Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | The
Synaptonemal Complex: Formation, Structure, and Function |
| Discussion Leader: Michael Lichten (National Cancer Institute, NIH, USA) |
7:40 pm - 7:55 pm | Scott Hawley (Stowers Institute for Medical Research, USA) "Multiple Players Control the Assembly and Disassembly of the Synaptonemal Complex in Drosophila" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:15 pm | Amy MacQueen (Wesleyan University, USA) "On
the Relationship Between Synaptonemal Complex and Interhomolog Recombination" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:40 pm | Monica Colaiacovo (Harvard Medical School, USA) "Regulation of the Synaptonemal Complex in C. elegans" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Kim McKim (Rutgers University, USA) "Dynamic and Stable Cohesins Regulate Synaptonemal Complex Assembly and Chromosome Segregation" |
9:00 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Abby Dernburg (University of California, Berkeley, USA) "A Signaling Circuit that Designates and Constrains
Crossovers Operates Autonomously Within the Synaptonemal Complex" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Homologous
Recombination: Mechanisms, Integration and Regulation |
| Discussion Leader: Eva Hoffmann (University of Copenhagen, Denmark) |
9:00 am - 9:15 am | Douglas Bishop (The University of Chicago, USA) "Biochemical
Reconstitution of Meiotic Recombination" |
9:15 am - 9:25 am | Discussion |
9:25 am - 9:40 am | Jeremy Wang (University of Pennsylvania, USA) "Regulation of Meiotic Recombination by ssDNA-Binding Proteins" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Jeff Sekelsky (University of North Carolina at Chapel Hill, USA) "What Happens When All of Your Crossovers Are 2nd Class?" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Francesca Cole (University of Texas MD Anderson Cancer Center, USA) "Active Suppression of Mitotic Recombination Pathways Promotes Crossover Assurance in the Mouse" |
11:00 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Raphael Mercier (Institut National de la Recherche Agronomique, France) "Unleashing Meiotic Crossovers (or Turning Arabidopsis into Fission Yeast)" |
11:30 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Michael Lichten (National Cancer Institute, NIH, USA) "Regulation of Recombination Intermediate Metabolism During Meiosis" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Nancy Hollingsworth (Stony Brook University, USA) "Synaptonemal Complex Disassembly
Activates Rad51-Mediated Recombination During Budding Yeast Meiosis" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Meiotic Errors: Mechanisms and Clinical Implications |
| Discussion Leader: Matthew Neale (University of Sussex, United Kingdom) |
7:30 pm - 7:45 pm | Ian Adams (MRC Human Genetics Unit, United Kingdom) "Maintaining Sister Chromatid Cohesion and Preventing Aneuploidy in Post-Natal Mouse Oocytes" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Sharon Bickel (Dartmouth College, USA) "Damaged
Goods: Evidence that Oxidative Stress in Oocytes During Meiotic
Prophase Induces Premature Loss of Cohesion and Chromosome Segregation Errors" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:30 pm | Nancy Kleckner (Harvard University, USA) "Elevated Human Female Aneuploidy Results from a Programmed Defect in Crossover Recombination" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 8:55 pm | Caroline Sartain (Washington State University, USA) "Effects of Environmental Estrogens on Mammalian Meiosis" |
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Eva Hoffmann (University of Copenhagen, Denmark) "Chromosome Deterioration and Human Aneuploidy" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chromosome Segregation: Kinetochores, Cohesion, Chiasmata
and Spindles |
| Discussion Leader: Gloria Brar (University of California, Berkeley, USA) |
9:00 am - 9:15 am | Tomoya Kitajima (RIKEN Center for Developmental Biology, Japan) "Effects of Oocyte Size on Chromosome Segregation During Meiosis" |
9:15 am - 9:25 am | Discussion |
9:25 am - 9:40 am | Francis McNally (University of California, Davis, USA) "A Novel Chromosome Segregation Mechanism During Female Meiosis" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Adele Marston (University of Edinburgh, United Kingdom) "Regulation
of the Meiosis I to Meiosis II Transition" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Group Photo / Coffee Break |
10:45 am - 11:00 am | Yoshinori Watanabe (University of Tokyo, Japan) "Mechanisms of Chromosome Mono-Orientation in Meiosis I" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Akira Shinohara (Institute for Protein Research, Osaka University, Japan) "Prophase Pathway for Removal of a Meiosis-Specific Cohesin from Arms of Chromosomes During Late Prophase I of Meiosis" |
11:25 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Paula Cohen (Cornell University, USA) "Nima-Like
Kinase 1 (NEK1) Orchestrates a Prophase I Pathway for Cohesin Removal in Mammalian Meiosis" |
11:55 am - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Enrique Martinez-Perez (Imperial College London, United Kingdom) "Temporospatial Regulation of Aurora B Recruitment Controls the Two-Step Release of Sister Chromatid Cohesion" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Epigenetics, Germ Cells and Gametes |
| Discussion Leader: Joanne Engebrecht (University of California, Davis, USA) |
7:30 pm - 7:45 pm | Katja Wassmann (Institut de Biologie Paris-Seine (IBPS), Université Pierre-et-Marie-Curie, France) "How Oocytes Try to Get It Right: Mechanisms of Chromosome Segregation in Meiosis" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Satoshi Namekawa (Cincinnati Children's Hospital Medical Center, USA) "Programmed Gene Silencing During Meiosis: Mechanism and Function" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Gloria Brar (University of California, Berkeley, USA) "Non-Canonical Translation in Meiosis" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Mina Kojima (Whitehead Institute for Biomedical Research, USA) "Regulation of Gene Expression at Mammalian Meiotic Initiation" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Alex Bortvin (Carnegie Institution for Science, USA) "Transient Relaxation of DNA Methylation at the Onset of Male Meiosis in
Mice" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Checkpoints
and Regulation of Meiotic Progression |
| Discussion Leader: Adele Marston (University of Edinburgh, United Kingdom) |
9:00 am - 9:15 am | Sadie Sarah Wignall (Northwestern University, USA) "Regulation of Chromosome Segregation in C. elegans Oocytes" |
9:15 am - 9:25 am | Discussion |
9:25 am - 9:40 am | Attila Toth (Technische Universität Dresden, Germany) "HORMAD Proteins at the Interface of Chromosome Structure, Checkpoints and Recombination" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Kevin Corbett (University of California, San Diego / Ludwig Institute for Cancer Research, USA) "Assembly and Dynamics of the Yeast Meiotic Chromosome Axis" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Matthew Neale (University of Sussex, United Kingdom) "Spatial Patterning of Meiotic Recombination" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Franz K. Klein (Max F. Perutz Laboratories, University of Vienna, Austria) "Spo11 Releases Double Stranded DNA-Fragments from Meiotic Chromosomes in Mutant and Wild-Type Yeast" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Hong Ma (Fudan University, China) "The Arabidopsis CDC20.1 Gene Is Required for Normal Meiotic Spindle Assembly and Chromosome Segregation" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Rachel Wang (Academia Sinica, Taiwan) "The Mitosis-to-Meiosis Transition of Male Germline Is Controlled by Mac1 and Am1 in Maize" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Homologous Recombination: When, Where and How Many |
| Discussion Leader: Roberto Pezza (Oklahoma Medical Research Foundation, USA) |
7:30 pm - 7:45 pm | Bernard De Massy (Institute of Human Genetics, France) "A TopoVI-Like Complex Is Required for Meiotic DNA Double Strand Break Formation" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | Scott Keeney (Memorial Sloan Kettering Cancer Center, USA) "Breaking
and Chewing DNA" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Gregory Copenhaver (University of North Carolina, USA) "Modulators of Meiotic Recombination in Arabidopsis" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Monique Zetka (McGill University, Canada) "A Family of SUMO E3 Ligase-Like Proteins Are Required for Crossover Formation
in C. elegans" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Anne Villeneuve (Stanford University, USA) "Interplay Between Recombination and Chromosome Structure During C. elegans Meiosis" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
9:00 am - 12:30 pm | Meiotic
Chromosome Morphogenesis: Chromatin Organization, Chromosome Movement and Homolog
Pairing |
| Discussion Leader: Kevin Corbett (University of California, San Diego / Ludwig Institute for Cancer Research, USA) |
9:00 am - 9:15 am | Kikue Tachibana-Konwalski (IMBA - Institute of Molecular Biotechnology, Austria) "Novel Single-Cell Hi-C Reveals Unique Chromatin Reorganisation During the Mammalian Oocyte-to-Zygote Transition" |
9:15 am - 9:25 am | Discussion |
9:25 am - 9:40 am | Verena Jantsch (University of Vienna / Max F. Perutz Laboratories, Austria) "Reorganization
of the Nuclear Lamina During Meiotic Chromosome Movement in Caenorhabditis elegans" |
9:40 am - 9:50 am | Discussion |
9:50 am - 10:05 am | Julie Cooper (National Cancer Institute, NIH, USA) "Interplay Between Telomeres and Centromeres During Meiosis" |
10:05 am - 10:15 am | Discussion |
10:15 am - 10:45 am | Coffee Break |
10:45 am - 11:00 am | Denise Zickler (Institut de Genetique et Microbiologie, Université Paris-Sud, France) "From Synaptonemal Complex to Spindle Pole Body" |
11:00 am - 11:10 am | Discussion |
11:10 am - 11:25 am | Viji Subramanian (New York University, USA) "Control
of DNA Breakage and Repair in Meiosis" |
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Roberto Pezza (Oklahoma Medical Research Foundation, USA) "Control of Meiotic Double-Strand Break Repair by Chromatin Remodeling Complexes" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Gerald Smith (Fred Hutchinson Cancer Research Center, USA) "How Harmful Meiotic Recombination Around Centromeres Is Repressed" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Evolution
of Meiosis: Conservation and Diversity of Programs, Structures and Mechanisms |
| Discussion Leader: Kim McKim (Rutgers University, USA) |
7:30 pm - 7:45 pm | Joanne Engebrecht (University of California, Davis, USA) "Not All Germ Cells Are Created Equally: Sex-Specific Regulation of
Meiotic Recombination" |
7:45 pm - 7:55 pm | Discussion |
7:55 pm - 8:10 pm | R. Daniel Camerini-Otero (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) "Beyond DNA Sequence: The Importance of Context on Meiotic DSB Hotspot Location and Strength" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:35 pm | Peter van Dijk (KeyGene, The Netherlands) "Cloning the Apomeiosis Gene from Apomictic Dandelion (Taraxacum officinale)" |
8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:00 pm | Sarah Zanders (Stowers Institute for Medical Research, USA) "Meiotic Drive via a Gamete-Killing Poison and Antidote Encoded by a wtf Gene" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Sean Burgess (University of California, Davis, USA) "Positional Cues Within the Nucleus Underlie the Dynamic Chromosome Events
of Meiosis in Zebrafish" |
9:25 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |