Sunday, July 4
7:30 PM - 8:30 PM |
Keynote Address |
- Joan Massague (Memorial Sloan-Kettering Cancer Center, NY)
The TGF-b/SMAD pathway
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Monday, July 5
9:00 AM - 12:00 AM |
Signal Transduction I |
Discussion Leader: Ben Neel (Beth Israel Deaconess Medical Center, MA)
- Dafna Bar-Sagi (State University of New York, NY)
Ras signaling and growth control
- Larry Feig (Tufts University School of Medicine)
Downstream signaling from Ras through the Ral GTPase
- 10:30 AM - Coffee Break
- Lew Cantley (Beth Israel Deaconess Medical Center, MA)
Role of P13K in cell growth and cell survival
- Nick Tonks (Cold Spring Harbor Laboratory, NY)
Signaling by tyrosine phosphatases
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Monday, July 5
7:30 PM - 10:00 PM |
Signal Transduction II |
Discussion Leader: Melanie Cobb (University of Texas Southwestern Medical Center, TX)
- Melanie Cobb (University of Texas Southwestern Medical Center, TX)
Structure and regulation of MAP kinase pathways
- John Blenis (Harvard Medical School, MA)
ERK/RSK and p70-S6 kinase signaling during cell growth and death
- Andrey Shaw (Washington University School of Medicine, MO)
Adhesion and T Cell activation
- Gerard Evan (Imperial Cancer Research Fund, UK)
Apoptosis in cancer
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Tuesday, July 6
9:00 AM - 12:00 AM |
Transcription |
Discussion Leader: Doug Dean (Washington University School of Medicine, MO)
- Doug Dean (Washington University School of Medicine, MO)
Transcriptional repression by the retinoblastoma protein
- Jacqueline Lees (Massachusetts Institute of Technology)
Role of E2F in cellular proliferation
- 10:30 AM - Coffee Break
- Don Ayer (University of Utah)
Transcriptional Repression and Activation by the LEF/TCF Family
- Helen Piwnica-Worms (Washington University School of Medicine, MO)
Mitosis: to be or not to be
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Tuesday, July 6
7:30 PM - 10:00 PM |
Cell Cycle Regulation |
Discussion Leader: Chuck Sherr (St. Jude Children's Research Hospital, TN)
- Chuck Sherr (St. Jude Children's Research Hospital, TN)
The ARF-p53 pathway
- Erich Nigg (Univ. of Geneva, Switzerland)
Regulation of the centrosome cycle
- Joan Ruderman (Harvard Medical School, MA)
p27-inducible proteolysis of cell cycle regulators
- James Maller (University of Colorado School of Medicine)
Centrosomes and cell cycle control in early Xenopus embryos
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Wednesday, July 7
9:00 AM - 12:00 AM |
Checkpoints and Cancer |
Discussion Leader: Doug Hanahan (University of California at San Francisco, CA)
- Doug Hanahan (University of California at San Francisco, CA)
Pathways of tumorigenesis
- Gigi Lozano (MD Anderson Cancer Center, TX)
The p53/mdm2 regulatory pathway
- 10:30 AM - Coffee Break
- Ron DePinho(Dana Farber Cancer Institute, MA)
Telomerase, tumor suppressors and tumorigenesis in the mouse
- Tony Wynshaw-Boris (NIH)
Understanding the pleiotropic functions of ATM in vivo by modeling in the mouse
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Wednesday, July 7
7:30 PM - 10:00 PM |
Extracellular Matrix in Signaling |
Discussion Leader: Zena Werb (University of California at San Francisco, CA)
- Zena Werb (University of California at San Francisco, CA)
A matter of choice: multiple signaling pathways downstream from integrins
- Charles Streuli (University of Manchester, UK)
Modulation of differentiation and survival signaling pathways by extracellular matrix
- Sheila Thomas (Beth Israel Deaconess Medical Center, MA)
Cytoskeletal targets of Src PTKs
- Mary Beckerle (University of Utah, UT)
Signaling functions of LIM proteins at sites of cell adhesion
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Thursday, July 8
9:00 AM - 12:00 AM |
Cell Signaling in Development |
Discussion Leader: Barry Gumbiner (Memorial Sloan-Kettering Cancer Center, NY)
- Barry Gumbiner (Memorial Sloan-Kettering Cancer Center, NY)
Signaling by cadherins and catenins
- Doug Hilton (Walter and Eliza Hall Institute for Medical Research, Australia)
SOCS protein negative regulators of cytokine signal transduction
- 10:30 AM - Coffee Break
- Scott Ogg (Massachusetts General Hospital, MA)
Genetic analysis of insulin-like signaling in C. elegans
- Edward Skolnik (New York University Medical Center)
The Ste20 kinase misshapen regulates JNK activation, dorsal closure, and targeting of photoreceptor axons in Drosophila
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Thursday, July 8
7:30 PM - 10:00 PM |
Cell Signaling in Apoptosis |
Discussion Leader: Stan Korsmeyer (Dana Farber Cancer Institute, MA)
- Stan Korsmeyer (Dana Farber Cancer Institute, MA)
When Good Things Happen to BAD and Bad Things to Good Proteins
- Sally Kornbluth (Duke Univerity School of Medicine, NC)
Apoptotic regulation in a Xenopus egg cell-free system
- Junying Yuan (Harvard Medical School )
The proteases to die for
- Ben Neel (Beth Isreal Deaconess Medical Center, MA)
"Signaling by protein-tyrosine phosphatases"
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