Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structural Basis of GPCR Function
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Structure, Activation and Inhibition of Chemokine Receptors"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:20 pm
"The Role of Protein Dynamics in GPCR Action"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel GPCR Structures and Structure-Based Drug Design
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Structural Mechanisms of Ligand Activation in Class C GPCRs"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"X-Ray Structures of GPCRs Provide Insights into New Binding Sites for Drug Discovery"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"A Structural Understanding of Class B GPCR Activation and G Protein Interaction"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Structure-Based Screens for New Chemotypes Conferring New GPCR Biology"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Structure and Function of Adiponectin Receptors"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Transient GPCR Dimers and Their Functions as Revealed by Single-Molecule Tracking"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
"Oligomeric Architecture of Membrane Receptors"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Breaking into GPCR Structural Space with CryoEM"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Single-Molecule Analysis of Receptor:G Protein Interactions"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Novel Tools and Technologies for GPCR Research
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Towards a
Molecular Understanding of Psychoactive Drug Actions at GPCRs"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"5-HT1A Autoreceptor Control of Serotonin Signaling - Rethinking Modes of
Inhibitory Feedback"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"GPCR Signaling Platforms for Pain and Analgesia"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"RAMPs and Atypical
Chemokine Receptors"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Using Light and Photoregulated Allosteric Ligands for Precise Control of mGluRs Activity In Vivo "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
GPCRs: Signal Compartmentation
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Endosomal and
Mitochondrial GPCR Signaling: Mechanisms and Biological Significance"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
"cAMP: From Long-Range Messenger to Nano-Domain Signalling"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:45 pm
"Compartmentalized cAMP/PKA Signaling in
Living Cells"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Central GPCRs as Drug Targets
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Allosteric Modulators of the Serotonin 5-HT2C
Receptor"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Opioid Receptor Mechanisms Controlling Neurotransmission in Pain Pathways"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Optical Approaches for Dissecting GPCR Signalling in Neural Circuits"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Potential Application of mGlu Modulators
for Treatment of Neurological and Psychiatric Disorders"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"M1-Muscarinic Allosteric Modulators Slow Prion Neurodegeneration and Restore Memory Loss"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Diversity of GPCR Ligands: Clinical Implications
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:35 pm
"Structural and Translational Studies of GPCR Allostery"
6:35 pm - 6:45 pm
Discussion
6:45 pm - 7:10 pm
"Allosteric Modulators of GPCRs for the Treatment
of CNS Disorders"
7:10 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Converting Force into Signal: Metabotropic Mechanosensing Through Adhesion GPCRs"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Exploring the Role of PAR-2 Functional Selectivity for the Development of Anti-Inflammatory Drugs"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
GPCRs
and Metabolism: Clinical Implications
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"GPCRs in
Brown Adipose Tissue"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Autocrine Regulation of Metabolic Functions Through Metabolite GPCRs"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"5-HT2C Receptor:
A Target for Obesity and Type 2 Diabetes Treatment"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Chemogenetic Control of Energy Balance"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Gq-Coupled GPCR Pathways Open New Avenues for the Modulation of Autophagy"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
GPCR Activation and Signaling
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:40 pm
"What Are They Waiting For? - Signaling of GPCRs with Large Ectodomains"
6:40 pm - 6:50 pm
Discussion
6:50 pm - 7:30 pm
"Physiological and Therapeutic Implications of GPCR Functional Selectivity/Biased Signaling"
7:30 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure