Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Connecting DNA Repair with DNA Replication
7:40 pm - 8:25 pm
"The Causes and Consequences of Replication Stress"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
"Transcription-Coupled DNA Repair in a Test Tube"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Repair of Chromosomal Breaks
9:00 am - 9:20 am
"Protecting Genome By Homologous Recombination"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"CIP2A and the Spillover of DNA Lesions in Mitosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"RAD51 Paralog Containing Complex SWSAP1-SWS1 Stimulates D-Loop Formation with Physiologically Relevant Substrate RPA Coated ssDNA"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Single-Molecule Studies Reveal a Chaperone-Like Behavior of the Rad51 Paralog Complex Rad55-Rad57"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Assembly and Disassembly of the Shieldin Complex"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Error-Prone, Stress-Induced 3’ Flap-Based Okazaki Fragment Maturation Supports Cell Survival"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"RNA Transcripts Stimulate Homologous Recombination by Forming DR-Loops"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural Basis of Double Strand DNA Break Repair in NHEJ"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Base Excision Repair
Session in memory of Sam Wilson.
7:30 pm - 7:50 pm
"Mechanisms of Base Excision Repair"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Architecture and Mechanism of BER Complexes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"UV-DDB Functions to Stimulate Multiple DNA Glycosylases During Base Excision Repair of a Wide Variety of DNA Lesions: From Single-Molecules to Cells"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Base Excision Repair of Oxidatively Damaged G-Quadruplex DNA"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Replication and Replication Stress Response
9:00 am - 9:20 am
"Mechanisms of Replication-Coupled DNA Repair"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Progress Towards Determining the Structural Basis For Function of RADX"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"RFWD3 in the Replication Stress Response"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Single-Molecule Investigation of DNA-Binding Proteins in Real Time"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"How Cell Cycle Checkpoints Regulate DNA Damage Driven Inflammatory Signals"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Mechanisms of Replication Stress Response to Chemotherapeutics"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Poly-ADP-Ribosylation Modifies DNA-Protein Crosslinks to Signal For SPRTN-Dependent Degradation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Investigating the Mechanisms Behind R-Loop Induced Lethality upon Replication-Transcription Conflicts"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Repair and Human Diseases
7:30 pm - 7:50 pm
"The Role of the Fanconi Anemia Pathway in Resolving Endogenous DNA Damage"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Repairing Retrotransposition"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"APOBEC Mutagenesis in Mice and Humans"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Regulation of APOBEC3A Mutagenesis and Inflammation by the DNA Damage Response"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Transcription Reprogramming and Fanconi Anemia"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Genetics and Genomics of DNA Repair
9:00 am - 9:20 am
"Expression Catalytic Inactive PARP1 in Mouse Is More Toxic than Loss of Both PARP1 and PARP2"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"DNA Base Damage and Repair Interplay with Chromatin Structures to Modulate Trinucleotide Repeat Instability"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Genetic Interaction Between Brca1 and Fancm in Stalled Fork Repair"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"BRCA2 Associates with MCM10 to Suppress PrimPol-Mediated Re-Priming and Single-Stranded DNA Gap Formation After DNA Damage"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Targeting DNA Repair Vulnerabilities in Cancer"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"PIF1 Helicase Plays an Important Role in Break-Induced Replication in Mammalian Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"RAD21 Promotes Repair of Oncogenic Replication Stress-Induced Damage in Ewing Sarcoma "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Genomic Features of Short Sequence Insertions and Large Sequence Duplications Suggest a Common Origin from Replication of Broken DNA"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Opportunities for Therapeutic Intervention in Cancer
7:30 pm - 7:50 pm
"The Role of Transcription-Coupled Homologous Recombination (TC-HR) in Tumor Growth and Drug Resistance"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Targeting DNA Damage Repair Pathways In Cancer Therapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Genome-Wide CRISPR Screen Reveals Therapeutic Vulnerabilities in Cisplatin Resistant Bladder Cancer"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Synthetic Lethal Screen Identifies Novel Players in DNA Damage Response that Confer Etoposide-Hypersensitivity in Small Cell Lung Cancer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"FANCD2 Protects the Mitochondrial Genome from Oxidative DNA Damage"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Dissecting the Interplay Between Human DNA Damage Tolerance Pathways"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Repair and Therapeutic Responses
9:00 am - 9:20 am
"Mechanism by Which Mismatch Repair Deficiency Benefits Immunotherapy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Functional Interrogation of DNA Damage Response Variants with Base Editing Screens"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Chromatin Association Dynamics of DDR Factors Revealed by Live-Cell Single-Molecule Imaging"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Talazoparib-Focused Functional Genomic Approach Toward Novel Sensitizing Targets in BRCA-Proficient Tumors"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of DSB Repair Choice by a New Nuclease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Targeting ATM Deficiency in Cancer Therapy"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Temporal Dynamics of Base Excision/Single-Strand Break Repair Protein Complex Assembly and Disassembly Are Modulated by the PARP1/PARP2/NAD+/SIRT6 Axis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"PARP1 and PARP2 Prevent Oxidative Stress-Mediated Telomere Crisis Through Distinct Pathways"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Telomeres Maintenance and Genomic Instability
7:30 pm - 7:50 pm
"A Telomere-Mitochondria Axis Regulates Inflammation in Replicative Crisis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Nuclear Sensing of Mitochondrial DNA Breaks Enhances Immune Surveillance"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Crosstalk Between CST, RPA, RAD51 and BRCA2 at Stalled Forks"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Telomeric 8-Oxoguanine Drives Premature Senescence Independently of Telomere Shortening "
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Critical Roles of a Lysine Methylation in the C-Terminal SAP Domain of KU70 in Its Functions"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure