Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Establishing Complex Tissue Architecture by Integrating Mechanical and Biochemical Cues
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:05 pm
Introduction by Discussion Leader
8:05 pm - 9:05 pm
"Establishing Complex Tissue Architecture by Integrating Mechanical and Biochemical Cues"
9:05 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Transcriptional and Translational Control of Mammary Gland Development and Breast Cancer
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Molecular Programs of Epithelial Motility During Branching Morphogenesis and Cancer Invasion"
9:35 am - 9:50 am
Discussion
9:50 am - 10:15 am
"The Effects of Pregnancy on Gene Regulation, Development and Cancer"
10:15 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Linking Arginine Methylation with the Epigenetic Regulation of Breast Cancer Stem Cells: New Therapeutic Opportunities?"
11:20 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Proliferative Heterogeneity of Mammary Epithelial Cells"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Emerging Aspects of Metastasis
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"Targeting Vulnerabilities of Circulating Tumor Cell Clusters"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Immunotherapy in Breast Cancer, Current Clinical Data and New Perspectives"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Defining How Cooperative Interactions Between Tumor Subpopulations Promote Metastasis"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mammary Gland Biology Beyond Mice and Women
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"From Networks to Function – Computational Models of Organogenesis"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Biomarkers of Breast Cancer Risk in Breastmilk: Inflammation, Methylation and Mutations"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Identifying Tumourigenesis Pathways and Anti-Cancer Compounds Relevant to Human Breast Cancer Using the Drosophila Model Organism"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Targeting Sorting Nexins to Treat ERBB-Dependent Breast Cancer"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Powerhouse of the Breast Cancer Cell: How Regulation of dAKAP1 Expression Influences Cell Motility via Changes in Mitochondrial Dynamics"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Breast Cancer Heterogeneity and Precision Medicine
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"Delineating Normal Breast Biology and Cancer with Single Cell Genomics"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Mechanisms of Early Dissemination and Metastasis Formation"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"Single Cell Atlas of Tumor and Immune Cell Heterogeneity in Human Breast Cancer"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Physiological and Environmental Factors that Influence Lactation and Breast Cancer Risk
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Mechanobiology of Epithelial Growth and Folding"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"ER Rewired: Receptor Signaling in Therapy Resistant and Invasive Lobular Breast Cancer"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Causes of Dysfunction in the Lactating Mammary Gland"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Cytokeratin 5/Beta-Catenin Interaction and Crosstalk in Maintaining Breast Cancer Stem Cells"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Genomic Alterations Impact Metastatic Potential and Oncogenic Signaling of Mouse Models of Breast Cancer"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
(Immune) System Interactions in Development and Disease
6:00 pm - 6:15 pm
Introduction by Discussion Leader
6:15 pm - 6:40 pm
"Breast Cancer Highjacks a Developmental Program of Immune Suppression: Hormonal and Inflammatory Mediators"
6:40 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Targeting Pro-Survival Signaling – Exposing an Achilles’ Heel in Breast Cancer?"
7:20 pm - 7:35 pm
Discussion
7:35 pm - 7:50 pm
"A Novel Eya3/Myc/PD-L1 Axis Drives TNBC Progression via Regulation of CD8+ T-Cell Exhaustion"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Developmental Signaling and Tumor Resistance Mechanisms
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:40 am
"Exploring Cooperation of microRNAs and codingRNAs in Branching Breast Morphogenesis and EMT"
9:40 am - 9:55 am
Discussion
9:55 am - 10:20 am
"Resolving Stem Cell State Changes in the Developing Mouse Mammary Gland"
10:20 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mechanosensing and Endosomal Traffic in Mammary Gland Development and Cancer"
11:25 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Clonal Analysis of Notch1-Expressing Cells Reveals the Existence of Unipotent Stem Cells that Retain Long-Term Plasticity in the Embryonic Mammary Gland"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Mammary Myoepithelial Cells Respond to Damage by Altering Cell Fate In Vivo "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Fate, Potential and Lineage Commitment of Mammary Gland Stem Cells
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 7:10 pm
"Fate, Potential and Lineage Commitment of Mammary Gland Stem Cells"
7:10 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
General Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure