| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | OVARIAN CANCER |
| Discussion Leader: Robert Young (Fox Chase Cancer Center) |
| 7:40 pm | Sandra Orsulic (Harvard Medical School)
"Transgenic mouse models for molecular characterization of ovarian cancer" |
| 8:15 pm | Discussion |
| 8:40 pm | Gordon R. Whiteley (NCI Clinical Proteomics Reference Labs)
"Proteomics profiling tools for the diagnosis and treatment of ovarian cancer" |
| 9:15 pm | Discussion |
| MONDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | APOPTOSIS |
| Discussion Leader: Caroline Dive (University of Manchester) |
| 9:10 am | David Vaux (The Walter and Eliza Institute of Medical Research)
"IAPs as therapeutic targets?" |
| 9:45 am | Discussion |
| 10:10 am | Coffee Break |
| 10:30 am | Steve Fesik (Abbott Laboratories)
"Discovery of Bcl-XL inhibitors for the treatment of cancer" |
| 11:05 am | Discussion |
| 11:30 am | Marie Hardwick (Johns Hopkins University)
"Programmed cell death in yeast and neurons" |
| 12:05 pm | Discussion |
| 12:45 pm | Lunch / Photo |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PROTEOMICS / FUNCTIONAL GENOMICS |
| Discussion Leader: Martin Brown (Stanford University) |
| 7:40 pm | Simon Boulton (Cancer Research UK, Clare Hall)
"Functional genomic analysis of the C. elegans DNA damage response" |
| 8:15 pm | Discussion |
| 8:40 pm | Michael Snyder (Yale University)
"Global analysis of genomes and proteomes" |
| 9:15 pm | Discussion |
| TUESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CHAPERONES AND STRESS RESPONSE |
| Discussion Leader: Amato Giaccia (Stanford University) |
| 9:10 am | D. Lynn Kirkpatrick (ProlX Pharmaceuticals)
"PX-47: a potent inhibitor of HIF-1α and antitumor agent" |
| 9:45 am | Discussion |
| 10:10 am | Coffee Break |
| 10:30 am | Luke Whitesell (University of Arizona)
"Heat shock response-guided anticancer drug discovery" |
| 11:05 am | Discussion |
| 11:30 am | Linda Hendershot (St. Jude Children's Research Hospital)
"The mammalian unfolded protein response and its effects on chemosensitivity?" |
| 12:05 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | CELL CYCLE REGULATION |
| Discussion Leader: John Lazo (University of Pittsburgh) |
| 7:40 pm | Charles Sherr (St. Jude Children's Research Hospital)
"The Ink4a-Arf Network" |
| 8:15 pm | Discussion |
| 8:40 pm | Robert Jackson (Cyclacel, Ltd)
"CYC202 (R-roscovitine): clinical and preclinical update on a CDK inhibitor" |
| 9:15 pm | Discussion |
| WEDNESDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | KINASES AND INHIBITORS |
| Discussion Leader: Judith Sebolt-Leopold (Pfizer Global Research and Development) |
| 9:10 am | Steve Averbuch (AstraZeneca)
"Beyond HER2: The Clinical Realities for EGFR and other tyrosine kinases" |
| 9:45 am | Discussion |
| 10:10 am | Coffee Break |
| 10:30 am | Heidi Lane (Novartis Pharma AG)
"The rapamycin derivative RAD001 in oncology: from the laboratory to the patient" |
| 11:05 am | Discussion |
| 11:30 am | Hidenori Ichijo (University of Tokyo)
"Stress responses mediated by the ASK1-SAPK signals" |
| 12:05 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | NUCLEAR ARCHITECTURE ANS CHROMATIN |
| Discussion Leader: Nancy Davidson (Johns Hopkins University) |
| 7:40 pm | Steve Baylin (Johns Hopkins University)
"Reversal of epigenetically mediated gene silencing as a target for cancer prevention and therapy" |
| 8:15 pm | Discussion |
| 8:40 pm | Victoria Richon (Aton Pharma)
"Development of Histone Deacetylase inhibitors" |
| 9:15 pm | Discussion |
| THURSDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | DNA TRANSACTIONS |
| Discussion Leader: Neil Osheroff (Vanderbilt University) |
| 9:10 am | Ian Hickson (University of Oxford)
"Combined actions of RecQ helicases and topo III in suppressing chromosomal instability" |
| 9:45 am | Discussion |
| 10:10 am | Coffee Break |
| 10:30 am | Stewart Shuman (Memorial Sloan-Kettering Cancer Center)
"The case for DNA ligase as a target for antimicrobial and anticancer therapy" |
| 11:05 am | Discussion |
| 11:30 am | Alex Burgin (deCODE Genetics)
"Structural Insights into the Mechanism of Topoisomerase I poisons" |
| 12:05 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Select Poster Presentations |
| 6:00 pm | Reception / Dinner |
| 8:00 pm - 9:00 pm | KEYNOTE ADDRESS |
| 8:00 pm - 9:00 pm | Sir David Lane (University of Dundee)
"Drug discovery in the p53 pathway" |
| FRIDAY |
| 7:45 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
