Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Bioactive Molecules from Marine Sources
7:40 pm - 8:00 pm
"Deciphering Targets of Cyanobacterial Natural Products to Unlock Therapeutic Opportunities"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Signaling a Change: the Role of Natural Products in Shape-Shifting Haloarchaea"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Marine Natural Products and Analogs As Tools to Modulate Neuropathic Pain"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Discovery, Isolation, and Biological Activity of Highly Active Pyrroloiminoquinone Alkaloids from Alaska Using the Bycatch from NOAA’s Bottom Trawl Survey & Synthetic Strategies to Access Them"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Technological Developments to Spur New Discovery
9:00 am - 9:20 am
"Changing Paradigms in Marine Natural Product Research"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Elucidating Mechanisms of Natural Products from Cell Painting Morphologic Signatures"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"High Throughput Approaches for Screening and Dereplication"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Use of the IDBac Web Platform to Explore Microbial Collections, Generate Hypotheses, and Guide Natural Product Discovery"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Marine Biogeochemistry to Address Microbial Challenges
7:30 pm - 7:50 pm
"Do Marine Microbes Interact through Dissolved Chemical Currencies?"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Finding Metal-Binding Molecules: Native Electrospray Metabolomics & Beyond"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Sulfur Metabolites That Shape Marine Microbial Ecosystems"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Virus-Induced Lipid Modulation and its Large-Scale Consequences"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery of New Molecular Targets and Receptors
9:00 am - 9:20 am
"Expanding the Scope of Natural Product Discovery from Novel Chemical Structures to Novel Biological Functions"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Microbial Glycobiology at the Host-Microbe Interface"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Marine Natural Products as Chemical Probes for New Drug Target Identification"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"High-Resolution Cryo-EM Structures of Crosslinked PKS and NRPS Megasynthases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Integrative Synthetic Approaches for Enhanced Discovery
7:30 pm - 7:50 pm
"Recent Applications of Pharmacophore-Directed Retrosynthesis Driving Biological Studies of Natural Products"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Selectivity: A Key to Synthetic Efficiency"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"The Anti-Addictive Potential of the Aristotelia Alkaloids Revealed through Modular Synthetic Chemistry"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Overcoming the Barrier to Intermolecular Alkoxy Radical Reactivity"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Biosynthesis and Bioengineering for Molecule and Target Discovery
9:00 am - 9:20 am
"Engineering RiPPs into Preclinical Candidates"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Natural Product Peptides: New Chemistry to Enable Synthetic Biology"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Fermentation-Enabled Synthesis of Arylomycin Antibiotic Cores"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Nature’s Strategies for Chirality Editing in Diketopiperazines"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Discovery, Function, and Evolution of Efficient Halogenases from Marine Cyanobacteria"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Short Talk Selected from Poster Abstracts
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Informatics Challenges and Opportunities
7:30 pm - 7:50 pm
"Tackling Big Data Challenges in Natural Products - Computational Advances in Spectral Similarity Can Find Needles in Haystacks"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Using Reverse Metabolomics to Explore Biological Chemistry"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Exploration of AI/LLM Tools Using the Secondary Metabolism Collaboratory and JGI Data Ecosystem"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
Short Talk Selected from Poster Abstracts
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Symbiosis and Microbiome Interactions to Facilitate Discovery
9:00 am - 9:20 am
"Outer Membrane Vesicles as Tools for Space Biomanufacturing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Listianol: A Natural Product from a Methylotrophic Bacterium with Potential to Impact the Phyllosphere Microbiome"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Tracking HABs: Using the Microbiome’s Proteome to Pinpoint Ecosystem Shifts for More Targeted Metabolomics Analyses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Pseudomonas aeruginosa Alkylquinolones Trigger an Immune Response in the Closest Relatives of Animals"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Decoding Oxylipin Signaling in Coral–Algal Symbiosis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Talk Selected from GRS
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Talk Selected from GRS
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Integrative Strategies for Marine Natural Products Research
7:30 pm - 7:50 pm
"Logical Exploration of Targeted Natural Products via Metabologenomics and Synthetic Biology"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Introduction by Discussion Leader
8:20 pm - 9:10 pm
"Exploring the Ocean's Depth for Biosynthetic Novelty and Purpose"
9:10 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure