| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | GPCR-I |
| Session chair: Michel Bouvier (Université de Montréal, Canada) |
| 7:30-7:40 | Introduction |
| 7:40-8:05 | Jennifer Whistler (University of California, San Francisco)
"RAVE and opiate receptors" |
| 8:05-8:15 | Discussion |
| 8:15-8:40 | Jean Philippe Pin (CNRS, Montpellier, France)
"The activation process of family 3 GPCRs: on the advantage to be two" |
| 8:40-8:50 | Discussion |
| 8:50-9:15 | Stefano Marullo (Institut Cochin, France)
"Additional functions for β-arrestins: concentration of GPCR into constitutive coated pits and nucleocytoplasmic shuttling" |
| 9:15-9:25 | Discussion |
| 9:30 | Welcome reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 | Group Photo |
| 9:00 am - 12:30 pm | GPCR-II |
| Session chair: Bruce Conklin (University of California, San Francisco, Gladstone Institutes) |
| 9:00-9:10 | Welcome from the Conference Chair |
| 9:10-9:20 | Introduction |
| 9:20-9:45 | David Haussler (University of California, Santa Cruz)
"Exploring the human and mouse genomes" |
| 9:45-9:55 | Discussion |
| 9:55-10:20 | Bruce Conklin (University of California, San Francisco, Gladstone Institutes)
"Exploring Hormonal Responses In Vivo with Engineered Receptors, Gene Expression and GenMAPP" |
| 10:20-10:40 | Discussion |
| 10:40-11:10 | Coffee break |
| 11:10-11:35 | Olivier Civelli (University of California, Irvine)
"Orphan GPCR" |
| 11:35-11:45 | Discussion |
| 11:45-12:00 | Mark Akeson (University of California, Santa Cruz)
"Comparative genomics of mouse and human G protein-coupled receptors"
|
| 12:00-12:15 | Olivier Lichtarge (Baylor College of Medicine)
"Signaling determinants reveal functional subdomains in the transmembrane region of G protein-coupled receptors".
|
| 12:15-12:30 | Birgitte Pernille Søndergaard (Institute of Pharmacology, Copenhagen)
"Library of 7TM receptor tails for studies of scaffolding/adaptor protein interactions"
|
| 12:30 pm | Lunch |
| 4:00-6:00 | Poster session 1 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROPAGATING SIGNALS |
| Session chair: Heidi Hamm (Vanderbilt University) |
| 7:30-7:40 | Introduction |
| 7:40-8:05 | Rama Ranganathan (University of Texas, Southwestern)
"Information flow in protein molecules" |
| 8:05-8:15 | Discussion |
| 8:15-8:40 | Elliott Ross (University of Texas, Southwestern)
"Regulating the timing of signal propagation" |
| 8:40-8:50 | Discussion |
| 8:50-9:15 | Julia White (Glaxo-Smith Kline-Europe)
"The heterodimeric GABAB receptor and associated proteins for signaling" |
| 9:15-9:25 | Discussion |
| 9:30 | Mixer and Posters |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ASSEMBLING SIGNALING NETWORKS |
| Session chair: Gil Sambrano (University of California, San Francisco) |
| 9:00-9:10 | Introduction |
| 9:10-9:35 | Heidi Hamm (Vanderbilt University)
"Dissecting networks of G protein signaling pathways" |
| 9:35-9:45 | Discussion |
| 9:45-10:10 | James Ferrell (Stanford University)
"Building a biochemical oscillator: new lessons from Cdc2" |
| 10:10-10:20 | Discussion |
| 10:20-10:50 | Coffee Break |
| 10:50-11:15 | Andre Veillette (McGill University)
"Signaling by adaptors in immune cells" |
| 11:15-11:25 | Discussion |
| 11:25-11:40 | Vladlen Slepak (University of Miami)
"Translocation of G protein, RGS, and arrestin to lipid rafts: mechanisms and effects."
|
| 11:40-11:55 | Terry Hébert (Montreal Heart Institute)
"G Protein-coupled receptor/effector interactions as a mechanism for signaling specificity"
|
| 11:55-12:10 | Stephen Ferguson (University of Western Ontario)
"Protein kinase C isoform-specific differences in the spatial-temporal regulation and decoding of metabotropic glutamate receptor-stimulated second messenger responses"
|
| 12:10-12:30 | Business meeting |
| 12:30 pm | Lunch |
| 4:00-6:00 | Poster session 2 |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SIGNALING CROSS-TALK |
| Session chair: Vladlen Slepak (University of Miami) |
| 7:30-7:40 | Introduction |
| 7:40-8:05 | Louis Luttrell (Duke University)
"Spatial organization of MAP kinase activity by G protein-coupled receptors " |
| 8:05-8:15 | Discussion |
| 8:15-8:40 | Pat Casey (Duke University)
"G12 proteins and cadherins: What's the connection?" |
| 8:40-8:50 | Discussion |
| 8:50-9:15 | Joan Brugge (Harvard University)
"Cell Death Mechanisms in Morphogenesis and Oncogenesis" |
| 9:15-9:25 | Discussion |
| 9:30 | Mixer and posters |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | LOCALIZING THE SIGNAL |
| Session chair: Lee Limbird (Vanderbilt University) |
| 9:00-9:10 | Introduction |
| 9:10-9:35 | Tobias Meyer (Stanford University)
"PIP2 and membrane interactions" |
| 9:35-9:45 | Discussion |
| 9:45-10:10 | Peter Devreotes (Johns Hopkins University)
"How cells sense chemoattractant gradients" |
| 10:10-10:20 | Discussion |
| 10:20-10:50 | Coffee Break |
| 10:50-11:15 | Yoshimi Takai (Osaka University, Japan)
"A mechanism of the localization of signaling molecules by cell adhesion molecules, small G proteins, and ERM" |
| 11:15-11:25 | Discussion |
| 11:25-11:50 | John Condeelis (Albert Einstein College of Medicine)
"Molecular patterns of expression and cell behavior during chemotaxis of carcinoma cells in primary tumors" |
| 11:50-12:00 | Discussion |
| 12:00-12:15 | Michael Tanowitz (University of California San Francisco)
"A link between early endocytic sorting of G protein-coupled receptors and MAP kinase signaling"
|
| 12:15-12:30 | Tatyana Voyno-Yasenetskaya (University of Illinois at Chicago)
"G protein βγ subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: Regulation of cell shape and reactive oxygen species production"
|
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | The 3 Ms: MORPHOLOGY, MIGRATION, AND METASTASIS |
| Session Chair: Joan Heller-Brown (University of California, San Diego) |
| 7:30-7:45 | Introduction |
| 7:45-8:10 | Alan Hall (University College, London)
"Molecular mechanisms controlling cell migration" |
| 8:10-8:20 | Discussion |
| 8:20-8-45 | Linda Van Aelst (Cold Spring Harbor Laboratory)
"Role of regulators of the Rho GTPases in Neuronal Morphogenesis" |
| 8:45-8:55 | Discussion |
| 8:55-9:20 | Henry Bourne (University of California, San Francisco)
"How neutrophils find their way" |
| 9:20-9:30 | Discussion |
| 9:30 | Mixer |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | IN VIVO FUNCTIONS OF 7TMR AND GTPases |
| Session chair: Brian Kobilka (Stanford University) |
| 9:00-9:30 | Introduction
Adrenergic regulation of cardiovascular function |
| 9:30-9:40 | Discussion |
| 9:40-10:05 | Ajamete Kaykas (University of Washington)
"Wnt/Fz pathways: from zebrafish development to human disease" |
| 10:05-10:15 | Discussion |
| 10:15-10:45 | Coffee Break |
| 10:45-11:10 | Stefan Offermanns (University of Heidelberg)
"Biological functions of G-protein mediated signaling - studies in mutant mice" |
| 11:10-11:20 | Discussion |
| 11:20-11:45 | Susan Parkhurst (University of Washington)
"Rho GTPases and Drosophila development" |
| 11:45-11:55 | Discussion |
| 11:55-12:10 | Kirk Druey (National Institutes of Health)
"Role of RGS16 in inflammation-induced T lymphocyte activation and migration"
|
| 12:10-12:25 | Janet Robishaw (Geisinger Clinic)
"Exploring in vivo functions of the G protein βγ subunits"
|
| 12:30 pm | Lunch |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Address |
| 7:30 | Henry Bourne (University of California, San Francisco)
"The G protein story" |
| 9:00 | Mixer |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
