Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Niches in Development and Disease
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:10 pm
Introduction by Discussion Leader
8:10 pm - 9:10 pm
"Hypoxia, Stem Cells, and Survival"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Identity, Regulation and Therapeutic Targeting of
Stem Cells
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Stem Cell Signals in Cancer Heterogeneity and Therapy Resistance"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Targeting Sleeping Cancer Cells"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"3-D Simulations of Multicellular Systems Biology in Ductal Carcinoma In Situ "
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Identification and Targeting Stem Cell Regulatory
Pathways"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Mammary 'ECM' and Induction of Mammary Development by Non-Mammary Cells: Significance to Multipotent vs Unipotent Mammary Progenitor/Stem Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stromal Determinants of Epithelial Cell Behavior
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Stromal Determinants of Epithelial Cell Behavior
7:40 pm - 8:05 pm
"Regulation of Mammary Gland Development and Tumorigenesis by Macrophage-Directed Epithelial"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Matrix Stiffness and Tumor Development"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Ionizing Radiation Promotes Aggressive Tumors that Exhibit Increased Immune Suppression"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Primary Breast Tumor Stiffness Instructs Osteotropic Metastasis via Mechanical Memory"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Heterogeneity in Development and Disease
9:00 am - 9:15 am
Introduction by Discussion Leader: Heterogeneity in Development and Disease
9:15 am - 9:40 am
"Tracking Functional Heterogeneity and Intratumoral Crosstalk of Triple Negative Breast Cancer Cells"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Breast Cancer Heterogeneity, Axial Patterning, and
the Mammary Microenvironment"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Clonal Cooperativity in Tumor Development"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Investigation of Intratumor Heterogeneity in Cancer Progression and Metastasis at the Single-Cell Level"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Regenerable Altruism Drives Chemotolerance in Clonal Cancer Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mammary Epithelial Cell Plasticity
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Mammary Epithelial Cell Plasticity
7:40 pm - 8:05 pm
"Molecular Regulation of Tumor-Initiating Cell
Plasticity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Breast Cancer Risk Prediction and Prevention"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Epigenetic Mechanisms of Primary Human Mammary Epithelial Cell Dedifferentiation"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"BRCA1-Loss Triggers Alteration in the Fates of ER+ and ER- Mammary Luminal Cells"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader: Lactation Biology
9:15 am - 9:40 am
"Lessons About Mammary Development and Lactation from Diverse Inbred Mouse Strains"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"The Multifarious Lactation Strategies of Mammals"
10:20 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Metabolic Adaptation in Lactation: A Model for Breast Cancer Progression?"
11:30 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"Cell Biology of Lactation: Docking and Stimulated Secretion of Milk Fat Globules"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Errors in Developmental Programming Increase Susceptibility to Metastasis"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion: Lactation Biology
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cellular Dormancy in Development, Treatment
Resistance, and Recurrence
7:30 pm - 7:40 pm
Introduction by Discussion Leader: Cellular Dormancy in Development, Treatment Resistance, and Recurrence
7:40 pm - 8:05 pm
"Tumor Dormancy as a Window to Prevent Metastatic Recurrence"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Cell Polarity Proteins and Cell Surface Proteome –
Impact on Mammary Gland Development and Cancer"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Metabolic Shifts in Residual Breast Cancer Drive Tumor Recurrence"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Tracking and Targeting Aggressive Clones in Metastatic Triple Negative Breast Cancer"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Unconventional Mechanisms Controlling Organogenesis
and Carcinogenesis
9:00 am - 9:15 am
Introduction by Discussion Leader: Unconventional Mechanisms Controlling Organogenesis and Carcinogenesis
9:15 am - 9:40 am
"Paracrine Signaling in Development and Disease"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Dominance of Mitochondria over the Malignant Phenotype"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Long Non-Coding RNAs as Targets in Mammary Cancer Progression"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Neutrophil Extracellular Traps Promote Breast Cancer Metastasis and Escape from Dormancy"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Unraveling the Mechanisms Behind Species-Resistance to Mammary Cancer"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Mammary Gland Research
7:30 pm - 7:45 pm
Introduction by Discussion Leader: Future Directions in Mammary Gland Research
7:45 pm - 8:45 pm
"Mammary Development, Cancer, and Epithelial Homeostasis"
8:45 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure