Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: The MHC Immunopeptidome
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:25 pm
"T Cell Recognition of Self Antigens in Human Neurodegenerative Disease"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"MHC Class I Molecules by Numbers"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Generating and Loading MHC Peptides
9:00 am - 9:20 am
"Viral Negative Strand Translation for Immunosurveillance"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Dynamic Aspects of MHC Peptide Loading and Exchange"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Exploring the MHC Class II Antigen Processing Landscape with Biosynthesized Proteins"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Friendly Faces in New Places: Expanding Nature's Repertoire of Antigen Processing Components for Immunotherapy Applications"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"The Complexity of Antigen Processing and Recognition Machineries"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Non-Classical MHC Molecules
7:30 pm - 7:50 pm
"Antigen Presentation of Unconventional MHC class I Molecules"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"The Role of the H2-O-Dependent Pathway in Viral and Bacterial Infections"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"MR1 Antigen Presentation: Cells, Mechanisms and Regulation"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diversity of the MHC Immunopeptidome
9:00 am - 9:20 am
"Variations in MHC Class I Antigen Processing Mechanisms in Bats"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Antigen Presentation in Autoimmune and Autoinflammatory Disease"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"HLA Class I Functional Divergence"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"What Shapes Immune Resilience: Lessons from Antigen Presentation in Infection and Cancer"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"MHC I Pathway Gene Regulation and Cancer Immune Evasion"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Antigen Cross Presentation
7:30 pm - 7:50 pm
"Mechanisms of WDFY4-Dependent Cross-Presentation by cDC1"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Cross-Presentation of Dead Cell-Associated Antigens by Dendritic Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Canonical and Noncanonical Routes to Cross-Presentation and CD8 T Cell Priming"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
MHC Immunopeptidome: Foreign Pathogens and the Self-Microbiome
9:00 am - 9:20 am
"Gut Immune Homeostasis Mediated by Dedicated Antigen Presenting Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Factors Regulating an MHC-E-Restricted T Cell Response to Influenza Virus"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Distinguishing Friend from Foe: Antigen-Presenting Cells in Intestinal Immunity and Tolerance"
11:05 am - 11:15 am
Discussion
11:15 am - 11:25 am
Short Talk Selected from Poster Abstracts
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Late-Breaking Topic
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"RORγt⁺ Antigen-Presenting Cells Orchestrate Oral Tolerance"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Autoimmune MHC Immunopeptidomes
7:30 pm - 7:50 pm
"Functional Interaction Between STING and the UPR Regulates Self-Antigen Presentation: Relevance for Parkinson's Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"A Conserved Insulin Neoantigen Drives Persistent Memory T Cell Activation in Type 1 Diabetes"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Late-Breaking Topic
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Cancer MHC Immunopeptidome
9:00 am - 9:20 am
"Aberrant Splicing Generates Tumor-Specific Antigens"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Short Talk Selected from Poster Abstracts
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Venturing into the Unknown: How Non-Canonical Open Reading Frames Expand Tumour Immune Visibility"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"mRNA Vaccines for Cancer"
11:05 am - 11:15 am
Discussion
11:15 am - 11:35 am
"From Discoveries to Therapy: Overcoming Challenges in Neoantigen-Based Cancer Immunotherapy"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"B Cell Dependent Regulatory T Cells"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tolerogenic MHC Immunopeptidomes
7:30 pm - 7:50 pm
"MHC-Dependent Regulatory Cell Circuits in the Intestine"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Short Talk Selected from Poster Abstracts
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Human Thymic Selection and Development of Autoreactivity, Alloreactivity and Xenoreactivity"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Sterile Inflammation Activates Antigen Presenting Cells in the Thymus"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure