Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Network Function in the Normal and Diseased Brain |
| Discussion Leaders: Heinz Beck (University of Bonn Medical Center, Germany) and Steve Danzer (Cincinnati Children's Hospital Medical Center, USA) |
7:40 pm - 7:50 pm | Introduction by Discussion Leader |
7:50 pm - 8:25 pm | Gabor Tamas (University of Szeged, Hungary) "Similarities and Differences of Human and Rodent Synapses, Neurons and Networks in the Neocortex" |
8:25 pm - 8:40 pm | Discussion |
8:40 pm - 9:15 pm | Yehezkel Ben-Ari (Institut de Neurobiologie de la Méditerranée (INMED), INSERM, France) "Treating Autism Beyond Genes and Psychiatry. Is Delivery a Critical Period for the Pathogenesis of Autism?" |
9:15 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Network Dysfunction in Genetic Epilepsies |
| Discussion Leader: Jeffrey Noebels (Baylor College of Medicine, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Dirk Isbrandt (German Center for Neurodegenerative Diseases (DZNE), Germany) "Timed Treatments During Vulnerable Developmental Periods for Prevention of Epileptogenesis in Mouse Channelopathies" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Michael Wong (Washington University in St. Louis, USA) "Cell-Specific Contributions to Epileptogenesis in Tuberous Sclerosis: Neurons and Astrocytes and Microglia! Oh My!" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Christina Gross (Cincinnati Children's Hospital Medical Center, USA) "MicroRNA-Mediated Regulation of the Potassium Channel Kv4.2 During Seizures" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Holger Lerche (Hertie Institute for Clinical Brain Research / University of Tübingen, Germany) "Novel Genetic Defects in Epilepsy and Therapeutic Implications" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Ype Elgersma (Erasmus University, The Netherlands) "Mechanisms Underlying mTOR-Mediated Epilepsy in a Mouse Model of TSC" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Angel Lopez (Baylor College of Medicine, USA) "AnkG Isoform Imblance and Interneuronopathy Link Epilepsy and Bipolar Disorder" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Regulation
and Mis-Regulation of Neuronal Circuit Development |
| Discussion Leader: Kevin Staley (Harvard Medical School, USA) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:35 pm | Jack Parent (University of Michigan, USA) "Combining Human Cell and Rodent Models to Decipher Epileptic Encephalopathies" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Albert Becker (University of Bonn, Germany) "Loss of STE-20 Like Kinase as Emergent in Human Epileptogenic Malformations Impairs High-Order Dendrite Arborization and Inhibitory Synapse Maintenance" |
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:45 pm | Pierre-Pascal Lenck-Santini (Institut de Neurobiologie de la Méditerranée (INMED), INSERM, France) "Network Dynamics in Normal vs. Epileptic Brain" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Regulation of Neuronal Circuits by Astrocytes |
| Discussion Leader: Karen Wilcox (University of Utah, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Christian Henneberger (University of Bonn Medical School, Germany) "Rapid Astrocyte Morphology Changes During Epileptogenesis" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Nicola Allen (Salk Institute for Biological Studies, USA) "Astrocyte Regulation of Synaptic Glutamate Receptors" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Lauren Lau (Tufts University, USA) "Targeting Alpha-2-Delta-1 Prevents Pathological Synaptogenesis and Cell Death Following Neonatal Cortical Insult" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Catherine Christian (University of Illinois at Urbana-Champaign, USA) "Bidirectional Astrocytic Modulation of GABAAR-Mediated Synaptic Transmission" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Nathalie Rouach (Collège de France, France) "Unraveling the Role of Astroglial Networks in Neuronal Coordination" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Frances Cho (Gladstone Institutes, University of California, San Francisco, USA) "Selective Astrogliosis Increases Thalamic Circuit Excitability and Oscillations" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | GABAergic Circuit Function and Neuronal Oscillations |
| Discussion Leader: Douglas Coulter (Children's Hospital of Philadelphia, USA) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:35 pm | Scott Baraban (University of California, San Francisco, USA) "Functional Integration of GABA Progenitor Cells in Host Circuits" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Ilan Lampl (Weizmann Institute of Science, Israel) "A Novel Chemo-Optogenetic Model of Focal Epilepsy" |
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:45 pm | Laura Colgin (University of Texas at Austin, USA) "Slow and Fast Gamma Oscillations in the Hippocampus" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Normal Circuit Function in Cognition |
| Discussion Leader: Ivan Soltesz (Stanford University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Carol Barnes (University of Arizona, USA) "Memory Circuits in Normal Aging: Excitability and Adaptation" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Anton Sirota (Ludwig Maximilian University of Munich, Germany) "Anatomical Perspective on High-Frequency Oscillations in the LFP" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Jiadong Chen (University of California, San Francisco, USA) "Novel
GABAergic Long-Range Projection in Cortical Development and Disease" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Florian Mormann (University of Bonn, Germany) "Single Neuron Correlates of Perception and Memory in the Human Medial Temporal Lobe" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Ueli Rutishauser (Cedars-Sinai Medical Center, USA) "The Microcircuits of Human Declarative Memory: The Role of Theta-Mediated Coordination" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Michael Wenzel (Columbia University, USA) "In Vivo Population Imaging of Seizure Progression Within and Across Cortical Layers" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Pathological Circuit Function in Epilepsy |
| Discussion Leader: Viji Santhakumar (Rutgers New Jersey Medical School, USA) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:35 pm | Valerie Crepel (Institut de Neurobiologie de la Méditerranée (INMED), INSERM, France) "Pathophysiology of Temporal Lobe Epilepsy: Role of Ectopic Kainate Receptors" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Peyman Golshani (University of California, Los Angeles, USA) "Dentate Gyrus Interneuron Desynchronization in Epilepsy" |
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:45 pm | Liset Menendez de la Prida (Cajal Institute, Spanish National Research Council (CSIC), Spain) "Common Circuits of Hippocampal Rhythmopathies in Temporal Lobe Epilepsy" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Circuit Dysfunction in Epilepsy Comorbidities |
| Discussion Leader: Nigel Jones (University of Melbourne, Australia) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:35 am | Lennart Mucke (Gladstone Institute of Neurological Disease, University of California, San Francisco, USA) "Overlapping Mechanisms and Therapeutic Opportunities in Epilepsy and Alzheimer's Disease" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Jamie Maguire (Tufts University School of Medicine, USA) "Seizure-Induced Plasticity in the GABAergic Control of the HPA Axis: Relevance to Comorbid Depression" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:30 am | Aynara Wulsin (Cincinnati Children's Hospital Medical Center, USA) "Glucocorticoid Receptor Inhibition as a Novel Treatment for Epilepsy" |
10:30 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Tallie Z. Baram (University of California, Irvine, USA) "Circuit and Cellular Dysfunction Contribute to Cognitive Impairment After Febrile Status Epilepticus" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Laura Cancedda (Italian Institute of Technology, Italy) "Protocadherin 19 Downregulation Affects Hippocampal Development and Increases Seizure Susceptibility in Rats" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Julia Kahn (University of Pennsylvania, USA) "Epilepsy-Associated Dentate Granule Cell Hyperactivity Critically Contributes to Cognitive Comorbidities" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session |
6:00 pm - 8:00 pm | Using Circuit-Level Insights to Repair and Manipulate the Epileptic Brain |
| Discussion Leader: Istvan Mody (David Geffen School of Medicine, University of California, Los Angeles, USA) |
6:00 pm - 6:10 pm | Introduction by Discussion Leader |
6:10 pm - 6:35 pm | Esther Krook-Magnuson (University of Minnesota, USA) "Optogenetic Dissection of Circuits in Temporal Lobe Epilepsy" |
6:35 pm - 6:45 pm | Discussion |
6:45 pm - 7:10 pm | Jeanne Paz (Gladstone Institutes, University of California, San Francisco, USA) "Bi-Directional Control of Seizures by the Thalamus: Dravet Syndrome" |
7:10 pm - 7:20 pm | Discussion |
7:20 pm - 7:45 pm | Luke Lavis (Janelia Research Campus, Howard Hughes Medical Institute, USA) "From
Drugs to Dyes and Back Again" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:00 pm | General Discussion |
8:00 pm | Dinner |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |