Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: From Microbes to Mammals
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
"How and Why Yeast Hedges Its Metabolic Bets"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Discovering the Genomic and Evolutionary Basis of Cellular Robustness Using Common Garden Comparisons of 13 Mammals"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"JUMP, FLIP, HIDE: Rapid, Structural Adaptation in Microbial Genomes"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Genomic Context and Collateral Consequences of Segmental Amplification in Escherichia coli "
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Transposon-Mediated Evolution of Human Immune Gene Regulation"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"Experimental Horizontal Transfer of Phage-Derived Genes to Drosophila Confers Innate Immunity to Parasitoids"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Intragenomic Conflicts in Drosophila: Satellite DNA Evolution and Meiotic Drive"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Pleiotropic Fitness Effects of Large Copy Number Amplifications and Individual Affected Genes Across Environments and Genetic Backgrounds in Candida albicans "
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"The Origin and Mechanism of RNA-Guided Complex Genome Rearrangements in the Ciliate Oxytricha "
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Evolution in a Changing World
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Evolution in a Changing Ocean: Variation in Coral Resistance to Heat Waves and Its Evolutionary and Conservation Potential"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Evolutionary Explanations and Elixirs for PFAS Persistence"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
"Illuminating Hsp90’s Selection Shadow"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Evolution of Eukaryotic-Like Translation Regulation in Giant DNA Viruses"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"A Natural Genotype-Proteome Atlas Reveals the Molecular Basis of Adaptation"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolutionary Sculpting of Protein Sequence, Structure and Function
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Synonymous Codon Substitutions Impact Protein Homeostasis via Diverse Mechanisms"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Protein Fold Evolution Simulation with All-Atom Models"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Stumbling Upon the Ancestral Form of Phosphofructokinase"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Systematic Genetic Characterization of the Human PKR Kinase Domain Highlights Its Functional Malleability to Escape Viral Pseudosubstrate Mimics"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"How Do Proteins Expand Functionality?"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Massively Parallel Interrogation of the Fitness of Natural Variants in Ancient Signaling Pathways Reveals Both Purifying Selection and Local Adaptation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Predicting Antibiotic Resistance"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Discovery of Cellular Dither Pathways"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Tmn: Bacterial Anti-Phage Defense System"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Evolutionary Control of Intestinal Fluid Secretion"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Getting Under Your Skin: Host-Pathogen Conflicts at Epidermal Barriers"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution of Non-Coding DNA
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"From Non-Coding to Coding: the De Novo Emerging Proteome"
9:30 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Coevolution of Promoters, Proteins and Paralogs Facilitates Evolutionary Drift Amidst Constraint in the Genetic Architecture of an Essential Metabolic Step"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Proteins Came in from the Cold: Novel Antifreeze Gene Evolution in Icy Polar Oceans"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"How Does Evolution Build a Brain? Lessons from Genetic Building Blocks"
11:05 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Gene Regulatory Networks and Key Transcription Factors in the Expression of Evolutionarily Young Genes"
11:30 am - 11:40 am
Discussion
11:40 am - 11:50 am
"New Genes Enable Protein Structural Innovation and Function in the Brain"
11:50 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Studying Long Noncoding RNAs Through the Lens of Comparative Genomics"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Beyond Individual Molecules - Evolution in Complex Systems
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Transcription Factors Shape the Mutational Landscape of Regulatory DNA"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:20 pm
"Beyond the Effects of Mutation on Individual Molecules: The Genotype-Phenotype-Phenotype-Phenotype Map"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Eco-Evolutionary Dynamics of Biofilm"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"An Interplay Between the Phenotypic and Genetic Mutations During Evolution"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Genetic Background Sets the Trajectory of Cancer Evolution"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Pre-existing Non-genetic Cellular States Determine Susceptibility to Oncogenic Transformation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"The Diversity of Antifungal Drug Responses"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"The Genetic Basis for Changes in Viral Receptor-Binding Specificities"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Interpreting Viral Evolution"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Blocks to Infection of Human Cells by Divergent Primate Lentiviruses"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Elucidating the Biophysical Constraints on Germline Gene Usage in Broadly Neutralizing Antibodies"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Short Talk Selected from Poster Abstracts
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Genetic Determinants of Evolutionary Fates
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
"Gigantic Introns in Hybrid Incompatibility"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
"Genetic Conflicts During Meiosis Drive the Rapid Evolution of Essential Chromatin Proteins"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure