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Mammary Gland Biology

Gordon Research Conference

Mechanisms of Normal Mammary Development Inform Strategies for Prevention, Detection and Treatment of Breast Cancer

June 8 - 13, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chairs

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Vice Chairs

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Jordan Hotel at Sunday River

27 Grand Circle

Newry, Maine, United States

Venue and Travel Information

Application Information

The application deadline for this meeting was May 11, 2025. You may still submit an application, which may be considered by the conference chair if there is still room available.

Conference Description

The Mammary Gland Biology GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes an array of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Mammary Gland Biology" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: ECM in Mammary Development and Cancer Discussion Leader:
7:40 pm - 8:00 pm	Introduction by Discussion Leader
8:00 pm - 9:00 pm	"Forcing Tumor Initiation and Progression"
9:00 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Coordinating Development of the Mammary Gland Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Search for the Earliest Precursors of Human Breast Tumors"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Mitochondrial Regulation of Mammary Epithelial Cell Differentiation"
10:00 am - 10:10 am	Discussion
10:10 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Fibroblast Dynamics During Postnatal Mammary Gland Development"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Loss of Cyclin-Like Proteins Impacts Mammary Morphogenesis and Introduces New Therapeutic Vulnerabilities for Breast Cancer"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Sympathetic Nerves Modulate Mammary Gland Differentiation via Stromal Progenitors"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"The Metabolic Regulator Sirt4 is Required for Pubertal Mammary Gland Development, Potentially via its Influence on Extracellular Matrix Architecture"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	Poster Previews
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lactation and Making Milk Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Mammary Gland Ultrasound as a Method for Tracking Parenchymal Tissue Growth and Milk Production"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Dietary AGEs Impact Mammary Gland Development and Breast Cancer Risk"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"Obesity, Rather than Gestational Diabetes, Impairs Breastmilk Production During Early Lactation"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"In-Vivo Cellular and Microbial Atlas of the Lactating Nipple: Advancing Non-Invasive Diagnostics for Chronic Lactational Nipple Pain"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"Milk Excretion and Myoepithelial Cell Contractility: Modulation by the Na+-Activated K+ Channels, SLO2.1"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Methods in Normal and Cancer Development Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Uncovering New Roles for Calcium Signaling in Lactation"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Balancing Order and Disorder during the Self-Organization of the Mammary Gland"
10:00 am - 10:10 am	Discussion
10:10 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Quantitative Lineage Tracing Reveals Cellular and Physical Rules of Tumor Progression"
11:05 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Decoding the Impact of Pregnancy on Aging of Mammary Epithelial Cells"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Diversity in Research: Current Limitations Addressing Breast Cancer Detection and Treatment"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Exploring the Link Between the DNA Damage Response Functionality of KAP1 and Its Impact on Mammary Epithelial Cell Differentiation"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:15 pm	Poster Previews
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Transcriptional Regulation of Development and Cancer Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Hormonal Control of Gene Expression: Implications for Breast Cancer Risk"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Myeloid-Derived Suppressor Cells Enable the Premetastatic Niche Formation in Triple-Negative Breast Cancer"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:45 pm	"NF1 Deficiency Promotes Breast Cancer and Endocrine Resistance in NF Related Breast Cancer by Altered ER Signaling and Chromatin Remodeling"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"Apobec3 Dysregulation Drives Complex Chromosomal Rearrangements and ecDNA Formation in HER2/Neu Positive Mammary Tumors"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Prevention, Therapy and Metastasis/Dormancy Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Discovery of Epigenomic Factors Driving HER2-Positive Ductal Carcinoma in Situ (DCIS) to Enable Precision Prevention and Targeted Therapy"
9:30 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Mitochondria at the Crossroads of Bioenergetics and Stress Signaling in Therapy Resistant Triple Negative Breast Cancer"
10:00 am - 10:10 am	Discussion
10:10 am - 10:30 am	"Dormant Disseminated Breast Cancer Cells: Origins, Biology and Clinical Implications"
10:30 am - 10:40 am	Discussion
10:40 am - 11:10 am	Group Photo / Coffee Break
11:10 am - 11:20 am	"PDGFB as a Pro-Tumorigenic Driver in Breast Epithelium"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	"Endothelial Cell Autophagy Plays Context Specific Functions in PyMT Tumor Progression"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Molecular Impacts of Differential Gene Expression of IRF5 and CAPN9 in Estrogen Receptor(+) Breast Cancer"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Right Place, Wrong Time: Triple-Negative Breast Cancer Invasion Repurposes Hybrid E/M Gene Signature from Pubertal Development"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Role of Non-Tumor Cells in Breast Cancer Progression and Mammary Development Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Aging, the Immune System and Breast Cancer"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Macrophage Heterogeneity in Mammary Gland Development and Breast Cancer Progression"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"The Role of the Tumor Microenvironment in Driving Breast Cancer Progression"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"Investigating the Metabolic Crosstalk Between PIK3CA-H1047R-Mutated Mammary Epithelial Cells and M2 Macrophages in Promoting Age-Related Breast Cancer"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Impact of Mammary Research on Clinical Decision Making Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Tumor Microenvironmental Determinants of High-Risk DCIS Progression"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Insights into TNBC"
10:05 am - 10:15 am	Discussion
10:15 am - 10:40 am	Coffee Break
10:40 am - 11:00 am	"Precision Medicine Trials Using PDX and Organoids"
11:00 am - 11:10 am	Discussion
11:10 am - 11:20 am	"Eco-Evolutionary Guided Pathomic Analysis to Predict Ductal Carcinoma In Situ Upstaging"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	"Modeling Human Mammary Epithelial Lineages Using Patient-Derived Organoid Cultures"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"The Physician/Patient Perspective"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Funding Opportunities in Breast Cancer from ACS"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:20 pm	"Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy and Targeted Agent Responses"
12:20 pm - 12:25 pm	Discussion
12:25 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Breast Cancer Discussion Leader:
7:30 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:35 pm	"Advancing Breast Cancer Research: Next-Generation Mouse and Rat Models"
8:35 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	General Discussion
9:15 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Mammary Gland Biology (GRS) Contribute Financially to This Conference

Conference Fees

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$1,665.00

Conferee Shared Room:

$1,300.00

Conferee Off-Site:

$930.00

Guest Single Room:

$1,475.00

Guest Shared Room:

$1,110.00

Guest Off-Site:

$740.00

Child 4-12 yrs Shared Room:

$555.00

Child 4-12 yrs Off-Site:

$370.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$62.00

Bus Departing:

$62.00

Additional Fee Info

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May 30 - 31, 2026

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