| Session I. |
Burroughs Wellcome Opening Session |
| Cheryl Walker (UT MD Anderson) |
Introduction |
Debra Laskin (Rutgers Univ.)
Burroughs Wellcome Toxicology Scholar |
"Oxidants, Cytokines and Tissue injury" |
| Harry Ishirapolous (Univ. Penn) |
Nitric Oxide, Peroxynitrite and Oxidant Mechanisms of Tissue Injury
|
| Session II. |
Toxicant-induced Alterations in Gene Transcription |
| Chair: Ron Hines (Wayne St.) |
|
| Discussion Leader: Ken Ramos (Texas A&M) |
| Mike MacLeod (UT MD Anderson) |
Transcription Factor Hijacking and Disruption of Gene Expression by DNA Damage |
| Max Costa (NYU) |
Cap43, a New Gene Induced by Cellular Ca2+ Elevation Following Exposure to Ni2+ |
| Anil K. Jaiswal (Baylor Univ.) |
Antioxidant Regulation of Genes Encoding Enzymes that Detoxify Xenobiotics and Carcinogens |
| Glen Andrews (Univ. Kansas) |
Mechanisms of Metal Induction of Metallothionein Gene Expression by Metals
|
| Session III. |
Receptor-Mediated Toxicity |
| Chair: Holly Swanson (Univ. Kentucky) |
| Discussion Leader: Tom Sutter (Johns Hopkins Univ.) |
| Myles Brown (Dana Farber) |
Convergence of Chromatin Remodeling Factors in Estrogen Receptor Function |
| Chris Bradfield (McArdle) |
Dioxin Signal Transduction: Modeling the Other Nuclear Receptor Superfamily |
| Chris Glass (Univ. CA) |
Integration of Nuclear Receptor, JAK-STAT and AP-1 Dependent Transcription by CBP Coactivator Complexes
|
| Session IV. |
Endocrine Disruptors |
Chair: Mike Gallo (Robert Wood Johnson) |
| Discussion Leader: Jim Lamb (Jellinek, Schwartz & Connolly) |
| Dan Sheehan (NCTR) |
Low Dose Effects of Endocrine Disruptors |
| Tim Zacharewski (Michigan St. Univ.) |
In Vitro and In Vivo Identification and Assessment of Novel Endocrine Disruptors |
| Elizabeth Wilson (UNC) |
Molecular Mechanisms of Androgen Agonist and Antagonist Activity |
| Jonathan Lindzey (NIEHS) |
Effects of Endocrine Modulators in Estrogen Receptor-alpha Knockout (ERKO) Mice
|
| Session V. |
Late Breaking Research |
| Chair: Jerry Heindel (NIEHS) |
| Selected abstracts from conference attendees will be highlighted with oral presentations in this session
|
| Session VI. |
Genetic Susceptibility |
| Chair: Norman Drinkwater (McArdle) |
| Discussion Leader: Joanna Groden (U. Cincinnati) |
| Doug Bell (NIEHS) |
Polymorphisms and Disease: The Environmental Genome Project |
| Andrea McClatchkey (MGH Cancer Center) |
Modeling Genetic Susceptibility in the Mouse
|
| Alvaro Puga (Univ. Cincinnati) |
Ah receptor polymorphisms: novel approaches for genotype-phenotype correlations
|
| Session VII. |
Novel Technologies and Predictive Assays |
| Chair: Ray Tennant (NIEHS) |
|
| Discussion Leader: Elaine Faustman (Univ. Wash) |
| Paul Metzer (NIH) |
Gene expression profiling with cDNA microarrays |
| Maureen Cronin (Protogene Lab.) |
Novel Genetic Approaches for Assessing Toxicity |
| John Schimenti (Jackson Labs) |
Genetic Recombination in the Repair and Detection of DNA Damage in Mice
|
| Session VIII. |
Cell Signaling and Apoptosis |
| Chair: Jim Stevens (Adirondack Biomedical Res. Inst.) |
| Discussion Leader: Betsy Wattenberg (Univ. Minn.) |
| Peter Davies (UT Med. School) |
Transglutaminase Induction in Apoptotic Cells: Insights into the Biochemistry of Programmed Cell Death |
| Sten Orrenius (Karolinska Inst.) |
Biochemical Signals that Initiate Apoptosis |
| Mike Weber (Univ. Virginia) |
Kinase Cascades in Cell Growth and Death |
| Gerald Cohen (MRC) |
Caspase Cascades in Toxicant-Induced Cell Apoptosis
|
| Session IX. |
Conference Address |
| J. Carl Barrett (Scientific Director, National Institute of Environmental Health Sciences) |
