Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Harnessing Biological Complexity in the Lung
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:30 pm
"Reserve Airway Stem Cell Compartment with Enhanced Regenerative Capacity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Human vs Mouse: Species Differences in Lung Development"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Sex as a Biological Variable in Lung Injury and Repair"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Early Lung Development: From Bench to Bedside
9:00 am - 9:25 am
"Molecular Basis of Tracheal Mesenchyme Patterning"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Genetic Mechanisms of Congenital Diaphragmatic Hernia"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Epigenomic Analysis of Sox9+ Lung Epithelial Progenitor Cell Specification Defines New Transcriptional Regulatory Networks in Lung Development"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Non-Coding RNA Control of Lung Alveologenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Indicators and Treatable Traits in Neonatal Chronic Lung Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Yap Nucleocytoplasmic Shuttling Is Crucial for Regulation of Region-Specific Developmental Programs in the Lung Epithelium"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Spatiotemporal Lineage Mapping to Define Molecular Crossroads of Heart Versus Lung Mesodermal Fate"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Pulmonary Vasculature: Influential Conduits of Development, Injury and Repair
7:30 pm - 7:55 pm
"Lung Lymphatics Play Important Roles in Resolution of Injury"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"The Role of Vascular Permeability in Pulmonary Fibrosis"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Transcriptional Mechanisms of Lung Endothelial Regeneration and Endothelial Heterogeneity"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"B1 Integrin Regulates Alveolar Homeostasis Through Alveolar Epithelial Cell Inflammatory Signaling"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Identification of Transcriptional Regulators Critical for Re-Programming of Normal Lung Endothelial Cells into Fibrosis-Promoting Endothelial Cells in IPF"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Terminal Bronchiole as a Specialized Transitional Lung Niche
9:00 am - 9:25 am
"Tissue Injury and Repair in Human Lungs"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Traversing the Wall: Signaling Across the Basement Membrane in Airway Regeneration"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Maternal Oxysterol Plays a Critical Role in Fetal Lung Alveolarization"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Human Distal Airways in Lung Injury Following Smoke Exposure and Allergic Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Early Postnatal Establishment of the Alveolar Epithelial Niche"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"An Ex Vivo Microfluidic Neonatal Lung Model to Visualize and Quantify the Dynamics of Alveolar Morphogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Transcriptional Networks Regulating Multiciliogenesis in the Mammalian Airway"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Small Populations of Lung Cells with Big Impact
7:30 pm - 7:55 pm
"Consider the Lung as a Sensory Organ"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Influenza-Induced Tuft Cells: Friend, Foe or Frenemy?"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"The Role of Susceptible Airway Epithelial Cells in COPD"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"High Resolution Evaluation of Human Airway Cell Diversity Towards Understanding the Cellular Composition and Function of the Distal Human Airways"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:25 pm
"Interrogating Transcriptional Networks in Alveolar Epithelial Progenitor Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Epithelial Adaptation Shaping Lung Niches
9:00 am - 9:25 am
"Epithelial Cell Unjamming in Airway Injury, Repair and Regeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"What an Ultrathin Cell Can Do: Structural and Signaling Roles of the Lung Alveolar Type 1 Cell"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Microvesicle Expression of Growth Hormone Receptor from Mesenchymal Cells Supports the Lung Epithelial Stem Cell Niche and Abrogates Pulmonary Fibrosis in Mice"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Vascular Niche Regulation of Lung Regeneration and Fibrosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Exosomes in Lung Development and Injury"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"GATA3 Regulation of Cldn1 in Basal Cells of the Human Airway Epithelium"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Cell RNA Sequencing Identifies Conserved Inflammatory Airspace Macrophage Subsets in Mice and Humans"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
The Role of the Extracellular Matrix in Establishing and Maintaining Lung Regions
7:30 pm - 7:55 pm
"The Triple Helix of Collagens: An Ancient Structure Enabling Tissue Adaptation"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"The Matrix Drives Aberrant Repair Responses in Chronic Lung Diseases"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Supramolecular Complex of Collagen IV and Proteoglycans Within Developing Basement Membrane"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Multi-Omics Analysis of Extracellular Niche Composition and Dynamic Changes During Lung Regeneration and Fibrosis Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Hyaluronan Synthase 3-Expressing Macrophages Drive Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Combined Pulmonary Fibrosis and Emphysema (CPFE)"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Regional and Temporal Mesenchymal Cell Identity
9:00 am - 9:25 am
"Location, Location, Location! Unique Stromal Neighborhoods Influence Differentiation and Maintenance of the Kidney"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"PDGF-A: Is There a Role in the Adult Lung"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Tcf21 Signaling in Lipofibroblast and Airway Development"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Mesenchymal Hedgehog Signaling: Expected and Unexpected Effects During Postnatal Lung Growth"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Relevant Immune Mechanisms for Estrogen-Mediated Pulmonary Fibrosis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Hyperoxia Injury of Saccular Stage Lung Results in Increased Mesenchymal Expression of Wnt5a that Is Driven by Upregulated Nf-kB Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Myofibroblast Contraction Is Essential for Generating and Regenerating the Gas-Exchange Surface"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Aging and Senescence in Shaping the Lung Across the Lifespan
7:30 pm - 8:00 pm
"The Lung Microenvironment Drives Immune Responses to Pathogens and Particles During Aging"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"Glutaminase 1 and NAD-Dependent Deacetylase SIRT7 Regulate TGF-β Mediated Pulmonary Fibrosis"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Circadian Rhythms in the Lung: A Life Course Perspective"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Senescent Cells as a Driver of Aging and Their Mitigation"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure