Sunday 
 
 
2:00 pm - 9:00 pm 
	
Arrival and Check-in
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 7:40 pm 
	
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
 
 
						 
						 
					
						
						
7:40 pm - 9:30 pm 
	
Keynote Session: ECM in Mammary Development and Cancer 
 
 
 
						 
						 
					
						
						
7:40 pm - 8:00 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
8:00 pm - 9:00 pm 
	
"Forcing Tumor Initiation and Progression" 
 
 
 
						 
						 
					
						
						
9:00 pm - 9:30 pm 
	
Discussion
 
 
						 
						 
					
						
						
	Monday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Coordinating Development of the Mammary Gland 
 
 
 
						 
						 
					
						
						
9:00 am - 9:10 am 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
9:10 am - 9:30 am 
	
"Search for the Earliest Precursors of Human Breast Tumors" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:40 am 
	
Discussion
 
 
						 
						 
					
						
						
9:40 am - 10:00 am 
	
"Developmental Origins of Mammographic Density and Breast Cancer Risk" 
 
 
 
						 
						 
					
						
						
10:00 am - 10:10 am 
	
Discussion
 
 
						 
						 
					
						
						
10:10 am - 10:45 am 
	
Coffee Break
 
 
						 
						 
					
						
						
10:45 am - 11:05 am 
	
"Fibroblast Dynamics During Postnatal Mammary Gland Development" 
 
 
 
						 
						 
					
						
						
11:05 am - 11:15 am 
	
Discussion
 
 
						 
						 
					
						
						
11:15 am - 11:25 am 
	
"Loss of Cyclin-Like Proteins Impacts Mammary Morphogenesis and Introduces New Therapeutic Vulnerabilities for Breast Cancer" 
 
 
 
						 
						 
					
						
						
11:25 am - 11:30 am 
	
Discussion
 
 
						 
						 
					
						
						
11:30 am - 11:40 am 
	
"Sympathetic Nerves Modulate Mammary Gland Differentiation via Stromal Progenitors" 
 
 
 
						 
						 
					
						
						
11:40 am - 11:45 am 
	
Discussion
 
 
						 
						 
					
						
						
11:45 am - 11:55 am 
	
"The Metabolic Regulator Sirt4 is Required for Pubertal Mammary Gland Development, Potentially via its Influence on Extracellular Matrix Architecture" 
 
 
 
						 
						 
					
						
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:00 pm - 12:15 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:15 pm - 12:30 pm 
	
General Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Lactation and Making Milk 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
7:35 pm - 7:55 pm 
	
"Mammary Gland Ultrasound as a Method for Tracking Parenchymal Tissue Growth and Milk Production" 
 
 
 
						 
						 
					
						
						
7:55 pm - 8:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:05 pm - 8:25 pm 
	
"Dietary AGEs Impact Mammary Gland Development and Breast Cancer Risk" 
 
 
 
						 
						 
					
						
						
8:25 pm - 8:35 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:35 pm - 8:45 pm 
	
"Human Milk-Derived Cells Reveal Exercise-Induced Lipokines That Enhance Infant Thermogenesis" 
 
 
 
						 
						 
					
						
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:00 pm 
	
"In-Vivo Cellular and Microbial Atlas of the Lactating Nipple: Advancing Non-Invasive Diagnostics for Chronic Lactational Nipple Pain" 
 
 
 
						 
						 
					
						
						
9:00 pm - 9:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:05 pm - 9:15 pm 
	
"Myoepithelial Cell Excitability and Contractility: Modulation by the Na+-Activated K+ Channels, SLO2.1" 
 
 
 
						 
						 
					
						
						
9:15 pm - 9:20 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
General Discussion
 
 
						 
						 
					
						
						
	Tuesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Methods in Normal and Cancer Development 
 
 
 
						 
						 
					
						
						
9:00 am - 9:10 am 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
9:10 am - 9:30 am 
	
"Balancing Order and Disorder during the Self-Organization of the Mammary Gland" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:40 am 
	
Discussion
 
 
						 
						 
					
						
						
9:40 am - 10:00 am 
	
"Decoding the Impact of Pregnancy on Aging of Mammary Epithelial Cells" 
 
 
 
						 
						 
					
						
						
10:00 am - 10:10 am 
	
Discussion
 
 
						 
						 
					
						
						
10:10 am - 10:45 am 
	
Coffee Break
 
 
						 
						 
					
						
						
10:45 am - 11:05 am 
	
"Quantitative Lineage Tracing Reveals Cellular and Physical Rules of Tumor Progression" 
 
 
 
						 
						 
					
						
						
11:05 am - 11:15 am 
	
Discussion
 
 
						 
						 
					
						
						
11:15 am - 11:25 am 
	
"Exploring the Molecular Features of Breast Cancer Diagnosed During Pregnancy" 
 
 
 
						 
						 
					
						
						
11:25 am - 11:30 am 
	
Discussion
 
 
						 
						 
					
						
						
11:30 am - 11:40 am 
	
"Diversity in Research: Current Limitations Addressing Breast Cancer Detection and Treatment" 
 
 
 
						 
						 
					
						
						
11:40 am - 11:45 am 
	
Discussion
 
 
						 
						 
					
						
						
11:45 am - 11:55 am 
	
"Exploring the Link Between the DNA Damage Response Functionality of KAP1 and Its Impact on Mammary Epithelial Cell Differentiation" 
 
 
 
						 
						 
					
						
						
11:55 am - 12:00 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:00 pm - 12:15 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:15 pm - 12:30 pm 
	
General Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Transcriptional Regulation of Development and Cancer 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
7:35 pm - 7:55 pm 
	
"Hormonal Control of Gene Expression: Implications for Breast Cancer Risk" 
 
 
 
						 
						 
					
						
						
7:55 pm - 8:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:05 pm - 8:25 pm 
	
"Myeloid-Derived Suppressor Cells Enable the Premetastatic Niche Formation in Triple-Negative Breast Cancer" 
 
 
 
						 
						 
					
						
						
8:25 pm - 8:35 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:35 pm - 8:45 pm 
	
"NF1 Deficiency Promotes Breast Cancer and Endocrine Resistance in NF Related Breast Cancer by Altered ER Signaling and Chromatin Remodeling" 
 
 
 
						 
						 
					
						
						
8:45 pm - 8:50 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:50 pm - 9:00 pm 
	
"Apobec3 Dysregulation Drives Complex Chromosomal Rearrangements and ecDNA Formation in HER2/Neu Positive Mammary Tumors" 
 
 
 
						 
						 
					
						
						
9:00 pm - 9:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:05 pm - 9:15 pm 
	
"Characterizing Intercellular Adhesion Desmosome Proteins Highly Expressed in Triple-Negative Breast Cancers" 
 
 
 
						 
						 
					
						
						
9:15 pm - 9:20 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
General Discussion
 
 
						 
						 
					
						
						
	Wednesday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Prevention, Therapy and Metastasis/Dormancy 
 
 
 
						 
						 
					
						
						
9:00 am - 9:10 am 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
9:10 am - 9:30 am 
	
"Discovery of Epigenomic Factors Driving HER2-Positive Ductal Carcinoma in Situ (DCIS) to Enable Precision Prevention and Targeted Therapy" 
 
 
 
						 
						 
					
						
						
9:30 am - 9:40 am 
	
Discussion
 
 
						 
						 
					
						
						
9:40 am - 10:00 am 
	
"Mitochondria at the Crossroads of Bioenergetics and Stress Signaling in Therapy Resistant Triple Negative Breast Cancer" 
 
 
 
						 
						 
					
						
						
10:00 am - 10:10 am 
	
Discussion
 
 
						 
						 
					
						
						
10:10 am - 10:30 am 
	
"Dormant Disseminated Breast Cancer Cells: Origins, Biology and Clinical Implications" 
 
 
 
						 
						 
					
						
						
10:30 am - 10:40 am 
	
Discussion
 
 
						 
						 
					
						
						
10:40 am - 11:10 am 
	
Group Photo / Coffee Break
 
 
						 
						 
					
						
						
11:10 am - 11:20 am 
	
"PDGFB as a Pro-Tumorigenic Driver in Breast Epithelium" 
 
 
 
						 
						 
					
						
						
11:20 am - 11:25 am 
	
Discussion
 
 
						 
						 
					
						
						
11:25 am - 11:35 am 
	
"Endothelial Cell Autophagy Plays Context Specific Functions in PyMT Tumor Progression" 
 
 
 
						 
						 
					
						
						
11:35 am - 11:40 am 
	
Discussion
 
 
						 
						 
					
						
						
11:40 am - 11:50 am 
	
"Molecular Impacts of Differential Gene Expression of IRF5 and CAPN9 in Estrogen Receptor(+) Breast Cancer" 
 
 
 
						 
						 
					
						
						
11:50 am - 11:55 am 
	
Discussion
 
 
						 
						 
					
						
						
11:55 am - 12:05 pm 
	
"Right Place, Wrong Time: Triple-Negative Breast Cancer Invasion Repurposes Hybrid E/M Gene Signature from Pubertal Development" 
 
 
 
						 
						 
					
						
						
12:05 pm - 12:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:10 pm - 12:30 pm 
	
Poster Previews
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Role of Non-Tumor Cells in Breast Cancer Progression and Mammary Development 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:35 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
7:35 pm - 7:55 pm 
	
"Multifaceted Role of Chil3L1 in the Modulation of Tumour Immune Microenvironment" 
 
 
 
						 
						 
					
						
						
7:55 pm - 8:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:05 pm - 8:25 pm 
	
"Macrophage Heterogeneity in Mammary Gland Development and Breast Cancer Progression" 
 
 
 
						 
						 
					
						
						
8:25 pm - 8:35 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:35 pm - 8:55 pm 
	
"The Role of the Tumor Microenvironment in Driving Breast Cancer Progression" 
 
 
 
						 
						 
					
						
						
8:55 pm - 9:05 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:05 pm - 9:15 pm 
	
"Control of Immunosuppressive Hubs in Spatially Heterogeneous TNBC" 
 
 
 
						 
						 
					
						
						
9:15 pm - 9:20 pm 
	
Discussion
 
 
						 
						 
					
						
						
9:20 pm - 9:30 pm 
	
General Discussion
 
 
						 
						 
					
						
						
	Thursday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
8:30 am - 9:00 am 
	
Business Meeting 
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s) 
 
 
						 
						 
					
						
						
9:00 am - 12:30 pm 
	
Impact of Mammary Research on Clinical Decision Making 
 
 
 
						 
						 
					
						
						
9:00 am - 9:15 am 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
9:15 am - 9:35 am 
	
"Tumor Microenvironmental Determinants of High-Risk DCIS Progression" 
 
 
 
						 
						 
					
						
						
9:35 am - 9:45 am 
	
Discussion
 
 
						 
						 
					
						
						
9:45 am - 10:05 am 
	
"What We Understand About the Rising Incidence of Young Onset Breast Cancer" 
 
 
 
						 
						 
					
						
						
10:05 am - 10:15 am 
	
Discussion
 
 
						 
						 
					
						
						
10:15 am - 10:40 am 
	
Coffee Break
 
 
						 
						 
					
						
						
10:40 am - 11:00 am 
	
"Precision Medicine Trials Using PDX and Organoids" 
 
 
 
						 
						 
					
						
						
11:00 am - 11:10 am 
	
Discussion
 
 
						 
						 
					
						
						
11:10 am - 11:20 am 
	
"Eco-Evolutionary Guided Pathomic Analysis to Predict Ductal Carcinoma In Situ Upstaging" 
 
 
 
						 
						 
					
						
						
11:20 am - 11:25 am 
	
Discussion
 
 
						 
						 
					
						
						
11:25 am - 11:35 am 
	
"Modeling Human Mammary Epithelial Lineages Using Patient-Derived Organoid Cultures" 
 
 
 
						 
						 
					
						
						
11:35 am - 11:40 am 
	
Discussion
 
 
						 
						 
					
						
						
11:40 am - 11:50 am 
	
"The Physician/Patient Perspective" 
 
 
 
						 
						 
					
						
						
11:50 am - 11:55 am 
	
Discussion
 
 
						 
						 
					
						
						
11:55 am - 12:05 pm 
	
"Funding Opportunities in Breast Cancer from ACS" 
 
 
 
						 
						 
					
						
						
12:05 pm - 12:10 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:10 pm - 12:20 pm 
	
"Patient-Derived Xenografts of Triple-Negative Breast Cancer Enable Deconvolution and Prediction of Chemotherapy and Targeted Agent Responses" 
 
 
 
						 
						 
					
						
						
12:20 pm - 12:25 pm 
	
Discussion
 
 
						 
						 
					
						
						
12:25 pm - 12:30 pm 
	
General Discussion
 
 
						 
						 
					
						
						
12:30 pm - 1:30 pm 
	
Lunch
 
 
						 
						 
					
						
						
1:30 pm - 4:00 pm 
	
Free Time
 
 
						 
						 
					
						
						
4:00 pm - 6:00 pm 
	
Poster Session 
 
 
						 
						 
					
						
						
6:00 pm - 7:00 pm 
	
Dinner
 
 
						 
						 
					
						
						
7:30 pm - 9:30 pm 
	
Keynote Session: Breast Cancer 
 
 
 
						 
						 
					
						
						
7:30 pm - 7:50 pm 
	
Introduction by Discussion Leader
 
 
						 
						 
					
						
						
7:50 pm - 8:35 pm 
	
"Advancing Breast Cancer Research: Next-Generation Mouse and Rat Models" 
 
 
 
						 
						 
					
						
						
8:35 pm - 8:55 pm 
	
Discussion
 
 
						 
						 
					
						
						
8:55 pm - 9:15 pm 
	
General Discussion
 
 
						 
						 
					
						
						
9:15 pm - 9:30 pm 
	
Closing Remarks
 
 
						 
						 
					
						
						
	Friday 
 
 
7:30 am - 8:30 am 
	
Breakfast
 
 
						 
						 
					
						
						
9:00 am 
	
Departure