Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Evolutionary Innovation in Meiosis
Discussion Leader: André Marques (Max Planck Institute for Plant Breeding Research, Germany)
7:40 pm - 7:55 pm
Meng Zhang (Max-Planck-Institute for Plant Breeding Research, Germany)
"Crossover Patterning Dynamics Under Chromosome Breaks and Fusions in Holocentric Rhynchospora Species"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
Leah Rosin (National Institutes of Health, United States)
"Meiotic Segregation in the Holocentric Pantry Moth Plodia Interpunctella Occurs Through a Unique Center-Kinetic Mechanism Independent of Bivalent Structure"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
Amanda Larracuente (University of Rochester, United States)
"Meiotic Drive in Drosophila"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Sarah Zanders (Stowers Institute for Medical Research, United States)
"WTF Recombination"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Luke Berchowitz (Columbia University Medical Center, United States)
"Gag-Derived Capsid Genes Prevent Age-Dependent Fertility Decline in Mammals"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chromosome Segregation and Aneuploidy
Discussion Leader: Federico Pelisch (University of Dundee, United Kingdom)
9:00 am - 9:15 am
Aimee Jaramillo-Lambert (University of Delaware, United States)
"Sexually Dimorphic Meiotic Programs Create Specialized Gametes"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Joshua Bembenek (Wayne State University, United States)
"Cytoplasmic Kinetochore Filaments Regulate Vesicle Transport in C. Elegans Oocytes"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Binyam Mogessie (Yale University, United States)
"Deciphering Chromosome Segregation in Mammalian Eggs"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Karen Schindler (Rutgers, The State University of New Jersey, United States)
"Decoding the Egg: Determining the Contribution of Kinesin Variants to Egg Aneuploidy"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Philip Jordan (Uniformed Services University of the Health Sciences and Johns Hopkins University, United States)
"Mammalian Spermatocytes Have the Capacity to Segregate Chromosomes Despite Centriole Duplication Failure"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Melina Schuh (Max-Planck-Institut für Multidiziplinäre Naturwissenschaften, Germany)
"The Maintenance of Oocytes in the Mammalian Ovary Involves Extreme Protein Longevity"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Eva Hoffmann (University of Copenhagen, Denmark)
"Molecular Mechanisms Mediating Chromosome Stability in Human Eggs"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Thomas Robert (CNRS, France)
"The SMC-Condensin Subunit NCADP2 is a New Regulator of Prophase I Chromosome Assembly and Homologous Recombination in the Mouse"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Aimee Jaramillo-Lambert (University of Delaware, United States) and Anne Villeneuve (Stanford University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Meiotic Spindle Assembly
Discussion Leader: Ahmed Balboula (University of Missouri, United States)
7:30 pm - 7:45 pm
Elvan Böke (Centre for Genomic Regulation (CRG), Spain)
"Evading Ageing: Mitochondrial and Proteostatic Adaptations in Oocytes"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Sadie Wignall (Northwestern University, United States)
"Mechanisms That Maintain Spindle Integrity in Oocytes"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Hiro Ohkura (The University of Edinburgh, United Kingdom)
"Meiotic Spindle Assembly in Oocytes"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Kim McKim (Rutgers, United States)
"HP1 Interacts with the Chromosomal Passenger Complex to Promote Spindle Assembly and Chromosome Segregation in Drosophila Oocytes"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Francis McNally (University of California, Davis, United States)
"Oocyte Meiotic Spindle Translocation Mediated by Organelle Exclusion"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Meiotic Chromosome Architecture: Pairing and Synapsis
Discussion Leader: Lexy von Diezmann (University of Minnesota, United States)
9:00 am - 9:15 am
Shuangqi Wang (University of Illinois Urbana-Champaign, United States)
"Meiotic Silencing is Regulated by Gel-Like Phase Separation, but Not by Chromatin Synapsis Status"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Lena Skrutl (ETH Zurich, Switzerland)
"Pericentromeric Satellite DNA Repeats Stabilize Centromere Pairing Between Homologous Chromosomes During Meiosis"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Katie Billmyre (University of Georgia, United States)
"Targeted Disruption of SYCP1 N-Terminal Self Assembly During Mouse Meiosis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Ofer Rog (University of Utah, United States)
"The Synaptonemal Complex Assembles Between Meiotic Chromosomes Through Adsorption"
10:15 am - 10:20 am
Discussion
10:20 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:15 am
Yumi Kim (Johns Hopkins University, United States)
"The Synaptonemal Complex in C. Elegans "
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Swathi Arur (University of Texas MD Anderson Cancer Center, United States)
"Orchestration of Spatial Signaling and Differentiation: Nutritionally Dependent ERK Signaling and Female Meiosis I Progression"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Joao Matos (Max Perutz Labs, University of Vienna, Austria)
"Holliday Junctions and the Synaptonemal Complex: Partners in the Maintenance of Meiotic Chromosome Synapsis"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Enrique Martinez-Perez (MRC Laboratory of Medical Sciences, Imperial College London, United Kingdom)
"Investigating Functional Specialization of Meiosis Specific Kleisins and HORMAD Proteins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Meiotic Checkpoints and Cell Cycle Regulation
Discussion Leader: Maria Mikedis (Cincinnati Children's Hospital Medical Center, United States)
7:30 pm - 7:45 pm
Soni Lacefield (Geisel School of Medicine at Dartmouth, United States)
"Understanding Meiosis II Regulation"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Paula Cohen (Cornell University, United States)
"New Perspectives on Meiotic Sex Chromosome Inactivation (MSCI) and the Sex Body of the Pachytene Spermatocyte"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Kei-ichiro Ishiguro (Institute of Molecular Embryology and Genetics, Kumamoto University, Japan)
"The Mechanisms Underlying the Transcriptional Activation of Meiotic Genes by the STRA8-MEIOSIN Complex"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:00 pm
Ignasi Roig (Universitat Autònoma de Barcelona, Spain)
"Preservation of Ovarian Reserve in Mice Through SKQ1 Treatment"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Arp Schnittger (University of Hamburg, Germany)
"Meiosis Under Heat"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Initiation of Recombination: Induction and Regulation of DSBs
Discussion Leader: Sue Hammoud (University of Michigan, United States)
9:00 am - 9:15 am
Rachel Cosby (Eunice Kennedy Shriver National Institute of Child Health and Human Development, United States)
"Uncovering Principles and Consequences of Mammalian Recombination Hotspot Evolution by Mapping PRDM9 Binding"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Agnieszka Lukaszewicz (University of Michigan Medical School, United States)
"MRE11 Suppresses Germline Mutagenesis at Recombination Hotspots in Mice"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Michael White (University of Georgia, United States)
"A Sexually Dimorphic Chromatin Landscape May Underlie Heterochiasmy in the Threespine Stickleback Fish"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Monica Colaiacovo (Harvard Medical School, United States)
"Histone Methylation is Linked to Crossover Site Designation for Productive Late Prophase I Chromosome Remodeling During C. Elegans Meiosis"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
Corentin Claeys Bouuaert (Université catholique de Louvain, Belgium)
"In Vitro Reconstitution of Meiotic DNA Double-Strand-Beak Formation"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
Scott Keeney (Howard Hughes Medical Institute / Memorial Sloan Kettering Cancer Center, United States)
"Structural and Biochemical Studies of Meiotic Recombination Initiation by SPO11"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
Diana Libuda (University of Oregon, United States)
"Regulating the Sexually Dimorphic Recombination Landscape During C. Elegans Meiosis"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Gerald Smith (Fred Hutchinson Cancer Center, United States)
"A Molecular Mechanism for Meiotic DSB, Crossover, and Gene Conversion Interference"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Meiotic DSB Repair
Discussion Leader: Cori Cahoon (Colorado State University, United States)
7:30 pm - 7:45 pm
Ayelet Arbel-Eden (Hadassah Academic College, Israel)
"Enhanced Mutagenicity During Meiosis: The Involvement of DNA Repair and Recombination Genes"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Valerie Borde (Institut Curie , France)
"Control and Fidelity of DNA Synthesis During Meiotic Recombination"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
Douglas Bishop (The University of Chicago, United States)
"Making Dmc1 Run: Mechanism of Dmc1 Activation by Mei5-Sae3"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Piotr Ziolkowski (Adam Mickiewicz University, Poznan, Poland)
"Anti-Crossover Functions of MMR and ZMM"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Raphael Mercier (Max Planck Institute for Plant Breeding Research, Germany)
"The Regulation of Crossover Numbers and Distribution"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Control of Number and Distribution of Crossovers
Discussion Leader: Nicole Crown (Case Western Reserve University, United States)
9:00 am - 9:15 am
Tegan Horan (Cornell University, United States)
"Sex and Strain Differences in the Accumulation of Pro-Crossover Factors During Mouse Prophase I"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Francesca Cole (University of Texas MD Anderson Cancer Center, United States)
"Defective Crossover Homeostasis Compromises Chromosome Segregation in Aged Mouse Spermatocytes"
9:40 am - 9:45 am
Discussion
9:45 am - 10:00 am
Abby Dernburg (University of California, Berkeley, United States)
"A Maternal Age Effect on Meiosis in C. Elegans "
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
Eric Alani (Cornell University, United States)
"Exo1 Protects DNA Nicks from Ligation to Promote Crossover Formation During Meiosis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Nancy Kleckner (Harvard University, United States)
"Pairing, Patterning and Their Functional Interplay"
11:15 am - 11:25 am
Discussion
11:25 am - 11:40 am
Neil Hunter (University of California, Davis, United States)
"Protecting Recombination Intermediates to Ensure Chromosomal Crossing Over During Meiosis"
11:40 am - 11:45 am
Discussion
11:45 am - 12:00 pm
Anne Villeneuve (Stanford University, United States)
"Meiosis in C. Elegans "
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
Ian Henderson (University of Cambridge, United Kingdom)
"Recombination and the Arabidopsis Centromeres"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetics and Gene Expression
Discussion Leader: Devanshi Jain (Rutgers University, United States)
7:30 pm - 7:45 pm
Merrick Pierson Smela (Harvard University, United States)
"Induction of Meiosis in Human Pluripotent Stem Cells by Expression of Regulatory Factors"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
Aurora Ruiz-Herrera (Universitat Autonoma Barcelona, Spain)
"Divergent Patterns of Meiotic Chromosome Remodeling"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
Yasuhiro Fujiwara (The University of Tokyo, Institute for Quantitative Biosciences, Japan)
"SETX is A Master Transcriptional Mediator During Meiotic Prophase"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Gloria Brar (University of California, Berkeley, United States)
"Protein Complex Assembly in Meiotic Cells"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
Roberto Pezza (Oklahoma Medical Research Foundation, United States)
"Homologous Interchromosomal Dynamics in Mouse Meiosis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure