Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Sources of Genome Instability in Cancer
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"BRCA1/2 Functions in Homologous Recombination"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Localizing Double-Strand Breaks and Their Sources"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Telomeres and Other Genome Instability Hotspots
9:00 am - 9:20 am
"DNA Helicases in Telomere Biology and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"How Telomeres Solve the End-Replication Problem"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Phase Transition Drives Telomere Clustering"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Repairing Bursts of Double-Strand Breaks Leads to Genome-Wide Hypermutation"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"APOBEC3A Drives Hotspot Mutations at DNA Stem-Loops in Cancers"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Telomere Crisis and Genome Instability in Cancer"
11:40 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Induction and Repair of Damage in Telomeres"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
High Resolution DNA Repair
7:30 pm - 7:50 pm
"Base Excision Repair at Atomic Resolution"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Time-Resolved DNA Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Defining the Repair Outcomes Mediated by C-NHEJ Versus ALT-EJ"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Molecular Mechanism of Chromosome Maintenance by Homologous Recombination"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Replication Stress: Fork Stability and Repair
9:00 am - 9:20 am
"Regulation of Genome Stability by Replication Fork Remodeling"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Repairing and Bypassing Crosslinks"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Roles and Consequences of Fork Reversal During DNA Interstrand Crosslink Repair"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Novel Regulation of BRCA1 in Replication Fork Protection"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Replication Stress Response in BRCA1-Deficient Cells"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Keeping DNA Repair Nucleases in Check to Maintain Genome Stability"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"MRE11-RAD50-NBS1 Activates Fanconi Anemia R-Loop Suppression at Transcription-Replication Conflicts"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Targeting the DNA Damage Response"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms and Applications of Genome Editing
7:30 pm - 7:50 pm
"Mechanisms of Gene Targeting"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Fanconi Anemia Pathway Is Required for Templated DNA Repair at Double Strand Breaks"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"How the Local Chromatin Environment Influences Genome Editing with CRISPR-Cas9"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:25 pm
"Persons and Perspectives in the History of DNA Repair"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Insights into Mechanisms of Repair and Signaling
9:00 am - 9:20 am
"Double Strand Break Repair and Human Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Ubiquitin Phosphorylation as Novel Modulator of the DNA Damage Response"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Nuclear Filamentous Actin Functions in the Replication Stress Response"
11:15 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Models of Checkpoint Kinase Inactivation Reveal Unexpected Functions"
11:40 am - 11:50 am
Discussion
11:50 am - 12:10 pm
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Opportunities for Therapeutic Intervention in Cancer
7:30 pm - 7:50 pm
"New Players in DNA Repair and Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Werner Helicase Function Is Required for the Survival of Cancer Cells with Microsatellite Instability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Ewing Sarcoma: A Case Study of Clonal Aneuploidy and DNA Damage Repair in Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Role of 5-Hydroxymethyl Cytosine (5hmC) in Maintaining the Integrity of Stalled Replication Forks"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Protecting Our Genome: Whenever, Wherever"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Failures of DNA Repair and Consequences for Human Disease
9:00 am - 9:20 am
"Mining Cancer Genomes for Insights into Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"DNA Repair: From Fanconi Anemia to Huntington Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Alternative Repair of Oxidatively-Stressed Replication Forks"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"NAIF1-Constituted Nucleoskeleton Suppresses Chromosome Translocation and Tumorigenesis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Learning from Rare Inherited Diseases: A Case Study"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"A Genome-Wide Evolutionary Analysis Screen for DNA Damage Response Factors Reveals DDIAS as a Novel Homologous Recombination Gene"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Fanconi Anemia Pathway Protects Mitochondrial DNA Replication Forks to Suppress Inflammation and Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Manipulation of DNA Repair Protein by Oncogenic Virus"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Pathway Choice and Break Repair
7:30 pm - 7:50 pm
"Chromatin Dynamics and Double-Strand Break Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"NBS1 Promotes the Endonuclease of the MRE11-RAD50 Complex by Sensing CtIP Phosphorylation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"The SNM1A Nuclease Is Required for the Repair of Complex DNA Breaks"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Insights from a New CryoEM Structure of TFIIH"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Molecular Mechanisms of DNA Protein Crosslink Repair"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure