Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Mechanisms of Chromosome Instability
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Mutational Processes Driving Rapid Genome Evolution"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Protecting the Genome by Homologous Recombination"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chromosomal Breaks: Mechanisms and Repair
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Targeting MMEJ for the Treatment of HR-Deficient Cancers"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"KU Unleashed: Adaptation and Exaptation from Non-Homologous End-Joining and Beyond"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Unraveling A-EJ and DDR Mechanisms Through V(D)J Recombination"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"BRCA1-A complex restricts chromatin remodeling dependent replication fork resection in ATM-deficient cells"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Mechanism of End Joining Pathways for Double Strand Break Repair"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Regulation of MRE11 with Implications on Genome Stability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"CIP2A is Required to Recruit the SMX Complex to Mitotic Replication Stress Lesions"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Guardians of Mitosis: CIP2A-TOPBP1 Driven Mitotic Regulation of MiDAS and MMEJ"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biochemical Reconstitution of DNA Repair
7:30 pm - 7:50 pm
"Multifaceted Role of BRCA1-BARD1 in Homologous Recombination Licensing"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Understanding the Mechanism of Trinucleotide Repeat Expansion Through Biochemical Reconstruction"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Structural and Molecular Basis of PCNA-Activated FAN1 Nuclease Function in DNA Repair"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"PCNA Encircling Primer/Template Junctions Is Eliminated by Exchange of RPA for Rad51: Implications for the Interplay Between Human DNA Damage Tolerance Pathways"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"A Tale of Two RAD51 Paralog Complexes"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Repair in Telomeres and Repetitive Sequences
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Base Excision Repair of Oxidative Damage at Telomeres"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Regulation of transcription-dependent homologous recombination repair"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Lessons from a Combinatorial CRISPR Screen: From Telomere Protection to the Response to Irradiation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:30 am
"RNA Transcripts Serve as a Template for Double-Strand Break Repair in Human Cells"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"CHAMP1 Complex Directs Heterochromatin Assembly and Promotes Homology-Directed DNA Repair"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Maintaining Balance: Safeguarding the Centromeric DNA Integrity and Function"
11:35 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"Chromosome and Chromatin Dynamics at DNA Double Strand Breaks"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Evolution of Cells Progressing Through Replicative Crisis to Immortality"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Excision Repair and Genome Integrity
7:30 pm - 7:50 pm
"Exploiting Endogenous Base Damage to Enhance Therapeutic Utility of PARP Inhibitors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"ADP-Ribosylation Signalling in Regulation of Genome Stability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Deciphering the Mechanisms of Transcription Factor-Mediated DNA Damage Formation and Repair"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Function of DNA Repair Machineries in Circular DNA Biogenesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular Basis for the Stimulation of a DNA Repair Nuclease by CSB"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
DNA Damage and Disease: Etiology and Therapeutics and Disease
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"BRCA Structure and Function in Disease and Inflammation: A Tale of Two Genome Instabilities"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Regulation of the Fanconi Anemia DNA Repair Pathway"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Acute BRCAness Induction and PARP Inhibition in Prostate Cancer"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"The DNA Damage Response Pathway is Required for Multiciliated Cell Differentiation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Charting DNA Damage and DNA Repair Pathways"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Beyond BRCA: An Explanation for the PARP Inhibitor Response of ATM-Deficient Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mechanism of Fork Breakage During Replication Catastrophe"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Homologous Recombination Promotes Non-Immunogenic Mitotic Cell Death Upon DNA Damage"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Damage, Repair and Immune Signaling
7:30 pm - 7:50 pm
"The Interplay Between the DNA Damage Response Pathway and the Innate Immune System in Mitosis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Micronuclear Proteomes are a Window to Mechanisms of Genomic Instability"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Causes and Consequences of Replication Stress"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Mechanisms of Chromothripsis from Mitotic Errors and Micronuclei"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Chromatin Determinants of Replication and Repair
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Homology Search in 3D Genome"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Hijacking Centromeric Factors to Limit Mitotic DNA Synthesis at ALT Telomeres"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Multigenerational Single Cell Tracking to Study Principles of DNA Damage Inheritance"
10:25 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Epigenetic Mechanisms for Heterochromatin Repair"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Dissecting the Role for Heterochromatin and Inter-Chromosomal Interactions in Short Tandem Repeat Instability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Epigenetic Landscape Modulates Smoking-Induced DNA Damage Formation, DNA Repair and Mutagenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Methylglyoxal-Induced DNA Damage and Mutagenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
DNA Replication Coupled Repair
7:30 pm - 7:50 pm
"Regulation of DNA Replication Stress by Nucleases"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Mechanism of Cell-Free Transcription-Coupled Nucleotide Excision Repair"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Mechanisms of Break Induced Replication"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Mechanism for Local Attenuation of DNA Replication at Double-Strand Breaks"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Regulation of Error-Free and Error-Prone Repair at Stalled Mammalian Replication Forks"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure