 8:30 - Hei Sook Sul, University of California, Berkeley - "Mitochondrial Glycerol-3-phosphate Acyltransferase"
- 9:10 - Denis McGarry, University of Texas Southwestern Medical School - "The mitochondrial carnitine palmitoyl transferase system - an update"
- 9:50 - Floyd B. Chilton, Bowman-Gray Medical School - "The role of phospholipid remodeling in cell function"
- 10:30 - Coffee Break
- 10:50 - Vytas A. Bankaitis, University of Alabama, Birmingham - "Mechanisms of phosphatidylinositol transfer protein function in eukaryotes"
- 11:30 - Dennis Voelker, National Jewish Hospital, Denver - "Biochemical and genetic analysis of intracellular lipid transport"
LIPID MODIFICATIONS OF PROTEINS
Discussion Leader, W. Robert Bishop
- 7:30 - John Silvius, McGill University - "Physical and biochemical bases of intracellular targeting of lipid-modified proteins"
- 8:20 - Maurine Linder, Washington University - "Protein palmitoylation and G-Protein signalling"
- 9:10 - W. Robert Bishop, Schering Plough - "Effects of farnesyl transferase inhibitors on protein prenylation and cellular transformation"