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Molecular and Cellular Biology of Lipids (GRS)

Gordon Research Seminar

Re-Envisioning the Fluid Mosaic Model of Membrane-Lipid Interactions using Next-Generation Technologies

July 26 - 27, 2025

Chairs

and

Waterville Valley

56 Packard's Road

Waterville Valley, New Hampshire, United States

Venue and Travel Information

Conference Description

The Molecular and Cellular Biology of Lipids GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The Molecular and Cellular Biology of Lipids (MCBL) GRS is an adjunct to the MCBL Gordon Research Conference (GRC). The 2025 MCBL continues to be the premier meeting in the lipid research field, providing a forum for networking, collaboration, and the dissemination of new, predominantly unpublished research findings and breakthrough analytical tools in lipid biology, biochemistry, and biophysics. The 2025 MCBL GRS/GRC will place a particular focus on “Re-Envisioning the Fluid Mosaic Model of Membrane-Lipid Interactions with Next-Generation Technologies.” The fluid mosaic model revolutionized our understanding of membrane-lipid interactions when it was proposed about 50 years ago. While the fundamental structure proposed by this model remains valid, re-envisioning the model in light of the wealth of knowledge made possible by new analytical tools is essential to advance our understanding of the role of membrane lipids in cellular function. The GRS features talks exclusively from graduate students and postdoctoral trainees, providing them an unparalleled opportunity to present their research, gather feedback, and form organic relationships with peers.

Related Meeting

This GRS will be held in conjunction with the "Molecular and Cellular Biology of Lipids" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Lipid Homeostasis Discussion Leader:
3:45 pm - 4:10 pm	"Cracking the SAM Code:The Impact of Methylation on Lipids and Membrane Stress"
4:10 pm - 4:15 pm	Discussion
4:15 pm - 4:25 pm	"Cholesterol-Responsive Interaction of NFE2L1-INSIG1 is Critical for VLDL Biogenesis, Lipid Homeostasis and Liver Health"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lipid Metabolism and Lipid-Driven Disease Discussion Leader:
7:30 pm - 7:40 pm	"Understanding Lipid Dynamics Using Chemical Imaging"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"Armoring T Cell Membranes to Potentiate Anti-Tumor Activity"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"A Spastic Paraplegia-Related DDHD2 Functions as a Lipase and Transacylase that can Remodel the Acyl-Chains of Triglycerides"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Lamin B Receptor Upregulation in Metastatic Melanoma Causes Cholesterol-Mediated Nuclear Envelope Fragility"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Probing the Role of DAG in Cell Membranes and Disease"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Loss of STARD4 Delays Foam Cell Formation by Reducing Free Cholesterol Influx During Digestive Exophagy of Aggregated LDL"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Cardiolipin Regulates Retinoic Acid Metabolism and Signaling: Implications for Barth Syndrome"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"TAFAZZIN-Deficiency Alters Fatty Acid Oxidation"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Membrane Contact and Lipid Remodeling Discussion Leader:
9:00 am - 9:10 am	"ER-Vacuole/Lysosome Tether Mdm1 is Required for Efficient Autophagy"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Phospholipid Biosynthesis Modulates Nucleotide Metabolism and Reductive Capacity"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Regulation of Plasma Membrane Lipid Asymmetry in Candida Albicans"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Regulation of Golgi Phosphoinositides and Protein Trafficking by the Lipid Flippase Neo1"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Temporal Oscillation of Phospholipids During Cell Division"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Study of Serum Albumin Complexation with Bioactive Lipids"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"The Hidden Role of Brain Bile Acids: Microglia Drive Neurodevelopment via Cyp27a1"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Time Travel with Lipid Transfer Proteins: from Nanoseconds to Billions of Years"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: What I Wish I Knew: Insights from PIs on their Toughest Challenges and Valuable Advice Discussion Leader:
1:30 pm - 2:30 pm	Panel Discussion What I Wish I Knew: Insights from PIs on their Toughest Challenges and Valuable Advice
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Institutes of Health under Award Number 1R13HL179935-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Molecular and Cellular Biology of Lipids

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