Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: New Model Systems to Study Lung Development, Aging and Regeneration
7:40 pm - 8:10 pm
"Cell-Cell Interactions Regulating Lung Progenitor Cells"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Crystal Ribcage: A Platform for Probing Real-Time Lung Function at Cellular Resolution"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Lung Morphogenesis Across the Tree of Life"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vasculature in the Pathobiology and Repair of Chronic Lung Disease
9:00 am - 9:25 am
"Novel Models for Blood Vessel Repair and Angiogenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Inflammatory Control of Occlusive Artery Lesion Formation in a Mouse Model of Pulmonary Hypertension: The Role of T Cell Subsets"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Mitochondrial ASIC1a as a Key Regulator of Pulmonary Arterial Smooth Muscle Cell Apoptosis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Lung Endothelial miR-205-5p: A Key Driver of Pro-Fibrotic Signaling and Remodeling in Pulmonary Fibrosis"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Short Talk Selected from Poster Abstracts
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mastering Fate: Mechanistic Insights into the Cell State Transition of Pulmonary Artery Smooth Muscle Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Biology-Based Maps of Cell States and Fates in Aging or Diseased Lungs
6:00 pm - 6:20 pm
"Isolation and Characterziation of Human Alveolar Stem Cells"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Systems Biology-Based Maps of Aging and Injured Lungs"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Short Talk Selected from Poster Abstracts
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Glutathione-Dependent Protein Oxidation Controls Alveolar Type 2 Epithelial Cell Plasticity"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Modeling and Treating Pulmonary Fibrosis with Induced Pluripotent Stem Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Cellular Architects: Redesigning the Fibrogenic Blueprint of Aberrant Lung Repair
9:00 am - 9:25 am
"Heterogeneity of Lung Fibroblasts in Health and Disease"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Cellular Interactions in Idiopathic Pulmonary Fibrosis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Short Talk Selected from Poster Abstracts
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
"Alveolar Epithelial Dysfunction as a Targetable Driver of Pulmonary Fibrosis"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
Short Talk Selected from Poster Abstracts
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Discovering Pathways to Combat Dysregulated Tissue Repair"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Chromatin and Epigenetic Regulation of Lung Development and Disease
6:00 pm - 6:20 pm
"Genetics and Epigenetics of COPD Risk"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Chromatin State in Normal and Malignant Alveolar Regeneration"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:00 pm
Short Talk Selected from Poster Abstracts
7:00 pm - 7:05 pm
Discussion
7:05 pm - 7:25 pm
"Epigenetic Mechanism of Vascular Remodeling and Targeted Therapies in Cardiopulmonary Diseases"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Human Pulmonary Fibrosis as a a Natural Laboratory for Epithelial Plasticity, Memory, and Injury Response"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Loss of the Alveolar-Capillary Unit in Development and Aging
9:00 am - 9:25 am
"Mechanisms of Airway Differentiation in Human Lung Development"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Two Faces of Beta Catenin in Alveolar Capillary Homeostasis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Vascular Cross-Talk in Lung Homeostasis, Aging, and Regeneration"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"More Than Just a Wrap: The Multiple Talents of the Mesothelium"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Adult Consequences of Perinatal Lung Injury: Evidence from Preclinical Studies"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Systems Spanning Inflammation and Restoration: Immune Influences on Lung Regeneration
6:00 pm - 6:25 pm
"Promoting Lung Recovery: Epigenetic and Metabolic Control of Regulatory T Cell Function"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Thrombin Receptor Signaling in the Lung Lymphatic Vasculature: Novel Roles for an Old Vascular Pathway"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Short Talk Selected from Poster Abstracts
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Immune Mechanisms Drive the Transitional Cell State in Aberrant Lung Repair"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"The Dichotomy of Tumor Control by Recruited and Resident Tumor-Associated Macrophages"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Mechanisms of Chronic Lung Disease in the Aging Lung
9:00 am - 9:25 am
"Immune and Structural Cell Crosstalk in Regulation of Lung Fibrosis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mitochondria Dysfunction and Senescence at the Spotlight of Lung Aging and Fibrosis"
9:50 am - 9:55 am
Discussion
9:55 am - 10:05 am
Short Talk Selected from Poster Abstracts
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Systemic and Local Determinants of Age-Related Lung Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"A Thermodynamics-Inspired View of Lung Aging and Regeneration"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 12:10 pm
"Alveolar Type 2 Cell Rejuvenation as a Window into Reversing Pulmonary Fibrosis and Promoting Lung Healthspan"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Linking the Rare to Repair: Identifying the Targetable Genes and Pathways that Drive Uncommon Lung Diseases
6:00 pm - 6:20 pm
"Identification of Disease Mechanisms in Alpha-1 Antitrypsin Deficiency-Associated Emphysema"
6:20 pm - 6:25 pm
Discussion
6:25 pm - 6:45 pm
"Epithelial Progenitors Predict Lung Cancer Regression"
6:45 pm - 6:50 pm
Discussion
6:50 pm - 7:05 pm
"Gene and Cell Therapies for Childhood Interstitial Lung Diseases and Bronchopulmonary Dysplasia"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Neurocrest Cells Drive TSC and LAM Tumorigenesis"
7:30 pm - 7:35 pm
Discussion
7:35 pm - 7:55 pm
"Tbx4 Mutation Drives Defective Alveolarization and PH, Driven by Aberrant Pericyte-Endothelial Interaction"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure