| SUNDAY, February 27 |
Afternoon |
| 2:00-6:00 pm |
Registration and Check-In |
| 6:00-7:00 pm |
Dinner |
| 7:00-9:00 pm |
Registration and Check-In |
| SUNDAY, February 27 |
Evening Session 7:30-9:30 pm |
| 7:30-7:40 |
Welcome and Conference Policies
Valerie Paul |
| Marine Toxins and Cytotoxic Natural Products |
| Discussion Leaders: Alison Butler and Chris Ireland |
| 7:40-8:20 |
"Challenges to the minuteness of marine toxins"
Takeshi Yasumoto |
| 8:20-8:30 |
Discussion |
| 8:30-8:50 |
"Unsuspected biological activities of marine pyridoacridines"
Louis Barrows |
| 8:50-9:00 |
Discussion |
| 9:00-9:20 |
"Recent developments in using molecular approaches to discover sponge-derived anticancer leads"
Phil Crews |
| 9:20-9:30 |
Discussion |
| 9:30-11:30 |
Chair's Welcoming Reception |
| MONDAY, February 28 |
Morning Session 9:00 am-12:30 pm |
| Marine Toxins |
| Discussion Leaders: John Cardellina and Tawnya McKee |
| 9:00-9:45 |
"Generating molecular diversity in Conus peptides: evolutionary, physiological and pharmacological strategies"
Baldomero Olivera |
| 9:45-9:55 |
Discussion |
| 9:55-10:15 |
"NMR and molecular modeling studies on the psi?conotoxins: non?competitive antagonists of the nicotinic acetylcholine receptor"
Ryan Van Wagoner |
| 10:15-10:20 |
Discussion |
| 10:20-10:40 |
"Topics on tetrodotoxin, saxitoxin, and their binding proteins"
Mari Yotsu-Yamashita |
| 10:40-10:45 |
Discussion |
| 10:45-11:00 |
Coffee |
| 11:00-11:20 |
Photograph |
| Natural Products from Marine Microorganisms |
| Discussion Leader: Fritz Schmitz |
| 11:20-12:00 |
"Bioactive metabolites from marine-derived microorganisms: the utility of LC/MS and LC/MSn"
Leonard McDonald |
| 12:00-12:05 |
Discussion |
| 12:05-12:25 |
"Scytonemin- marine natural product inhibitor of inflammation and cell proliferation"
Christopher Stevenson |
| 12:25-12:30 |
Discussion |
| 12:30 |
Lunch |
| 1:30 |
Free Time |
| Monday |
Afternoon |
| 4:30-6:00 pm |
Poster Session #1 |
| 6:00 pm |
Dinner |
| Monday |
Evening Session 7:30-9:30 pm |
| Marine Chemical Ecology |
| Discussion Leaders: Dale Nagle and Julia Kubanek |
| 7:30-8:15 |
"Chemical mediation of biological interactions at surfaces"
Peter Steinberg |
| 8:15-8:30 |
Discussion |
| 8:30-8:50 |
"Why are marine sponges immune to cytotoxins which they accommodate?"
Kazuo Tachibana |
| 8:50-9:00 |
Discussion |
| 9:00-9:20 |
"Metal binding selectivity and possible ecological roles of Lissoclinum patella metabolites"
Marcel Jaspars |
| 9:20-9:30 |
Discussion |
| 9:30-11:00 |
Poster Session #1 continued |
| TUESDAY, February 29 |
Morning Session 9:00 am-12:30 pm |
| Synthesis of Combinatorial Libraries of Marine Natural Products |
| Discussion Leader: Dick Moore |
| 9:00-9:40 |
"Solid-phase total synthesis of complex natural products: setting the stage for combinatorial synthesis of analogs"
Paul Grothaus |
| 9:40-9:50 |
Discussion |
| 9:50-10:30 |
"Synthesis and biological evaluation of a targeted library of curacin A analogs"
Peter Wipf |
| 10:30-10:40 |
Discussion |
| 10:40-11:00 |
Coffee |
| Marine Natural Products: Biological Activities and Applications |
| Discussion Leader: Fred Valeriote |
| 11:00-11:30 |
"Exploiting new bioassays to discover anticancer drug leads in marine natural product extract libraries"
Raymond Andersen |
| 11:30-11:40 |
Discussion |
| 11:40-12:00 |
"Targeting natural product cytotoxins to tumor vasculature"
Helene Vervoort |
| 12:00-12:05 |
Discussion |
| 12:05-12:25 |
"Development of the Pseudopterosins, a commercial skin care additive from the Caribbean gorgonian Pseudopterogorgia elisabethae"
William Fenical |
| 12:25-12:30 |
Discussion |
| 12:30 |
Lunch |
| 1:30 |
Free Time |
| Tuesday |
Afternoon |
| 4:30-6:00 pm |
Poster Session #2 |
| 6:00 pm |
Dinner |
| Tuesday |
Evening Session 7:30-9:30 pm |
| Collection, Conservation, and Aquaculture of Marine Invertebrates |
| Discussion Leaders: Linda Kupfer and David Newman |
| 7:30-7:50 |
"Population biology of Pseudopterogorgia elisabethae: ecology of a sustainable (?) coral reef resource"
Howard Lasker |
| 7:50-8:00 |
Discussion |
| 8:00-8:20 |
"Sustainable methods for collection and aquaculture of marine invertebrates for natural product production"
Dominick Mendola |
| 8:20-8:30 |
Discussion |
| 8:30-8:50 |
"Development of sponge cell culture models for in vitro production"
Shirley Pomponi |
| 8:50-9:00 |
Discussion |
| 9:00-9:20 |
"From bioprospecting to new marine reserves- marine natural products researchers and conservationists, an invaluable, obvious, and soon to be commonplace alliance"
Chris Battershill |
| 9:20-9:30 |
Discussion |
| 9:30-11:00 |
Poster Session #2 continued |
| WEDNESDAY, March 1 |
Morning Session 9:00 am-12:30 pm |
| Biosynthesis |
| Discussion Leaders: William Gerwick and Michelle Prinsep |
| 9:00-9:45 |
"Combinatorial biosynthetic potential from marine microorganisms"
David Sherman |
| 9:45-9:55 |
Discussion |
| 9:55-10:15 |
"Biosynthesis of cyclic peptides and depsipeptides from Nostoc spp. GSV224 and ATCC53789"
Dietmar Hoffmann |
| 10:15-10:20 |
Discussion |
| 10:20-10:40 |
"Biosynthesis of brevetoxin revisited: confirmation of previous results and new thinking"
Yuzuru Shimizu |
| 10:40-10:45 |
Discussion |
| 10:45-11:10 |
Coffee |
| Discussion Leader: Roy Okuda |
| 11:10-11:40 |
"Chemical signals from micro- and macroalgae: biosynthesis and ecology"
Wilhelm Boland and Georg Pohnert |
| 11:40-11:50 |
Discussion |
| 11:50-12:20 |
"Cyanide and thiocyanate-based biosynthesis in tropical marine sponges"
Mary Garson |
| 12:20-12:30 |
Discussion |
| 12:30 |
Lunch |
| 1:30 |
Free Time |
| Wednesday |
Afternoon |
| 4:30-6:00 pm |
Poster Session #3 |
| 6:00 pm |
Dinner |
| Wednesday |
Evening Session 7:30-9:30 pm |
| Advances in Instrumentation |
| Discussion Leaders: Steve Bobzin and Carole Bewley |
| 7:30-7:50 |
"Mining HPLC-MS data from large natural product extract libraries"
Richard Higgs |
| 7:50-8:00 |
Discussion |
| 8:00-8:20 |
"SMIDG-NMR: Doing more NMR quickly and with less stuff"
Gary Martin |
| 8:20-8:30 |
Discussion |
| 8:30-8:50 |
"Enhanced measurement and utilization of heteronuclear coupling constants in the structure elucidation of marine natural products"
Thomas Williamson |
| 8:50-9:00 |
Discussion |
| 9:00-9:20 |
"Constitutional assignment of marine natural products using ADEQUATE and COCON"
Matthias Köck |
| 9:20-9:30 |
Discussion |
| 9:30-11:00 |
Poster Session #3 continued |
| THURSDAY, March 2 |
Morning Session 9:00 am-12:30 pm |
| Symbiosis |
| Discussion Leader: Amy Wright |
| 9:00-9:45 |
"Bacterial symbionts and marine invertebrate natural products"
Margo Haygood |
| 9:45-9:55 |
Discussion |
| 9:55-10:15 |
"Accessing microbial diversity from marine invertebrates: prospects for drug discovery"
Brad Moore |
| 10:15-10:25 |
Discussion |
| 10:25-10:45 |
Coffee |
| Marine Natural Products and their Biological Activities |
| Discussion Leaders: Yoel Kashman and Tatsuo Higa |
| 10:45-11:05 |
"New calyculin derivatives: the structure-activity relationships for calyculins"
Toshiyuki Wakimoto |
| 11:05-11:10 |
Discussion |
| 11:10-11:30 |
"Recent findings on the mechanism(s) of action of discodermolide"
Ross Longley |
| 11:30-11:35 |
Discussion |
| 11:35-11:55 |
"Cell-permeant marine natural products that modulate ion-channels: an electrostatic model for IP3-sensitive Ca2+ channel blockade"
Tadeusz Molinski |
| 11:55-12:00 |
Discussion |
| 12:00-12:20 |
"The latest- and perhaps last- kulolides"
Paul Scheuer |
| 12:20-12:30 |
Discussion |
| 12:30 |
Lunch |
| 1:30 |
Free Time |
| Thursday |
Afternoon |
| 4:30-6:00 pm |
Poster Session #4 |
| 6:00 pm |
Dinner |
| Thursday |
Evening Session 7:30-9:40 pm |
| 7:30-8:30 |
Business Meeting
Valerie Paul and Alison Butler |
| Paul J. Scheuer Award Presentation and Lecture |
| 8:30-8:40 |
Introductory Remarks
Paul J. Scheuer |
| 8:40-8:45 |
Award Presentation
Robin Kinnel |
| Discussion Leader: Robin Kinnel |
| 8:45-9:30 |
Paul J. Scheuer Award Lecture: "Location, location, location"
D. John Faulkner |
| 9:30-9:40 |
Discussion |
| 9:40-?? |
Paul J. Scheuer Award Reception |
| 9:40-11:00 |
Poster Session #4 continued |
