Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Geobiochemistry and Metals at The Origins of Life
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Leveraging Extracellular Electron Transfer to Understand the Biology of Stasis"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Coordinating the Assembly of Multiple Nickel-Dependent Enzymes in Methanogenic and Methanotrophic Archaea"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"A Revised Mechanism for Carbon Monoxide Dehydrogenases"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Metallosensors, Metallotherapeutics, and Nanochemistry in Biology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Backgroundless Chemistry for Bioconjugation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Investigating Metallocomplexes as Immunogenic Cell Death Inducers for Cancer Therapy"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Nature-Inspired Approaches to Metal-Based Diagnostics and Therapeutics"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Texas-Inspired Drug Discovery Efforts"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Heme Proteins: Structure, Spectroscopy, and Reactivity
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"The Rise, Fall, and Return of Mid-Valent Heme Intermediates: Modeling Crucial Aspects in Biology and Catalysis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Heme-Dependent Enzymes in Natural Products Biosynthesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Cytochrome P450 Compound I: Is It Really a Blow Torch? Novel Intermediates and the Thermodyamics of C-H Bond Cleavage"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New Metallocofactors, Motifs, and Transformations
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Unlocking New Possibilities for Transition Metal Catalysis in Nonheme Enzymes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"How Ascorbate Tunes the Activity and Selectivity of Fe(II)-Dependent Dioxygenases"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Stereoselective Radical Biocatalysis Using Heme and Nonheme Enzymes"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Characterization of the Carotenoid Oxygenase Iron Center: Role of Coordination Site Occlusion in Catalysis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Late-Breaking Topic
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Redox Flux and Homeostasis in Biology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Loz1 in Zinc Homeostasis: Conventional and Unconventional Regulatory Roles"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Diverse Reactivity of Molybdenum Dependent DMSO Reductase Family Enzymes"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Late-Breaking Topic
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Methodological Advances for Studying Metals in Biology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Elucidating Electron Transfer Pathways of Iron–Sulfur Proteins via Solution NMR"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Throwing Oxygen at The Goblin's Ore and Old Nick's Copper"
10:05 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Enhancing Insights into Metalloproteins via EPR Spectroscopy"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Dioxygen Activation and Intermediates in Fe Enzyme Catalysis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Where "Omics" Meets Metals
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Heme Oxygenase-Like Enzymes in Antibiotic Biosynthesis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"About Nickel-Pincer Nucleotide Cofactors: Why Would So Many Organisms Go to the Trouble of Making Such Fancy Cofactors?"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Late-Breaking Topic
8:45 pm - 8:55 pm
General Discussion
9:10 pm - 9:20 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Nitrogenases and their Reducing Relatives
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Mechanistic Insights into Metal-Protein Interactions: Implications for Neurodegenerative Disease Progression and Intervention"
9:30 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Transcending the Membrane: Long-Range Quinone Transport Couples Diverse Metalloenzymes to Microbial Respiratory Chains"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:10 am
"Functional Nitrogenase Models with Native and Non-Native Substrates"
11:10 am - 11:20 am
Discussion
11:20 am - 11:45 am
"Nitrogenase-Like Systems with Complex Iron-Sulfur Metallocofactors that Reductively Cleave Diverse Organic-Sulfur Compounds for Bacterial Sulfur Acquisition"
11:45 am - 11:55 am
Discussion
11:55 am - 12:20 pm
"Synthetic Iron-Nickel-Sulfur Clusters for Insight into the C-Cluster of CO Dehydrogenase"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Useful Applications of Bioinorganic Chemistry
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Surface Display of Multicopper Oxidases as Microbial Platforms for Selective Electrocatalysis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Thermodynamic Insights into the WT and Y220C TP53 DBDs Reveals that the Oncogenic Y220C Variant is a Loss of Function Mutation for Zn2+-Binding at Physiological Temperature"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Harnessing the Tenets of Bioinorganic Chemistry in Technology Development for Biomedicine and the Environment"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure