Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: New Model Systems to Study Lung Development, Aging and Regeneration
7:40 pm - 8:10 pm
"Cell-Cell Interactions Regulating Lung Progenitor Cells"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Crystal Ribcage: A Platform for Probing Real-Time Lung Function at Cellular Resolution"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Lung Morphogenesis Across the Tree of Life"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vasculature in the Pathobiology and Repair of Chronic Lung Disease
9:00 am - 9:25 am
"Novel Models for Blood Vessel Repair and Angiogenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Inflammatory Control of Occlusive Artery Lesion Formation in a Mouse Model of Pulmonary Hypertension: The Role of T Cell Subsets"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Mitochondrial ASIC1a as a Key Regulator of Pulmonary Arterial Smooth Muscle Cell Apoptosis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Lung Endothelial miR-205-5p: A Key Driver of Pro-Fibrotic Signaling and Remodeling in Pulmonary Fibrosis"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mastering Fate: Mechanistic Insights into the Cell State Transition of Pulmonary Artery Smooth Muscle Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Biology-Based Maps of Cell States and Fates in Aging or Diseased Lungs
6:00 pm - 6:20 pm
"Isolation and Characterziation of Human Alveolar Stem Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Systems Biology-Based Maps of Aging and Injured Lungs"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Short Talk Selected from Poster Abstracts
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Glutathione-Dependent Protein Oxidation Controls Alveolar Type 2 Epithelial Cell Plasticity"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Modeling and Treating Pulmonary Fibrosis with Induced Pluripotent Stem Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular Architects: Redesigning the Fibrogenic Blueprint of Aberrant Lung Repair
9:00 am - 9:25 am
"Heterogeneity of Lung Fibroblasts in Health and Disease"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Cellular Interactions in Idiopathic Pulmonary Fibrosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Alveolar Epithelial Dysfunction as a Targetable Driver of Pulmonary Fibrosis"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Short Talk Selected from Poster Abstracts
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Discovering Pathways to Combat Dysregulated Tissue Repair"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromatin and Epigenetic Regulation of Lung Development and Disease
6:00 pm - 6:20 pm
"Genetics and Epigenetics of COPD Risk"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Chromatin State in Normal and Malignant Alveolar Regeneration"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Short Talk Selected from Poster Abstracts
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Epigenetic Mechanism of Vascular Remodeling and Targeted Therapies in Cardiopulmonary Diseases"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Human Pulmonary Fibrosis as a a Natural Laboratory for Epithelial Plasticity, Memory, and Injury Response"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Loss of the Alveolar-Capillary Unit in Development and Aging
9:00 am - 9:25 am
"Mechanisms of Airway Differentiation in Human Lung Development"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Two Faces of Beta Catenin in Alveolar Capillary Homeostasis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Vascular Cross-Talk in Lung Homeostasis, Aging, and Regeneration"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"More Than Just a Wrap: The Multiple Talents of the Mesothelium"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Adult Consequences of Perinatal Lung Injury: Evidence from Preclinical Studies"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Spanning Inflammation and Restoration: Immune Influences on Lung Regeneration
6:00 pm - 6:25 pm
"Promoting Lung Recovery: Epigenetic and Metabolic Control of Regulatory T Cell Function"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Thrombin Receptor Signaling in the Lung Lymphatic Vasculature: Novel Roles for an Old Vascular Pathway"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Short Talk Selected from Poster Abstracts
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Immune Mechanisms Drive the Transitional Cell State in Aberrant Lung Repair"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"The Dichotomy of Tumor Control by Recruited and Resident Tumor-Associated Macrophages"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanisms of Chronic Lung Disease in the Aging Lung
9:00 am - 9:25 am
"Immune and Structural Cell Crosstalk in Regulation of Lung Fibrosis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mitochondria Dysfunction and Senescence at the Spotlight of Lung Aging and Fibrosis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Systemic and Local Determinants of Age-Related Lung Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"A Thermodynamics-Inspired View of Lung Aging and Regeneration"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Alveolar Type 2 Cell Rejuvenation as a Window into Reversing Pulmonary Fibrosis and Promoting Lung Healthspan"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Linking the Rare to Repair: Identifying the Targetable Genes and Pathways that Drive Uncommon Lung Diseases
6:00 pm - 6:20 pm
"Identification of Disease Mechanisms in Alpha-1 Antitrypsin Deficiency-Associated Emphysema"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Epithelial Progenitors Predict Lung Cancer Regression"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Gene and Cell Therapies for Childhood Interstitial Lung Diseases and Bronchopulmonary Dysplasia"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Neurocrest Cells Drive TSC and LAM Tumorigenesis"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Tbx4 Mutation Drives Defective Alveolarization and PH, Driven by Aberrant Pericyte-Endothelial Interaction"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure