Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Construction of Mitochondria
This session will open the meeting and emphasize mitochondrial lipid biology. Mitochondria contain a diverse collection of lipids and this session calls attention to the latest developments in lipid metabolism.
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
"Molecular Dissection of Ceramide-Mediated Apoptosis Using Photo-Activated Lipid Probes"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Mitochondrial Membrane Musings: Cardiolipin"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Mitochondrial Phosphoinositides. Do They Exist and What For?"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondrial Transfer and Positioning
This session investigates questions in positioning of mitochondria in polarized cells such as neurons.
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"In Vivo Dynamics and Diversity of Mitochondria in the CNS"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Regulation of Mitochondrial Trafficking and Turnover by the Mitochondrial GTPases Miro1 and Miro2"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Myosin 19 Facilitates Mitochondrial Transfer and Filopodia Formation Under Stress"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
"INF2, an Actin Polymerization Factor that Promotes Mitochondrial Division, Is Regulated by Protein Acetylation"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Structural Basis of Drp1-Cardiolipin Interactions in Mitochondrial Fission"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Roles for PI(4)P in Mitochondrial Division"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondrial Fatty Acid Synthesis Is a Master Regulator of Oxidative Phosphorylation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Contact Formation and Function
This session will highlight the latest developments in contacts between mitochondria and other organelles such as the endoplasmic reticulum and lysosomes.
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"In Vivo Analysis of the Mitochondria-Wrapping Rough-ER"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"MOSPD2, a New 'VAP Protein', Builds ER-Organelle Membrane Contact Sites"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"ER/SR Contacts and Inner Membrane Protein Distribution"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Heterogeneity of Membrane Potential Along the Individual Mitochondrion Reveals Single Cristae as Independent Bioenergetics Units"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Membrane Dynamics and Exchange of Contents
This session will report on topics in mitochondrial dynamics, including fission and fusion pathways.
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Expediting Mitochondrial Dynamics Reverses Genetic Neurodegeneration"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Intermitochondrial Junctions and Nanotunnels"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"OPA1-Domain Specific Disease-Causing Mutants Distinctly Alter Mitochondrial Bioenergetics"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Mtch2 Modulates Mitochondria ER Communication for Life and Death Decisions"
10:40 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
"ER-Mitochondrial Contact Cites Act as a Platform for Morphological Decision Making"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Oxidative Bursts of Single Mitochondria Generate Interorganelle Signals to Regulate Local Ca2+ Dynamics"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mitochondrial RNA Granules: Liquid Organelles in the Organelle?"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling: Mitochondrial Surface and Intermembrane Space Signaling Pathways
This session will investigate signaling pathways at the outer membrane and intermembrane space for metabolism and apoptosis.
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Dual Regulation of Mitochondrial Apoptosis and Fatty Acid Oxidation by the Pro-Survival Protein MCL-1"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"MTCH2-Dependent Control of Mitochondrial Morphology"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Cholesterol-Rich Mitochondrial-Nuclear Contacts (CRiMiNls) Regulate Retrograde Signalling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Mitochondrial Pyruvate Handling and Cellular Responses to Inflammation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Signaling: Calcium and ROS
This session will investigate signaling pathways that utilize calcium and ROS.
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Mitochondrial Calcium in Genetic Reprogramming"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"F-ATP Synthase and the Permeability Transition Pore"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Loss of Mitochondrial Calcium Uniporter Rewires Skeletal Muscle Metabolism and Substrate Prreference"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"How Many Mitochondrial Uncoupling Proteins Are There?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Mitochondrial Transporter ABCB10 in Liver Amplifies a Redox Cycle that Drives Hyperglycemia in Obesity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Genomic Effects of ATPIF1 Loss"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
New Technologies for Mitochondrial Biology and Medicine
7:30 pm - 7:50 pm
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Cristae and Crista Junctions Dynamics Revealed by Live-Cell Stimulated Emission Depletion (STED) Super-Resolution Nanoscopy"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Defining Mitochondrial Protein Function Through Systems Biochemistry"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"What Metabolomics Tells About the Pathophysiology of Mitochondrial Optic Nerve Diseases"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
"SFXN1 Is a Mitochondrial Serine Transporter Required for One-Carbon Metabolism"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Why Are There so Many Matrix Acots?"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Mitochondria and Striated Muscle Membrane Repair"
10:05 am - 10:15 am
Discussion
10:15 am - 10:35 am
"Unfolded Protein Response and Mitochondrial Dysfunction in Neurodegenerative Disorders"
10:35 am - 10:45 am
Discussion
10:45 am - 11:15 am
Coffee Break
11:15 am - 11:35 am
"Exocytosis of Mitochondria"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Metabolic Adaptation of Breast Tumours via Transcriptional Regulation of Mitochondrial Biogenesis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Mitochondrial Augmentation of Hematopoietic Stem Cells in Mitochondrial Deletion Syndromes: From Preclinical Studies to First in Man Trials"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Disease Originated from or Progressed by Mitochondrial Pathobiology
This session will highlight the use of new technologies and approaches to study mitochondrial biology.
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"MICOS Complex Plays a Role in both Biological Aging and PD"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Degradation and Proliferation Are Outcomes of Distinct Types of Mitochondrial Division"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Phosphatidylethanolamine Made in the Inner Mitochondrial Membrane Is Essential for Yeast Cytochrome bc1 Complex Function"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure