Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Mitochondrial Response to Stress in Different Cellular Contexts
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:15 pm
"Electron Transport Chain Heterogeneity Determines Cell Fate Decisions"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Unexpected Outcomes of Mitochondrial Stress Responses"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Molecular Mechanisms Purifying mtDNA"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondria at the Heart of the Matter
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Mitochondria at The Heart of miRNA Processing"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"The Role of LonP1 in Diabetes-Induced Cardiac Dysfunction: Insights into Mitochondrial Proteostasis and Metabolic Adaptation"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Telomere-Mitochondria Homeostasis in Cardiovascular Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"NRF2: Bridging Redox State and Intermediary Metabolism in Cardiac Remodelling"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Mitohormesis in the Heart: Mitochondrial Oxidative Stress Preconditioning Enhances Mitochondrial and Antioxidant Responses via Metabolite Signaling"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Mitochondria Possess a Large, Non-Selective Ionic Current that is Enhanced during Cardiac Injury"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Discovery of an Integrated Signaling System Regulating Ca2+ -Dependent Mitochondrial Metabolons"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitochondria in Environmental Health
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Neurotoxicity of Mitotoxic Stressors Varies Depending on Mechanism of Toxicity"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"In Vitro Modeling Reveals Differential Responses of Neurons and Microglia to Particulate Matter"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Mitochondrial Dysfunction in Repetitive mTBI-Mediated Demyelination"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Inflammation and Impaired Anti-Bacterial Responses in Mitochondrial Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
(Un)conventional Mitochondrial Signaling
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Understanding the Role of Compartmentalized Glutathione Metabolism in Health and Disease"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Examining the Effects of Novel Small Molecule Activators of the Mitochondrial Protease ClpP on Triple Negative Breast Cancer Cells"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Mitochondrial Signaling Platforms at the Outer and Inner Membrane Regulated by Ubiquitin"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"A Novel Lysosome to Mitochondria Signaling Pathway, its Mechanisms and Role in Alzheimer's Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Brown Adipose Tissue Neutrophils Capture Mitochondria from Adipocytes to Maintain Metabolic Homeostasis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Characterization of Mutations in the Nuclear-Encoded RNASEH1 Reveal Significant Loss of Mitochondrial Genome Integrity and Innate Immune Activation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Immunometabolism at the Crossroad Between Inflammation and Aging"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Maintaining Mitochondrial DNA Integrity and Function
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Mitochondrial DNA Repair Defects in the Brain"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Dynamics of Mitochondrial Membranes and Genome Coordinately Protect Against Mitochondrial Dysfunction"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Complicated Relationship of the DNA Polymerases Gamma and Beta"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Regulating Mitochondrial DNA Dynamics by TFAM Acetylation and Phosphorylation"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Lost in (Mitochondrial) Translation
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Mitochondrial mRNA Folding and Translation Regulation"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Mitochondrial RNA Processing: To Cut or Not to Cut?"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"The Importance of Membrane Integration for Translation by the Mitochondrial Ribosome"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Mitochondrial Gene Expression"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Mitochondrial Phosphate Carrier-Dependence of Mitochondrial Calcium and Respiration in Skeletal Muscle"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Nomlabofusp, a Fusion Protein of Human Frataxin and a Cell Penetrant Peptide, Delivers Mature and Functional Frataxin into Mitochondria"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Metabolite-Driven Regulation of Mitochondrial Translation: The Role of Microproteins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mitochondria and AI: What We Can Learn From New Computational Approaches
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Functional Genomics of Mitochondria: Data-Driven Prediction of Mitochondrial Markers and Signaling Pathways"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Enabling the Structural Analysis of Mitochondria and Their Interactions by AI"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Unraveling the Working Mechanism of a Tumor Suppressor Lipid"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Quantitative Subcellular Reconstruction and Volumetric Analyses of Inter-Organelle Networks"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Unresolved Questions in Mitochondrial Biology
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Structural and Functional Heterogeneity of the Human Respiratory Chain"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"The Mitochondrial Nucleoid and mtDNA Copy Number - Roles in Pathology"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
"mPTP, ATP Synthesis and the Spatio-Temporal Dynamics of ATP Synthase"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"How Mitochondrial Proteins Shape The Extramitochondrial Proteome: A Novel Concept of Aging?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Development of Cortical Organoids to Study Mitochondrial Disorders"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Mitochondria in Brain Ischemia Reperfusion, Beyond Energy and ROS"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Primary Cilia and Mitochondrial Function: an Unexpected Liason in Response to Nutrient Availability"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Practical Applications of Mitochondrial Biology
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Omaveloxolone: Pathway to Pharmacological Success In Friedreich Ataxia"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Advances Towards Preventing Transmission of Mitochondrial DNA Disease"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Efficacy of the Small Molecule SBT-589 in a Mouse Model of Leigh Syndrome"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Investigation of mtDNA Diseases in Human-Derived Models to Test Therapies"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure