Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Orchestrating Cellular Differentiation to Shape the Lung
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
"Lung Fibroblast Heterogeneity in Health and Disease"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:00 pm
"Regulation of Lung Epithelial Repair by Mitochondrial Calcium Uptake"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Transcriptomic Profiling of Lung Tissue from Active and Recovered SARS-CoV-2 Infections "
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Formation and Remodeling of Lung Vasculature in Health and Disease
9:00 am - 9:30 am
"United in Diversity: Cellular Changes in Pulmonary Vascular Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Endothelial Cell Atlas of the Lung"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Fatty Acid-Binding Proteins Control Endothelial Cells Glycolysis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Group Photo / Coffee Break
11:05 am - 11:35 am
"Lung Mesenchymal Vascular Progenitors Modulate Adaptive Angiogenesis and Tissue Remodeling"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Role of Endothelial S1PR1 Signaling in Respiratory Viral Induced ARDS and Fibroproliferation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Dysfunctional ERG Signaling Drives Pulmonary Vascular Aging and Progressive Fibrosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cigarette Smoke Causes Lung Lymphatic Dysfunction and Thrombosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Diversity of Fibroblasts and Their Roles in Health and Disease
7:30 pm - 8:00 pm
"Functional Heterogeneity of Fibroblasts in Alveologenesis and Asthma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"GPI-Anchored Cell-Surface Proteins Distinguish Fibroblast Subsets and Their Integrin Activity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Reducing Fibroblast Persistence in Pulmonary Fibrosis as a Mechanism of Resolution"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Severe Influenza Virus Infection Induces Persistent Fibroblast Activation Associated with Prolonged Respiratory Distress"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Immunology in Lung Injury and Repair
9:00 am - 9:40 am
"Fibroblastic Cell Lineages in Scarring and Regeneration"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"CD8 T Cells and Lung Sequelae Post Viral Infection"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Mast Cells and Chronic Lung Disease of Prematurity"
11:30 am - 11:40 am
Discussion
11:40 am - 12:05 pm
"Epigenetic Control of the Pro-Lung Recovery Functions of Regulatory T Cells"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Macrophage-Fibroblast Interactions Contribute to Collagen Expression and Lung Remodeling During Pulmonary Fibrosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Targets, Tools and Strategies in Lung Repair
7:30 pm - 7:55 pm
"Multi-Faceted Lung Stem Cell Dynamics at Single Cell Resolution"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"The Epithelial Transitional Cell State in Physiologic and Pathologic Alveolar Regeneration"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Recreating Pulmonary Vasculature from iPSCs for Disease Modeling and Drug Development"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Reconstitution of the Injured Lung Epithelium via Transplantation of iPSC Derived Lung Progenitors"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lung Injury and Chronic Sequelae
9:00 am - 9:40 am
"Alveolar Injury and the Development of Post COVID Fibrosis"
9:40 am - 9:50 am
Discussion
9:50 am - 10:10 am
"E-Cigarette and Vaping Associated Lung Inflammation and Injury: Mechanisms and Outcomes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Dopamine Synthesis and D1 Receptor Agonism Are Essential for Resolution of Experimental Lung Fibrosis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:35 am
"The Journey of Alveolar Regeneration Directed by Niches"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Loss of Mitochondrial Adenine Nucleotide Translocase 2 (Ant2) in Alveolar Epithelial Cells Worsens Emphysema Through Cellular Senescence in a Mouse Model of COPD"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Microrna Let-7 Orchestrates Lung Inflammation and COPD or IPF-Like Disease in an Intrinsic Manner in T Cells and Epithelial Alveolar Type II Cells (AT2) in Mice"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Gut-Lung Axis Influences the Development of Bronchopulonary Dysplasia"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Epithelial Injury and Functional Regeneration
7:30 pm - 8:10 pm
"Lung Regeneration: A Tale of Mice and Men"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:50 pm
"Redirecting Growth Factor Signaling for Lung Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Building Epithelial Barrier in Whole-Lung Tissue Engineering"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lung Development and Its Lessons for Repair
9:00 am - 9:45 am
"Building the Human Lung: Lessons from Organoids"
9:45 am - 9:55 am
Discussion
9:55 am - 10:05 am
"Transcriptional Characterization Suggests Accelerated Epithelial Differentiation in Trisomy 21 Lungs"
10:05 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:10 am
"Metaplastic Alveolar Basal Cells in IPF Arise from AT2 Cells Through Aberrant Mesenchyme Signaling"
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Manipulating Neural Circuits as a Strategy to Control Lung Functio"
11:30 am - 11:35 am
Discussion
11:35 am - 12:05 pm
"Lung Stem Cells and Their Niches"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Intrinsic Lung and Respiratory System Changes in Mouse Models of Osteogenesis Imperfecta"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Bridging Discovery to Therapy
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
"Patient-Specific iPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:20 pm
"FGF Signaling in Hypoxia-Induced Pulmonary Hypertension"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
"Developing Novel Therapeutic Approaches for Treatment of Alveolar Capillary Dysplasia and Bronchopulmonary Dysplasia"
9:10 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure