Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Origin of Life, Evolution
and Aging
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:30 pm
"Evolutionary Transitions
in the First 1,000,000,000 Years of Life: Emergence of Homochirality and the Genetic
Code"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Evolution and the Origins of Aging"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Setting Evolutionary Rates: Mutation and Recombination
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"How Much Recombination Is Enough?"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Biased Gene Conversion: The Dark Side of Recombination"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Causes and Consequences of the Evolution
of Meiosis and Recombination"
10:55 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Fluctuations and Control of Macromolecules in Bacteria"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Mutation Dynamics and Fitness Effects Followed in Single Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"The Landscape of Replication-Associated Mutations in Human and Mouse Germlines"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Even Parasites Have Parasites: Oscillatory Population Dynamics of Mobile Genetic Elements in Your Genome"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Stress-Inducible Genetic Variation and Evolution
7:30 pm - 7:50 pm
"Real Time Transposable Element Activity
in Live Cells"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Non-Linearity Between Inputs and Outputs
in Stress-Induced Mutagenesis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Eukaryotic Mechanisms of Overcoming Antimicrobial Drug
Stress"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Tumor Evolution by
APOBEC-Catalyzed DNA Deamination"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Genetic Variation and Inheritance
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"On the Role of Mistranslation in Adaptive
Evolution"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Transcription Fidelity
Impedes DNA Break Repair"
10:05 am - 10:15 am
Discussion
10:15 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"Non-Genetic Inheritance and the Evolution of Cooperation"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
"The Role of Epigenetic Mechanisms in the Adaptive Evolution"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Molecular Analysis of Bistability in a Eukaryotic Transcriptional Network"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"A New Theory on the Cause of Genetic Dominance"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Effective Polyploidy Causes Phenotypic Delay and Influences Bacterial Evolvability"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Phenotypic Noise and Evolution
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"An Evolutionary
Perspective on Phenotypic Heterogeneity in Microbes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Adaptations for Harnessing 'Noise'
to Control Fate Specification"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Influenza Evolution Is Modulated by Host Proteostasis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"One Day in the Life, Development and Evolution of a One-Dimensional Organism"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Growth, Differentiation and Self-Organization of S. cerevisiae Colonies in Controlled Spatially Structured Dynamically Changing Environments"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Sibling Paradox: Rapid Evolution
of Genetic Systems for Phenotypic Control by New Genes"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Promiscuity, Serendipity and Metabolic Innovation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Phenotypic Effects of Random Mutation"
11:00 am - 11:10 am
Discussion
11:10 am - 11:20 am
"Random Sequences Rapidly Evolve into De Novo Promoters"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Variation and Novelty in Evolution: De Novo Genes Arise and Enable Protein Structural Innovation"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Proteatoxic Stress Due to Loss of Interaction Partners Induces Reproductive Isolation in Yeast Hybrids"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Repurposing the Function of a Meiotic Cohesin Protein in Budding Yeast"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Evolving Complex Body Plans Through Cell Type Diversity: Molecular and Cellular Mechanisms"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Conditionally
Functional Variation and the Evolution of Complex Traits"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"Ancient Mechanisms for the Evolution of a New Molecular Signaling System"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Alternative Evolutionary Histories in the Sequence Space of an Ancient Protein"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Somatic Evolution: Cancer
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Dissecting Cancer
Evolution: Patterns,
Dynamics and Clinical
Implications"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Error-Prone DNA Polymerases in Melanoma Progression
and Drug Resistance"
9:55 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"E. coli Identifies New Cancer
Gene Functions that Promote Evolvability"
10:55 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Regenerable Altruism in Clonal Cancer Cells"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"High Copy Number of SPATA31 Genes Correlates with Somatic Mutation Rate and Shorter Life Span in Humans"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Intercellular Competition and the Inevitability of Multicellular Aging"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Novel Roles for Retrogenes in Host Immunity"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Extracellular Stimuli Dynamics Can Undermine Optimal Cell Response: Detrimental Misperception by the MAPK Signaling Network in Yeast"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Replaying
the Tape of Life: Experimental Evolution and Evolutionary Contingency
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Long-Term Molecular
Fate of Mutator Genomes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Gene Interactions Cause Repeatable Changes
in E. coli Evolvability"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
"The Dynamics of Molecular Evolution over 60,000 Generations"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Understanding Adaptation and Fitness Trade-Offs in Yeast"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure