Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Understanding Ligand Intrinsic Efficacy
7:40 pm - 8:30 pm
"Beta-Arrestin-Coupled Receptors and G Protein-Coupled Receptors: A tale of Two Transducers"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Precise Targeting of GPCR Signaling"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Allostery, Bias and Efficacy: Three Sides of the Same Coin"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Functional Dynamics and Single-Molecule Visualization of Signaling
9:00 am - 9:20 am
"Single-Molecule Imaging Reveals the Dynamics and Activation of G Protein-Coupled Receptors"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"The Influence of Lipids on GPCR Conformational Dynamics"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"How Nanodomains of Quantised GPCR Intrinsic Activation Define Macroscopic Agonist Potency and Efficacy"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Modulation of G protein Dynamics by GPCR Ligands"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Non-Equilibrium Structural Pharmacology of the Mu-Opioid Receptor"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Molecular Mechanisms of Metabotropic Glutamate Receptor/Arrestin Coupling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"The Alpha-helical Domain of Gα, a New Regulator of the Heterotrimeric G Protein Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Ligand-Specific Activation Trajectories Dictate GPCR Signaling in Intact Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
AI-Driven GPCR Analysis and Drug Discovery
7:30 pm - 7:50 pm
"Structure-Based Design of GPCR Ligands Using Artificial Intelligence"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Drug Design with AI Structures"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Deciphering Mechanisms of Allostery, Biased Agonism, G Protein Coupling Selectivity of GPCRs"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Interpretable AI for Uncovering Cooperativity and Allostery in Protein Complexes"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Closing the Generative AI Augmented GPCR Structure-Based Drug Discovery Loop"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Revolutionizing GPCR: Targeted Drug Discovery with Advanced Technologies
9:00 am - 9:20 am
"Targeting Novel G-Protein Coupled Receptors in Neuropsychiatric Disorders"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Single Domain Antibodies and Allosteric Modulators for GPCRs: Discovery and Validation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Uncovering the Action of Unconventional GPCR Stimuli"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"New Families of "Superdark" GPCR-like Proteins in Humans"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Activation of Relaxin Receptor Signaling by Diverse Agonists"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"An Engineered Optogenetic Platform to Activate Sub-Cellular GPCR Signalling"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"The Secret Life of G Proteins"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Discovery of Activating GPCR Antibodies with an AI-Enabled Platform"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bridging GPCR Signaling and Immune Regulation: Emerging Insights and Therapeutic Avenues
7:30 pm - 7:50 pm
"Modulation of Canonical and Atypical Chemokine Receptor Function by Nanobodies"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:15 pm
"Exploiting the GPCR-Chemokine Network to Reprogram the Tumor Microenvironment for Improved Immunotherapy"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Spatial Regulation of GPCR-ERK Signaling"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Ramping Up Protein Complexes for Lymphatic Therapeutics"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"High Binding Plasticity and Ligand Promiscuity of the Atypical Chemokine Receptor ACKR5"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Central Role of GPCRs in Neuroscience and Neuropharmacology
9:00 am - 9:20 am
"Targeting G Protein Signaling Pathways to Disrupt the Maintenance of Chronic Pain"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Brain Disorders and Muscarinics: Light at the End of the Tunnel"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Molecular Mechanisms of Inverse Agonism via K-Opioid Receptor–G Protein Complexes"
10:00 am - 10:05 am
Discussion
10:05 am - 10:35 am
Coffee Break
10:35 am - 10:55 am
"Deciphering the Diverse Mechanisms of Activation in Metabotropic Glutamate Receptor Heterodimers"
10:55 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Neuropeptide Regulation of Mosquito Blood Feeding and Mating"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Interplay Between the Extracellular and Transmembrane Domains of a Holo-Adhesion GPCR"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Interactions Between the Opioid and PACAPergic Systems: Implications for Headache and Pain Management"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Structural and Dynamic Insights into Human κ-Opioid Receptor Signaling"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
GPCRs at the Heart of Metabolism: Unlocking New Avenues for Disease Intervention
7:30 pm - 8:10 pm
"GLP-1 Mechanisms in Diabetes, Obesity, Cardiovascular and Kidney Disease"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Metabolites as Signals in Adipose Tissue and Energy Homeostasis"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"GPCR Biased Signaling Strengthens Endothelial Cell Resilience"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Functional Implications of Biased Signaling at the GLP-1R"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Exploring GPCRs' Impact on Intracellular Signaling Landscapes
9:00 am - 9:20 am
"Subcellular Organization and Reorganization of GPCR Signaling"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"GPCR Signaling: A Spatial Story"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Monoamine Transporters: The Dynamic Modulators of Subcellular GPCR Activity"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Myosin VI Drives Arrestin-Independent Internalization and Signaling of GPCRs"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Signaling and Non-Signaling GPCRs in Type 2 Diabetes and Cardiac Regeneration"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"β-arrestin-Mediated Compartmentalization of Active GPCRs in Membrane Nanodomains via PIP2 Binding"
11:45 am - 11:50 am
Discussion
11:50 am - 12:10 pm
"Regulated Anterograde Transport of Class A GPCRs Uncovered by a Genome-Wide CRISPR Screen and High Content Imaging"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Systematic Mapping of GPCR Signaling Networks: A Proteomic Approach to GRK- and ß-Arrestin-Dependent Interactions"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Expanding Horizons in GPCRs in Health and Disease
7:30 pm - 7:50 pm
"The Open Conformation of Galphas"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Investigating the Molecular Mechanism of GBY-SNARE Mediated Inhibition of Exocytosis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Adhesion GPCRs Regulating Glucose and Energy Homeostasis"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Structural and Pharmacological Insights into Targeting Class B1 GPCRs for Metabolic Disease"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure