Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Pharmacology of GPCR Function in Neurological Disorders
From genetic models to ligands beyond opioids.
7:40 pm - 8:15 pm
"Structural and Spatiotemporal Basis of GPCR Pluridimensional Functional Selectivity"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Reducing Abuse and Aiding Analgesia: Targeting the Dopamine D3 Receptor to Address the Opioid Crisis"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Viral GPCRs Rewire Signaling and Accelerate Glioblastoma Growth"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Structure of a Membrane Adenylyl Cyclase Bound to a G Protein α-Subunit"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Importance of Subcellular Location to Drug Targeting and Signaling
Whether in real estate or in drug targeting, subcellular location is still critical to targeting and signaling.
9:00 am - 9:25 am
"Novel Allosteric Modulators"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Ubiquitin Drives GPCR Inflammatory Signaling"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Disease-Associated Mutation in PTH Unveils Ca2+ Allostery and the Role of Gq in PTH-Receptor Signaling via cAMP"
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
"The Role of Spatial Signaling in GPCR Function"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Compartmentalized Signaling of GPCRs"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Structural Basis for Rapid Desensitization of GPCR Signaling"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"GPCR Signaling in Time and Space"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Biased Signaling
Biased receptors/biased agonism - going in vivo to address functional selectivity, context or just selectivity.
7:30 pm - 7:55 pm
"Single Molecule Analysis of GPCR Coupling in Living Cells"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Biased GPCR Signaling: Progress, Prospects and a Fresh Perspective"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"In Vivo Metabolic Roles of Distinct G Protein- and β-Arrestin-Dependent Signaling Pathways"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"GPCRs: Opening the Gateway to Pathways that Prevent Neurodegeneration"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Screening Complex Mega and Giga Compound Libraries by Docking"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Opiate and Non-Opiate Analgesics
Identifying the issues with classical opiate and non-analgesics and discussing mechanisms and novel therapeutics.
9:00 am - 9:25 am
"Neutral Antagonists at MOR and Opportunities for Treating Neonatal Abstinence Withdrawal Syndromes"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Molecular Pharmacology of CGRP Receptors: Migraine and Beyond"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Tone-Specific Pharmacology: GPCR Allosteric Modulators for Targeting Pain"
10:20 am - 10:25 am
Discussion
10:25 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Mechanisms of CB2 Receptor-Induced Analgesia"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
"NOP/MOP Bifunctional Non-Addicting Analgesics for Opioid Crisis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Structural Bases of μ-Opioid Receptor (MOPr) Activation and Coupling"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Tools for GPCRs as Therapeutic Targets for Neurological Disorders
Novel strategies and progress in drug development for neurological disorders.
7:30 pm - 7:55 pm
"Optical Probing of Neuromodulatory GPCRs"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
"Activation and Allosteric Modulation of Neuroreceptors"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"Photopharmacology of G Protein-Coupled Receptor Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Insights into the Selectivity of Adenosine Receptors"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Atypical GPCRs: Adhesion and Deorphanized GPCR Superfamily Members
Recent developments in figuring out what some of the GPRx family members do.
9:00 am - 9:25 am
"Chemogenetic Approaches to Validate Poorly Characterized GPCRs"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"New Players in Neurological Functions: GPR88"
9:55 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Finding Receptors for Bioactive Molecules"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Force-Dependent Allostery in Cell-Cell Adhesion"
11:10 am - 11:15 am
Discussion
11:15 am - 11:35 am
"Structural and Functional Studies of Adhesion GPCRs and Their Ligands"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Adhesion GPCR-Mediated Cell-Matrix Interaction in Neural Development"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Collagen Regulation of a New GPR56-Directed Signaling Process"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Systems and Proteomics
Recent development in data mining, the implications of drug development, and their influence on complex signaling pathways.
7:30 pm - 7:50 pm
"An Approach for Spatiotemporally Resolving GPCR Protein Interaction Networks Regulating Receptor Signaling"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Genome-Wide Discovery of New Microbial Molecular Probes from Chemical Genetic Interactions"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Illuminating the Dark Corridors of the GPCR-ome"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Regulation of Exocytosis by Inhibitory GPCRs and Gβγ Subunits"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Alternative Splicing of GPCR Signalling Components as a Source of Tissue-Specific Receptor Pharmacology"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
How Form and Function Are Tightly Linked in GPCRs
How structures continue to provide mechanistic insight; high resolution structure determination by x-ray diffraction and cryoEM; how structures finally help drug design; GPCRs as moving pictures: more than telling a thousand words.
9:00 am - 9:25 am
"Multiple Conformations of Photoactivated Rhodopsin: Role in Signal Transduction"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"The Role of GPCR Dynamic in Signaling"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"The Molecular Basis for High-Affinity Agonist Binding at the β1-Adrenoceptor"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Probing Conformational Dynamics by Solution NMR"
10:40 am - 10:45 am
Discussion
10:45 am - 11:10 am
Coffee Break
11:10 am - 11:35 am
"Structural Basis for CXCR Signaling Illuminated by Experimental and Computational Approaches"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Structural and Functional Diversity in Receptor-Arrestin Complexes"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"Structural Insights into Class B GPR Signalling and Allostery"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Innovative Drug Screening and Design Approaches
Computational and novel methodologies and good old fashioned medicinal chemistry - repurposing GPCR drugs for disease: new life as anti-cancer therapeutics.
7:30 pm - 7:50 pm
"DNA-Encoded Libraries for Drug Discovery"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Structure-Based Virtual Ligand Screening and Design for New GPCR Probes"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Structure-Guided Strategies: How to Find Useful GPCR Ligands"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"From Binding to Biophysics: My 50 Years (and Counting) of GPCR Research"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular Mechanisms of Biased Agonism at the Angiotensin Receptor"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure