Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Cryptic Microbial Metabolites
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"The Ecology and Evolution of Natural Products in Marine Actinobacteria"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Microbial Biosynthesis of Heterocyclic Natural Products"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Unlocking the Chemical Potential of the Fungal Terpenome"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Marine Natural Products as Therapeutics and Molecular Probes
9:00 am - 9:30 am
"Chemistry-First Approach to Identify Novel Targets for Personalized Treatment in Lung Cancer"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Evolution and Therapeutic Application of Venom from Predatory Marine Snails"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Considerations for Development and Launch of a Successful Antibody-Drug Conjugate"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Turbinmicin, a New Antifungal with Potent In Vivo Efficacy Against Pan Resistant Candida auris and Aspergillus fumigatus "
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Chemically Rich Sponge Symbiont Identified by Single-Cell Genomics and Raman Microscopy"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"A SMART Approach for Natural Product Discovery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Tools in the Structure Elucidation Tool Box
7:30 pm - 8:00 pm
"Siderophores in Stereo: Targeting Structural Diversity in the Discovery of New Siderophores"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Preparation and Structural Elucidation of Sesquiterpenoid Marine Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Advanced NMR Methods for Structure Elucidation of Complex Organic Molecules"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Redefining the Role of NMR in the Structure Elucidation of Marine Natural Products"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Secondary Metabolite Biosynthesis, Enzymology and Genomics
9:00 am - 9:30 am
"Understanding the Bottlenecks in Cyanobacterial Natural Product Research"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Computational Omics of Microbial Biosynthetic Diversity: From Natural Product Discovery to Microbiome Ecology"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Biocatalysis and Complex Molecule Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Ascidian Microbiome Metagenomics: In Search of the Palmerolide Biosynthetic Gene Cluster"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Progress in α-N -Methylated RiPP Biosynthesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Synthase-Guided Single Cell Genomics"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Enhanced Screening and Discovery Platforms for Natural Products
7:30 pm - 8:00 pm
"National Program for Natural Product Discovery, Generation of a Prefractionated Library for High Throughput Screening"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Genomic and Spectroscopic Signature-Based Discovery of Bioactive Natural Products"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"IDBac: Bioinformatics Software for Microbial Drug Discovery Prioritization and Culturomics Characterization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Genome Mining-Guided Insights into Beta-Lactone Natural Product Biosynthesis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Development and Application of New Enabling Technologies
9:00 am - 9:30 am
"Crystalline-Sponge Method for Natural Products Chemistry and Drug Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Visualizing Chemical Communication in Host-Microbe Interactions with Imaging Mass Spectrometry"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"New Methods Enabling the Synthesis and Characterization of Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"DU8+: Structure Validation/Revision Made Easy with Fast and Accurate Computations of Nuclear Spin Coupling Constants and Chemical Shifts"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Total Synthesis of THF-Containing Marine Macrolides"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Development of NMR Tools to Discover Unique Natural Products in Complex Mixtures"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Mechanisms of Action and Molecular Targets
7:30 pm - 8:00 pm
"Pheno-Target Drug Discovery from Natural Products Using Native Mass Spectrometry"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"A Multidimensional Profiling Platform to Unlock the Mechanisms and Therapeutic Potential of MNPs"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"The NP3 Approach for Capture and Validation of Protein-Targeted Bioactive Natural Products: Recent Advances Using Marine Natural Products"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Metabolomics and Mass Spectrometry-Based Bioassay Development for Compound Discovery from Harmful Algal Blooms"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional and Ecological Roles of Natural Products
9:00 am - 9:30 am
"Mesophotic Marine Ecosystems: Inspiring Understudied Resource"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Interspecies Chemical Sensing in an Evolutionary Model and Potential Biocontrol Agent"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Chemoproteomic Approach for Target Discovery of Natural Products"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A Multi-Year Investigation into the Secondary Metabolite Composition of Trichodesmium Blooms"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Deep-Sea Coral Microbiomes as a Source for Novel Natural Products"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Genetic and Biochemical Reconstruction of Ozone-Depleting Bromoform Production by Marine Macroalgae"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Future Directions in Marine Natural Products Discovery
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:10 pm
"Expanding Marine Natural Product Genome Mining and Synthetic Biology Horizons"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Introduction by Discussion Leader
8:30 pm - 9:15 pm
"Sea Slugs, Slime and Coral Diseases: Chemical Ecology and Our Changing Ocean"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure