Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Membrane Integration and Removal of Helical Membrane Proteins
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Translocon Recognition and Membrane Stability of Transmembrane Helices"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"In-Situ Observation of Membrane Protein Insertion and Folding During Cell-Free Expression by SEIRAS"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Mechanism of ER-Associated Protein Degradation (ERAD)"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Biophysics of Helical Membrane Protein Folding
9:00 am - 9:25 am
"Folding Alpha Helical Membrane Proteins: Thermodynamics, Lipid Bilayer Mechanics and Co-Translational Folding"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"BLaTM, a Genetic Tool to Measure Homo- and Heterotypic Parallel and Antiparallel Transmembrane Helix-Helix Interactions"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Observing the Insertase-Assisted Insertion and Folding Steps of Single Membrane Proteins"
10:15 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Folding of ClC Chloride Transporter Retains Memory of Its Evolutionary History"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Hidden Dynamics in the Unfolding of Individual Bacteriorhodopsin Proteins"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Mechanism by Which Lipids Shape Reaction Coordinates of Rhomboid Proteases"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Biophysical and Biochemical Insights into Caveolin-1"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Protein Structure Prediction and Design
7:30 pm - 7:55 pm
"Simulating Membrane Protein Folding from Limited Experimental Data"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"An Energy Function for Design and Structure Prediction in Membrane Proteins"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Enhancing Membrane Protein Structure Prediction and Design with Explicit Solvent-Protein Interactions"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Predictive Energy Landscapes for Folding Membrane Proteins"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Membrane Protein Folding in Disease
9:00 am - 9:25 am
"Elucidation of Bottlenecks in the Quality Control and Cellular Trafficking of PMP22"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"NMR Methods to Study the Structure and Folding of GPCRs"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Rational Design of Membrane Curvature Sensors"
10:15 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Refolding of E. coli Expressed GPCR into Nanodisks Using Amphipols"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Structural and Proteostatic Determinants of CFTR Functional Expression at the Cell Surface"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"smFRET Reveals Structural Basis for Conformational Misfolding of a Cystic Fibrosis Mutation in CFTR"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Correcting CFTR Protein Processing and Trafficking to Treat the Underlying Cause of Cystic Fibrosis"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Protein Stabilization
7:30 pm - 7:55 pm
"Novel Detergent Tools for GPCR Structural Study"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Protein-Surfactant Interactions Do Determine Fold"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"An Improved Rosetta Energy Function for Predicting Mutation-Induced Stability Changes in Membrane Proteins"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Folding of Beta Barrels and Others
9:00 am - 9:25 am
"Driving Forces for Sorting and Folding of Outer Membrane Proteins"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Systematic Analysis of Symmetry in Membrane Proteins"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
"The Biogenesis and Quality Control of Beta Barrel Outer Membrane Proteins as Explored in Living Cells"
10:15 am - 10:25 am
Discussion
10:25 am - 10:35 am
"Synthetic Molecular Evolution of Membrane Active Peptides"
10:35 am - 10:40 am
Discussion
10:40 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Interface Energetics and Beta Barrel Folding"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Dynamic Protein-Membrane Complexes: NMR and Simulation Studies on Transmembrane Receptors and Ras GTPases"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Mechanistic Insights into Outer Membrane Protein Folding"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Membrane Protein Folding in Amyloid Disease
7:30 pm - 7:55 pm
"Amyloid Proteins - Membrane Interactions: The Influence of the Lipid Composition on the Kinetics of Aggregation"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Mechanisms of Abnormal Aggregation and Toxicity of Alzheimer's Amyloid Beta-Protein on Neuronal Membranes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Isoleucine-Rich Amphipathic Peptides Bind Significantly Better to Lipid Bilayers than Leucine-Rich Peptides"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Membrane Interactions and Amyloid Formation of α-Synuclein"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Assembly of Membrane
Protein Complexes
9:00 am - 9:25 am
"The Role of pH in Modulating Membrane Protein Structure and Function"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Screening and Crystallographic Analysis of Intramembrane Helix Interactions Using Lipidic Cubic Phase (LCP) Techniques"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
"Resolving the Dimerization Interface of Visual Opsins with PIE-FCCS"
10:15 am - 10:25 am
Discussion
10:25 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Peptide-Based Approaches to Inhibiting Protein-Protein Interactions in Membranes"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Probing Membrane Protein-Lipid Interactions by Native Ion Mobility Mass Spectrometry"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Understanding Transmembrane Signal Transduction in Bacterial Histidine Kinases"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Protein Design for Disease Therapy
7:30 pm - 7:55 pm
"Building Transmembrane Proteins with Minimal Chemical Complexity"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Heterodimerization of Receptor Tyrosine Kinases in Health and Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Thermodynamics of Transmembrane Domains Can Be Exploited to Manipulate TNF Receptor Function"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"pHLIP®: Uses in Measuring Cell Surface pH, Imaging Tumors, and Delivering Therapeutics"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure