Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Developing Marine Natural Product Therapies
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:20 pm
"Host-targeted Antiviral Development, Treating the Current Pandemic and Preparing for the Next"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Thioesterase-Mediated O-Acetylation and Double Bond Formation in Peloruside Biosynthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Marine Natural Products and Antibody Drug Conjugates: A Journey from the Ocean’s Deep to the Clinic"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Climate Change, Marine Toxins and Environmental Solutions
9:00 am - 9:30 am
"Development of Marine-derived Sunscreens and Their Role in Ocean Conservation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"The Ecological Roles of Brominated Indole Alkaloids within Coccolithophore Blooms"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Solving the Mystery of Saxitoxin Biosynthesis in Dinoflagellates: Turn-over, Subcellular Localization and Regulation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Life on Plastic: Deciphering the Functions of Marine Microbes in the Plastisphere"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Metabolomics Approaches to Probe Probiotic Potential of Cultured Coral-associated Bacteria"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Metabolomic Insights into Parasite Diseases of Phytoplankton"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Biology for Natural Product Production and Engineering
7:30 pm - 8:00 pm
"Reverse Genetics and Synthetic Biology for Natural Product Discovery and Production"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Posttranslational Cyclophane Formation in Bacteria"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Pinpointing Building Blocks and Amino Acid Ligases in TLN-05220 Biosynthesis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Terpenoid Biosynthesis in Octocorals"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Biosynthetic Origin of Octocoral Terpenoids"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Super Resolution Imaging for Natural Product Mechanisms
9:00 am - 9:30 am
"Biomining New Tools For Analyzing and Controlling Complex Biological Systems"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Mapping Biological Processes Through Molecular Vibrations"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Molecular Basis for Substrate-selective Inhibition of Protein Secretion"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"High Resolution MAS NMR Methods for Metabolic Profiling of Intact Zebrafish Embryos Exposed to Harmful Algal Bloom Toxins"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Taking a Microscale Look at Symbiotic Interactions: New Metabolites from the Host–Microbe Interface"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Strategies for Natural Product Lead Development
7:30 pm - 8:00 pm
"Building Biological Performance Diversity and Chasing Challenging Targets for Probe and Drug Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Walking the Non-biogenic Path: Cyanobacterial Pseudo-natural Products"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Bioinspired 3D Printing of Complex Marine Natural Scaffold for Anticancer Lead Discovery"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"A Chemical Synthesis of Ritterazine B, A Marine Natural Product with Potent Anticancer Activity"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Computational Workflows for Natural Products Discovery
9:00 am - 9:30 am
"Spatial Mass Spectrometry and Data Analysis Approaches for Rational Drug Development"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"NP-Suite: New Tools to Process, Integrate and Annotate Mass Spectrometry and Bioactivity Data for Natural Products"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Machine Learning Methods for Discovering Natural Products from Large Mass Spectral Datasets"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Predicting Natural Product Activities with Machine Learning"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Conformational Analysis of Flexible Natural Products Based on Sparse Experimental Restraints"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Digging Through the Data: Pursuing the Ideal Natural Product Discovery Scenario"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Lead Discovery, Molecular Targets and Phenotypic Screening
7:30 pm - 8:00 pm
"Ecology-driven Approaches to Biosynthesis and Drug Lead Discovery"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Preclinical Evaluation of Marine Natural Products for Neuroscience Drug Development"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"A Mass Spectrometry-based High-throughput Platform for Natural Product Electrophile Discovery and Biological Screening"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Classifying Drugs Using Morphological Changes in Treated Tubercle Bacilli"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Natural Products in the Context of Microbiomes and Symbioses
9:00 am - 9:30 am
"The Role of Symbioses in Natural Product Discovery: Discoveries from Bacterial Symbionts of Shipworms"
9:30 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Sugars Dominate the Seagrass Rhizosphere"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"The Biosynthesis of Bacterial Tropone Natural Products Important for Marine Symbiotic Interactions Depends on a Novel Flavoprotein Dioxygenase Prototype"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Small Molecule-mediated Interactions in Symbiotic Systems"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Chemical Investigations into the Microbiota of Marine Egg Masses"
11:45 am - 11:50 am
Discussion
11:50 am - 12:20 pm
"Regulation of Specialized Metabolite Production in Complex Microbiome Systems"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Integrated Strategies for Marine Natural Products Discovery
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Integrating Metabolomics into Mechanism of Action Studies of Marine Natural Products"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 9:00 pm
"Challenges and Adventures During Sponge Natural Products Chemistry Discovery at UCSC: The Good, The Bad, and The Ugly"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure