Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Phytoplankton Chemical Cues and Toxins
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"Current Challenges in Marine Chemical Ecology Research: What Happens once Natural Products Leave the Organism that Made Them"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"NCCIH Program Priorities for Marine Natural Products – 2018"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Synthesis of Exposure Risks and Health Effects of the Marine Neurotoxin Domoic Acid from Studies with Fish, Mice, Sea Lions, and Humans"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
"Omic" Methods in Natural Product Research
9:00 am - 9:30 am
"Mining (Meta)genomes for New Peptide Modifications"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Preparative Mass Spectrometry: Novel Synthetic and Reaction Screening Approaches"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Untargeted Metabolomics Integrated with Bioassay Data for Natural Products Dereplication"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Computational Tools for Prioritizing Drug Discovery in Actinomycetes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Exploring the Biosynthetic Potential of Complex Microbial Communities"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Employing Stable Isotope Labeling to Connect Gene Clusters and Their Cognate Products: A Systems Approach"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic and Biosynthetic Advances in Natural Product Research
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:50 pm
"Natural Product Discovery in Burkholderia thailandensis Through Cryptic Gene Cluster Activation"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:05 pm
"Bacterial Signals Regulate Multicellularity and Mating in Animals' Closest Relative"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Bioactivity-Guided Retrosynthesis: Progressive SAR and Mode of Action Studies of Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Finding Drugs in the Garden: Mining Plant Chemical Diversity"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Identification and Pre-Clinical Development of Marine Natural Products
9:00 am - 9:30 am
"Biologically Active Metabolites from Marine Organisms and Their Associated Microorganisms"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Strategies for Studying Bioactive Marine Organisms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Labeling Natural Products in Complex Extracts"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Where Are and How to Find the Novel and Bioactive Secondary Metabolites"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Quantum Mechanical Prediction of Chiroptical Properties as an Aid for Structure Elucidation of Natural Products"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"A Chemical Genetics Approach to the Discovery of Marine Natural Product Drug Leads"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Developing the Next Generation of Pharmaceuticals
7:30 pm - 8:00 pm
"Anticancer Drugs of Marine Origin in Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Harnessing Genomic Information to Identify Natural Products with Novel Mechanisms of Action"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Mechanisms of Antibiotic Resistance Revealed by Global Genome Mining and Biosynthesis Gene Cluster Manipulation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Anti-Infective Research and Development"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanisms of Action and Molecular Targets
9:00 am - 9:30 am
"Marine Natural Products as a Source of New Drugs for Neglected Tropical Diseases"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The NCI Program for Natural Product Discovery"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Lessons from Nature in Predicting and Controlling Cell Permeability in Cyclic Peptides"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Secondary Metabolism in the Acid Mine Drainage Microbiome at Ely Copper Mine in Vershire, VT"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Gene Activation Strategies in Marine Endophytic Fungi"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Natural Product Payloads for the Next Generation of Antibody-Drug Conjugates in Clinical Trials"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Chemical Mediated Interactions
7:30 pm - 8:00 pm
"New Directions in Chemical Ecology on Coral Reefs"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Secondary Metabolite Modulation in Host-Symbiont-Pathogen Systems"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Widespread Biosynthesis of Defense Chemicals by Obligate Symbionts of Marine Organisms"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Model System for Antibiotics and the Physiology of Bacterial Competitive Fitness"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Methodological Advances in Natural Product Research
9:00 am - 9:30 am
"Lessons Learned from Mining 10,000 Actinobacterial Genomes for Phosphonic Acid Natural Products"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Learn from Microbial Intelligence for Avermectin Overproduction"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Tropodithietic Acid Producing Roseobacter Group Bacteria as Probiotics in Marine Aquaculture"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Discovery of the Biosynthesis of Domoic Acid in Pseudo-Nitzschia Diatoms"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Mycale Sponges Inherit Cytotoxin Producers Through Vertical Microbial Transfer"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Interspecies Interactions Between Bacteria Mediate Transcriptional Activation of an Otherwise Silent Biosynthetic Gene Cluster"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Marine Natural Products Research
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"The PharmaSea Project – Key Results and Influence on International Policy"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Introduction by Discussion Leader
8:30 pm - 9:15 pm
"Development of Promising Antiparasitic Leads from Marine Cyanobacterial Lipopeptides"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure