| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:35 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:35 pm - 9:30 pm | Stem cells in epithelial cancers |
| Discussion Leader: Max Wicha, M.D. (Univ. of Michigan Cancer Center) |
| 7:35 pm - 7:45 pm | Introduction |
| 7:45 pm - 8:10 pm | Max Wicha, M.D. (Univ. of Michigan Cancer Center)
"Molecular Targets in Breast Cancer Stem Cells" |
| 8:10 pm - 8:20 pm | Discussion |
| 8:20 pm - 8:45 pm | Sam Janes, M.D., Ph.D. (University College London)
"Mouse models, stem cells and epithelial cancers; from skin to thymus to lung" |
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Jeremy Rich, M.D. (Duke University Medical Center)
"Cancer Stem Cells in Therapeutic Resistance and as Therapeutic Targets" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Exosomes, tetraspanins, and lipidomics |
| Discussion Leader: Alain Delcayre, Ph.D. (BN- Immuno Therapeutics) |
| 9:00 am - 9:15 am | Introduction |
| 9:15 am - 9:45 am | Alain Delcayre, Ph.D. (BN- Immuno Therapeutics)
"Exosome Technologies for the Development of new Therapeutics" |
| 9:45 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break / Group Photo |
| 10:40 am - 11:10 am | Martin Hemler, M.D. (Dana Farber Cancer Institute)
"Tetraspanins and associated proteins affect tumor progression at multiple levels" |
| 11:10 am - 11:35 am | Discussion |
| 11:35 am - 12:05 pm | Alex Brown (Vanderbilt University Medical Center)
"Electrospray ionization mass spectrometry based lipid profiling: pathways of inflammation" |
| 12:05 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Autophagy, the unfolded protein response and cancer |
| Discussion Leader: Linda Hendershot, Ph.D. (St. Jude Children's Research Hospital) |
| 7:30 pm - 7:45 pm | Introduction |
| 7:45 pm - 8:15 pm | Linda Hendershot, Ph.D. (St. Jude Children's Research Hospital)
"The Unfolded Protein Response: Effects of Chemosensativity of Tumor Cells" |
| 8:15 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:05 pm | Costa Koumenis, Ph.D. (University of Pennsylvania School of Medicine)
"Induction of the UPR by hypoxia: a contributor to tumor aggressiveness and opportunity for therapeutic intervention" |
| 9:05 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Emerging kinase targets |
| Discussion Leader: Robert Kramer, Ph.D. (Bristol Myers Squibb) |
| 9:00 am - 9:15 am | Introduction |
| 9:15 am - 9:45 am | Ravi Salgia, M.D., Ph.D. (Univ. of Chicago Hospitals)
"Therapeutic targeting of c-Met in solid tumors, particular emphasis on lung cancer" |
| 9:45 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break |
| 10:40 am - 11:10 am | Steven Haney, Ph.D. (Wyeth Research)
"RNAi screening of protein kinase genes for new anticancer drug targets" |
| 11:10 am - 11:35 am | Discussion |
| 11:35 am - 12:05 pm | Elizabeth Buck (OSI Pharmaceuticals)
"Interplay Between EGFR-TKI Resistance Mechanisms, EMT Biology and a Rationale for Multi-Targeting" |
| 12:05 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Akt and MTOR |
| Discussion Leader: Mary-Ann Bjornsti, Ph.D. (St. Jude Children's Research Hospital) |
| 7:30 pm - 7:45 pm | Introduction |
| 7:45 pm - 8:15 pm | Nissim Hay, Ph.D. (Univ. of Illinois at Chicago)
"The role of Akt in energy metabolism and the genesis of cancer-implications for cancer therapy" |
| 8:15 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:05 pm | David Sabatini, M.D. (Whitehead Institute)
"Signaling through the mTORC 1 and mTORC 2 Pathways" |
| 9:05 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Repositioning old drugs as cancer therapeutics |
| Discussion Leader: Warren Chow, M.D. (City of Hope National Medical Center / Beckman Research Inst.) |
| 9:00 am - 9:15 am | Introduction |
| 9:15 am - 9:45 am | Warren Chow, M.D. (City of Hope National Medical Center / Beckman Research Inst.)
"Repositioning Old Drugs as Cancer Therapeutics: Nelfinavir" |
| 9:45 am - 10:10 am | Discussion |
| 10:10 am | Coffee Break |
| 10:40 am - 11:10 am | Ping Dou, Ph.D. (Barbara Ann Karmanos Cancer Inst. / Wayne State University)
"New use of old copper-binding drugs: converting the proangiogenic copper to a specific Cancer cell death inducer" |
| 11:10 am - 11:35 am | Discussion |
| 11:35 am - 12:05 pm | Diane Palmieri, M.D. (National Cancer Institute)
"Medroxyprogesterone Acetate elevation of the Nm23-H1 metastasis suppressor - a new use for an old drug" |
| 12:05 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Making the untreatable treatable: lessons from kidney cancer |
| Discussion Leader: Ronald Bukowski, M.D. (CCF Lerner College of Medicine of CWRU) |
| 7:30 pm - 7:45 pm | Introduction |
| 7:45 pm - 8:15 pm | Ronald Bukowski, M.D. (CCF Lerner College of Medicine of CWRU)
"Renal Cell Carcinoma: A New Treatment Paradigm in Advanced Disease" |
| 8:15 pm - 8:35pm | Discussion |
| 8:35 pm - 9:05 pm | Marston Linehan, M.D. (National Cancer Institute)
"Genetic basis of cancer of the kidney: foundation for disease specific therapy" |
| 9:05 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am - 9:00 am | Business Meeting (Part 1) |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms) |
| 9:00 am - 12:30 pm | MicroRNA |
| Discussion Leader: Carlo Croce, M.D. (Ohio State Univ. Cancer Center) |
| 9:00 am - 9:15 am | Introduction |
| 9:15 am - 9:45 am | Carlo Croce, M.D. (Ohio State Univ. Cancer Center)
"microRNA Genes and Human Cancer" |
| 9:45 am - 10:10 am | Discussion |
| 10:10 am - 10:20 am | Business Meeting (Part 2) |
| (Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 10:20 am | Coffee Break |
| 10:40 am - 11:10 am | Curtis Harris, M.D. (National Cancer Institute)
"Inflammation and Cancer: interaction of microRNA, cytokine and p53 pathways" |
| 11:10 am - 11:35 am | Discussion |
| 11:35 am - 12:05 pm | Paul Foster, Ph.D. (Newcastle University)
"Identification of miRNA signatures for the characterization of respiratory diseases: asthma and chronic obstructive pulmonary disease (COPD)" |
| 12:05 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | What have we learned from targeting VEGF? |
| Discussion Leader: Hiliary Calvert, Ph.D. (Newcastle University) |
| 7:30 pm - 7:45 pm | Introduction |
| 7:45 pm - 8:15 pm | Alan Sandler, M.D. (Vanderbilt-Ingram Cancer Center)
"Targeting VEGF - Clinical Applications" |
| 8:15 pm - 8:35 pm | Discussion |
| 8:35 pm - 9:05 pm | Afshin Dowlati, M.D. (Case Western Reserve University)
"Circulating angiogenic and adhesion molecules as potential predictive markers for bevacizumab-based therapy" |
| 9:05 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
