The Evolutionary Past and the Synthetic Future of Microbial C1-Transformations at the Cross of Organic and Inorganic Worlds

C1-transforming microbes were architects of the Earth's habitability. They play a crucial role in influencing the biogeochemical cycles of vital elements, including carbon, nitrogen, sulfur, iron, and other essential minerals such as copper, rare earth elements, molybdenum, and nickel. The 2026 C1 Gordon Research Conference will focus on recent developments in understanding the relationship between microbial C1 metabolism—both native and synthetic—and other key biological or abiotic transformations. The conference will emphasize novel discoveries related to the evolutionary history of microbial C1 metabolism and explore C1 metabolism across different scales, from enzymes and cofactors to their subcellular organization, cellular assemblies, and the interaction of C1-transforming microbes with the living and non-living environment. We will seek to understand the natural limitations of these transformations and highlight innovative strategies to design and implement new-to-nature solutions for various applications, such as capturing greenhouse gases (CO2, CH4, N2O), enabling novel biocatalysis, and recovering critical minerals to support modern technological advancements.

The 2026 C1-GRC conference, along with its associated GRS, will once again unite early career and senior researchers, academics, and industry professionals from the C1 research community. Investigators who are new to the field are encouraged to apply. The GRC format—featuring extensive discussions, interactive poster sessions, and informal gatherings in the afternoons and evenings—will provide an ideal environment for investigators from various fields and generations to exchange ideas, brainstorm, and explore opportunities for collaboration.