Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Membrane Research and its Impact on Medicine
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:15 pm
"Linking the ER Stress-Sensing Machinery to Peroxisomal Lipid Import"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:00 pm
"Molecular Basis of Inherited Parkinson's Disease"
9:00 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Atomistic Insights into Signal Integration at the Lysosome Membrane"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein Targeting to Organelles and Quality Control
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Protein Import into Peroxisomes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Protein Import into Chloroplasts: the Ancestor and the Signal"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Exploration of a Translocation Process in the Secretion of Leaderless Cargoes"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Translocon Remodeling During Protein Synthesis at the ER"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"When Protein Folding and Assembly Fails: Membrane Protein Quality Control at the ER"
11:15 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Import Mechanism of Peroxisomal Proteins with an N-Terminal Signal Sequence"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Tankyrase-Mediated PARylation of PEX Proteins Impairs Peroxisome Import"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Exploring the Function of the SRP-Independent (SND) Proteins in Membrane Protein Biogenesis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Organelle Communication and Coordination
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Regulation of Mitochondrial Metabolic Flexibility"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"From Muscle to Memory: ER and Long-Distance Calcium Signaling in Neurons"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Molecular Insights into Lysosomal Biogenesis and Stress Response"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Mechanistic Insights into Bulk Lipid Delivery from the Cryo-EM Structure of a Bridge-Like Lipid Transfer Protein Complexed with a Scramblase"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"How a Bridge-Like Lipid Transport Protein Controls Plasma Membrane Fluidity and Breast Cancer Aggressiveness"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Breaking the Technological Limits in Membrane Research
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"The Architecture of Membrane Contact Sites"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Mechanistic Characterization of Membrane Property Sensors"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Massively Paralleled Genome-Wide Optical Pooled Screen of Secretory Organelles and Cargo Receptors"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Towards Reconstituting Transmembrane Communication of Protein Assemblies: A Suspended Planar Membrane System"
10:25 am - 10:30 am
Discussion
10:30 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
"New Enzymes in Hydroxy-Lipid Catabolism"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Cryogenic FIB-SEM for Whole-Cell Membrane Biology Discovery"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Deciphering the Logic of Mammalian Mitochondrially-Localized Translation Through Optogenetically-Controlled Proximity-Specific Ribosome Profiling"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Mechanism of Lipid Droplet Organelle Biogenesis from the Endoplasmatic Reticulum"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Cellular Mechanisms of Lipid Storage and Lipotoxicity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Keep Calmin and Carry on: Examining the ER in Cell Migration"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:05 pm
"Crossing the Ts in Lipid Control: From TMEM to Torsin"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
"Spatial Organization of Lipid Droplet Catabolism in Yeast"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vesicular Trafficking and Secretion
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:25 am
"Sec24 Intrinsically Disordered Domain Tunes COPII Vesicle Morphology"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Structural Biology of Trafficking GTPase Regulators"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Exocyst Functions to Control Exocytic SNARE Complex Assembly and Vesicle Fusion"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"Roles of the Small GTPase Arf1 in Compartmentalization and Trafficking"
11:10 am - 11:20 am
Discussion
11:20 am - 11:35 am
"Two Opposing Membrane Domains Mediate the Fusion of Large Secretory Vesicles"
11:35 am - 11:45 am
Discussion
11:45 am - 12:00 pm
"The Mechanism of ESCRT-Mediated Membrane Fission Revealed by Archeal Proteins"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Poster Previews
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"How the CO2 -Fixing Pyrenoid gets its Membranes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Revealing Mechanisms of Lipid Homeostasis Using Membrane Editing and Proximity Proteomics"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"The Regulated Architecture of the Membrane of an Animal Cell: An ATP Fueled Fabric"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Alterations in Lipid Saturation Trigger Remodeling of the Outer Mitochondrial Membrane"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"ER Fusogens Maintain Membrane Reservoir to Ensure Brain Function"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Organelle Division, Inheritance and Shaping
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:20 am
"The Convolutated Nature of Interorganelle Lipid Fluxes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Architecture of Synapses Revealed by Cryo-Electron Tomography"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Receptor Endocytosis in the Axon Initial Segment Maintains Neuronal Polarity"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"The Quality Control Mechanism of Lipid Droplet Biogenesis"
10:10 am - 10:15 am
Discussion
10:15 am - 10:50 am
Coffee Break
10:50 am - 11:00 am
"The Mechanism of SMAD Inactivation at the Nuclear Envelope"
11:00 am - 11:05 am
Discussion
11:05 am - 11:15 am
"Regulation of Axonal Trafficking by ER-SV and DCV Membrane Contact Sites in Developing Neurons"
11:15 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Specializations of the Neuronal ER and Intercellular Communication"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Organellar Contact Sites in Axons as Hubs of Mitophagy"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"A Phosphoinositide, a Pentamer and a Prediction: How Yeast Provide Insights into a Neurodegenerative Disease"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Turnover and Repair
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"Stress, Rupture and Repair: Cellular Responses to Endolysosomal Damage"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Mechanisms of Cargo Selection and Autophagosome Biogenesis in Selective Autophagy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Bending but not Breaking: Mechanisms of Lysosome Resilience Under Pressure"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Golgi-Related Ubiquitylation Induced by the STING Pathway"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
"Ultrastructural Visualization of Macroautophagy"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure