| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | EXIT FROM THE ER IN HEALTH AND DISEASE |
| Discussion Leader: Charlie Barlowe (Dartmouth University) |
| 7:40 pm - 8:00 pm | Randy Schekman (University of California at Berkeley) "A neural tube closure defect resulting from a lesion in ER export" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Ben Glick (University of Chicago) "Sec16 regulates ER export and transitional ER dynamics" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 8:50 pm | Elizabeth Miller (Columbia University) "A novel Sec24 mutant links cargo capture to the GTP cycle of the COPII coat" |
| 8:50 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:15 pm | Bill Balch (The Scripps Research Institute) "Managing traffic from the ER" |
| 9:15 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | TRANSLOCATION AND PROTEIN FOLDING IN THE ER |
| Discussion Leader: Tom Rapoport (Harvard Medical School) |
| 9:00 am - 9:20 am | Ramanujan Hegde (NIH/NICHD) "Tail-anchored membrane protein insertion into the ER" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Ineke Braakman (University of Utrecht) "Factors determining protein folding in the ER" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Jonathan Weissman (University of California at San Francisco) "The anatomy of a cellular folding compartment: a high resolution view of protein folding in the ER provided by quantitative genetic interaction maps" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Karin Reinisch (Yale University) "Insights into MHC class I peptide loading from the structure of the tapasin/ERp57 heterodimer" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:40 am | Carolyn Sevier (MIT) "Linking ER redox status and ER translocation activity" |
| 11:40 am - 11:45 am | Discussion |
| 11:45 am - 11:55 am | Shu-ou Shan (Caltech) "Fidelity in co-translational protein targeting: binding, induced fit, and kinetic proofreading" |
| 11:55 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Benoit Kornmann (University of California at San Francisco) "The molecular hug between the ER and the mitochondria" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NEW SYSTEMS AND TECHNOLOGIES FOR MEMBRANE BIOLOGY |
| Discussion Leader: Elizabeth Conibear (University of British Columbia) |
| 7:30 pm - 7:50 pm | Christian Eggeling (MPI Biophysical Chemistry, Goettingen) "Fluorescence STED microscopy reveals nanoscale dynamics of membrane molecules" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Lucas Pelkmans (ETH Zurich) "Regulation of membrane lipid composition and function in cell populations: it all depends on the context" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Maya Schuldiner (Weizmann Institute) "Genetics with a twist - novel methods for characterizing proteins required for folding in the secretory pathway" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Julie Brill (University of Toronto) "Clathrin adaptors and PI4KII regulate secretory granule biogenesis in the Drosophila salivary gland" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Barth Grant (Rutgers University) "Amp(h)ing up recycling: functional association of RME-1/Ehd and AMPH-1/Amphiphysin in recycling endosome to plasma membrane transport in C. elegans" |
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | LIPID BIOLOGY AND PATHOGENS |
| Discussion Leader: Sean Munro (MRC Laboratory of Molecular Biology) |
| 9:00 am - 9:20 am | Joost Holthuis (University of Utrecht) "A ceramide sensor hiding in a family of sphingomyelin synthases" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sarah Keller (University of Washington) "Critical phenomena and asymmetric lipid membranes" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Kai Simons (MPI-CBG Dresden) "Lipid-protein interactions and rafts" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Sergio Grinstein (University of Toronto) "Determinants of phagosome formation and maturation" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Gisou van der Goot (Global Health Institute, Lausanne) "How anthrax toxin makes its way into cells" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Stefan Höning (University of Cologne) "TIP47 functions in the biogenesis of lipid droplets" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 am - 12:25 pm | Jairaj Acharya (National Cancer Institute) "Ceramide transfer protein: CERT'nly different tales" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SMALL G PROTEINS IN MEMBRANE DYNAMICS |
| Discussion Leader: Anne Spang (Biozentrum, Basel) |
| 7:30 pm - 7:50 pm | David Lambright (UMass Medical School) "Mechanisms of trafficking-regulation by Rab and Arf GTPases" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Suzanne Pfeffer (Stanford University) "GTPases and ATPases in vesicle tethering at the Golgi" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Francis Barr (University of Liverpool) "Every pot has its lid: matching GEFs and GAPs to Rabs" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Peter Novick (University of California at San Diego) "A Rab GAP Cascade defines the boundary between two Rab GTPases on the secretory pathway" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Zheng Zhou (Baylor College of Medicine) "A novel Rab GTPase that plays essential roles in the degradation of apoptotic cells" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MEMBRANE TRAFFIC IN THE GOLGI APPARATUS |
| Discussion Leader: Ben Glick (University of Chicago)
|
| 9:00 am - 9:20 am | Susan Ferro-Novick (University of California at San Diego) "Mechanistic insights into the function of a multimeric Rab guanine nucleotide exchange factor" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Fred Hughson (Princeton University) "A tale of two tethers" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Jennifer Lippincott-Schwartz (NIH/NICHD) "Kinetic and super-resolution analysis of Golgi structure and function" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Graham Warren (University of Vienna) "Golgi biogenesis in a protozoan parasite" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Bruno Antonny (University of Nice) "How ALPS motifs help to organize membrane traffic" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | David Banfield (The Hong Kong University of Science and Technology) "Identification of the sub-unit interactions and sorting signals that mediate COPI-dependent trafficking of yeast SNAREs" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 am - 12:25 pm | Aki Nakano (RIKEN) "Golgi and post-Golgi traffic as revealed by uniquely evolved plant systems" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ORGANELLES AND THE MOTORS THAT MOVE THEM |
| Discussion Leader: Francis Barr (University of
Liverpool) |
| 7:30 pm - 7:50 pm | Anna Akhmanova (University of Rotterdam) "Bicaudal D - a cell-cycle regulated linker between cargo and microtubule motors" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Steven Gross (University of California at Irvine) "Exactly what is it that NudE and Lis1 do?" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Gillian Griffiths (University of Cambridge) "Controlling polarised secretion from lymphocytes" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Sandra Encalada (University of California at San Diego) "Kinesin-1 mediates the axonal transport of Prion Protein containing vesicles" |
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Lois Weisman (University of Michigan) "Secretory vesicle transport in yeast requires the direct binding of myosin V with multiple Rab GTPases" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | MEMBRANE BENDING AND FUSION |
| Discussion Leader: Fred Hughson (Princeton University) |
| 9:00 am - 9:20 am | David Chan (Caltech) "Mitochondrial membrane fusion by a dynamin family protein" |
| 9:20 am - 9:30 am | Discussion |
| 9:30 am - 9:50 am | Sandy Schmid (The Scripps Research Institute) "Dynamin and membrane fission" |
| 9:50 am - 10:00 am | Discussion |
| 10:00 am - 10:20 am | Tom Rapoport (Harvard Medical School) "Formation of the tubular ER network" |
| 10:20 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:20 am | Chris Stroupe (Dartmouth University) "Reconstitution of yeast vacuole fusion: 5 lipids, 4SNAREs, 3 chaperones, 2 nucleotides, and a Rab, all dancing in a ring" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Elizabeth Chen (Johns Hopkins University) "Defining a fusogenic synapse in myoblast fusion" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Ben Nichols (MRC Laboratory of Molecular Biology) "The generation of membrane curvature within caveolae" |
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 am - 12:25 pm | Thomas Wollert (NIDDK/NIH) "Vesicle formation and scission by the ESCRT-III complex" |
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | ENDOSOMES AND AUTOPHAGY |
| Discussion Leader: Gillian Griffiths (University of Cambridge) |
| 7:30 pm - 7:50 pm | Elizabeth Conibear (University of British Columbia) "Global analysis of endosome recycling" |
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Tamotsu Yoshimori (Osaka University) "Mechanistic insight into membrane dynamics in mammalian autophagy" |
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:40 pm | Sharon Tooze (Cancer Research UK LRI) "Trafficking and signalling pathways to autophagy" |
| 8:40 pm - 8:45 pm | Discussion |
| 8:45 pm - 8:55 pm | Christian Ungermann (University of Osnabrück) "Regulation of HOPS complex localization to endosome-vacuole fusion sites by phosphorylation" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:20 pm | Scott Emr (Cornell University) "ESCRTs and the ART of endocytosis" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |