| SUNDAY, JUNE 10, 2001 |
| 2:00- | Arrival & Registration |
| 6:00-7:00 pm | Dinner |
| 7:30-9:00 pm | Welcome and Keynote Lecture |
| RON VALE, UCSF
Creation of Molecular Motors Through Evolution or Design |
| 9:00-midnight | Opening Reception in Ware Campus Center |
| MONDAY, JUNE 11, 2001 |
| 7:30-8:30 am | Breakfast |
| 9:00 am-12:30 pm | I. SIGNALING TO THE CYTOSKELETON |
| 9:00-9:30 am | CAROLE PARENT (CHAIR), NIH
G-protein coupled signaling and directed cell migration |
| 9:30-10:00 | DOUG LAUFFENBERGER, MIT
EGF receptor signaling to biophysical processes in cell migration |
| 10:00-10:30 pm | Conference Photo and Coffee Break |
| 10:30-11:00 | PHILIPPE CHAVRIER, Institut Curie
Function of Rho GTPases in actin dynamics during phagocytosis
|
| 11:00-11:15 | BRITTA EIKHOLT, Kings College, London
GSK-3 inhibition masks a repulsive guidance signal in motile growth cones |
| 11:15-11:30 | ARTHUR ALBERTS, Van Andel Research Institute
Diaphanous-related Formins Bridge Rho GTPases to Arp2/3 |
| 11:30-11:45 | HELEN YIN, University of Texas, Southwestern Medical Center
Phosphoinositide regulation of the actin cytoskeleton |
| 11:45-12:00 | STEVE BUNNELL, NIH
Dynamic actin polymerization drives T-cell receptor-induced spreading: a role for the signal transduction adaptor, LAT |
| 12:30-1:30 pm | Lunch |
| 1:30-4:00 pm | Free Time |
| 4:00-6:00 pm | POSTER SESSION I |
| 6:00-7:00 pm | Dinner |
| 7:30-10:00 pm | II. MOTOR-CARGO INTERACTIONS |
| 7:30-7:45 | VLADIMIR GELFAND (CHAIR), University of Illinois
Introduction |
| 7:45-8:15 | ANTHONY BROWN, Ohio University
Stop and go traffic of cytoskeletal proteins in axons. |
| 8:15-8:45 | GEORGE B. WITMAN, University of Mass Med School
Intraflagellar transport and disease. |
| 8:45-9:00 | JONATHAN BERG, University of North Carolina
Myosin-X is an unconventional myosin that undergoes intrafilopodial motility |
| 9:00-9:15 | MICHAEL WAY, EMBL Heidelberg
Anterograde microtubule-based motility of vaccinia virus |
| 9:15-9:30 | LOIS WEISMAN, University of Iowa
Identification of an organelle-specific myosin V receptor |
| 9:30-9:45 | VLADIMIR GELFAND (CHAIR), University of Illinois
Regulation of myosin-V by cargo binding |
| 9:45-10:00 | KEVIN VAUGHAN, University of Notre Dame
Regulation of Cytoplasmic Dynein's Cargo-Binding Activity Through Dynein IC Phosphorylation |
| 10:00-midnight | Social in the Ware Campus Center |
| TUESDAY, JUNE 12, 2001 |
| 7:30-8:30 am | Breakfast |
| 9:00 - 12:30 pm |
III. REGULATION OF ACTIN ASSEMBLY |
| 9:00-9:25 am | RONG LI (CHAIR), Harvard Medical School
Regulation of actin polymerization by Cdc42 during cell polarization in yeast |
| 9:25-9:45 | JOHN HAMMER, National Institutes of Health
The CARMIL Protein Links Capping Protein and the Arp2/3 Complex to Myosin I |
| 9:45-10:15 | TOM POLLARD, Salk Institute
Nucleation of actin polymerization by the Arp2/3 complex |
| 10:15-10:45 | Coffee Break |
| 10:45-11:00 | DYCHE MULLINS, University California San Francisco
The activity of the Arp2/3 complex is tunable |
| 11:00-11:15 | ALISSA WEAVER Washington University School of Medicine
Role of cortactin in Arp2/3-mediated actin network assembly |
| 11:15-11:30 | WILLIAM BRIEHER, Harvard Medical School
Fractionation for Factors Involved in Listeria Propulsion |
| 11:30-11:45 | VELIA FOWLER, Scripps Institute
Actin pointed end dynamics and tropomodulin capping |
| 11:45-12:00 | AMY MCGOUGH, Purdue University
Structural studies of cofilin-actin complexes |
| 12:30-1:30 pm | Lunch |
| 1:30-4:00 pm | Free Time |
| 4:00-6:00 pm | POSTER SESSION II |
| 6:00-7:00 pm | Dinner |
| 7:30 pm-10:00 pm | IV. CELL MOTILITY |
| 7:30-8:00 | FRANK GERTLER (CHAIR), MIT
Regulation of cell motility by Ena/Vasp proteins |
| 8:00-8:30 | PAUL FORSCHER, Yale University
Molecular dynamics of guided axon growth |
| 8:30-9:00 | MARIE-FRANCE CARLIER, CNRS, Gif sur Yvette, Fra
Arp2/3 complex in actin-based motility |
| 9:00-9:15 | MARGARET TITUS, University of Minnesota
Role of myosin VII in cell adhesion |
| 9:15-9:30 | JOHN CONDEELIS, Einstein College of Medicine
Interactions between cofilin and Arp2/3 complex in vivo in the regulation of leading edge dynamics |
| 9:30-9:45 | TENG-LEONG CHEW, Northwestern University Medical School
A FRET-based biosensor reveals dynamic compartmentalization of myosin light chain kinase activity during cell migration and shape change |
| 9:45-10:00 | DAVID KNECHT, University of Connecticut
Myosin II motor function is not necessary to stabilize the cell cortex during
motility under restrictive conditions |
| 10:00-midnight | Social in the Ware Campus Center |
| |
| WEDNESDAY, JUNE 13, 2001 |
| 7:30-8:30 am | Breakfast |
| 9:00 am-noon | V. MICROTUBULE-CORTICAL INTERACTIONS |
| 9:00-9:15 | GREG GUNDERSEN (CHAIR), Columbia Medical School
Introduction |
| 9:15-9:45 | DAVID PELLMAN, Dana Farber Cancer Institute
Dual function for microtubule end-binding proteins at the membrane and at the kinetochore |
| 9:45-10:15 | TONY BRETSCHER, Cornell University
Myosin V and polarized actin cables in cell growth, organelle segregation and spindle orientation |
| 10:15-10:45 | Coffee Break |
| 10:45-11:00 | GREG GUNDERSEN, Columbia Medical School
Distinct Rho and CDC42 signaling pathways for microtubule polarization in migrating cells |
| 11:00-11:30 | NIELS GALJART, Erasmus University, The Netherlands
CLIPs, CLASPs and microtubule behaviour |
| 11:30-11:45 | LEE LIGON, University of Pennsylvania
Dynein binds to beta-catenin and may tether microtubules at adherens junctions
|
| 11:45-12:00 | CLARE WATERMAN-STORER, Scripps Institute
Interactions of microtubules and actin in migrating newt lung epithelial cells revealed by dual wavelength fluorescent speckle microscopy |
| 12:30-1:30 pm | Lunch |
| 1:30-4:00 pm | Free Time |
| 4:00-6:00 pm | POSTER SESSION III |
| 6:00-7:00 pm | Dinner |
| 7:30-10:00 pm | VI. MEMBRANE DYNAMICS AND THE CYTOSKELETON |
| 7:30-8:00 | MARK McNIVEN (CHAIR), Mayo Clinic
Dynamin and the actin cytoskeleton |
| 8:00-8:30 | PIETRO DE CAMILLI, Yale University
A link between endocytic proteins and actin dynamics |
| 8:30-9:00 | WILLIAM TRIMBLE, Hospital for Sick Children, Toronto
Contribution of targeted exocytosis to phagocytosis and bacterial invasion |
| 9:00-9:15 | ROBERTO BUCCIONE, Consorzio Mario Negri Sud, Italy
Dynamin function and Invadipodia |
| 9:15 - 9:30 | JON KULL, Max Planck Institute, Heidelberg
Crystal structure of the GTPase domain of dynamin |
| 9:30-9:45 | CRISLYN D'SOUZA-SCHOREY, University of Notre Dame
Arf6 regulates adherens junction assembly in epithelial cells |
| 9:45 - 10:00 | SERGEY POPOV, University of Illinois, Chicago
Membrane Delivery to neuronal processes: regulation by axonal microtubules |
| THURSDAY, JUNE 14, 2001 |
| 7:30-8:30 am | Breakfast |
| 9:00 am-noon | VII. CENTROSOMES AND SPINDLE ASSEMBLY |
| 9:00-9:15 | YIXIAN ZHENG (CHAIR), Carnegie Institute
Introduction: Centrosome and spindle, the old disciplines with new twists |
| 9:15-9:45 | MICHELLE BORNENS, Institut Curie, France
The Centrosome: a role in cell division, in cell locomotion or another role? |
| 9:45-10:15 | ALEXEY KHODJAKOV, Wadsworth Center
Consequences of centrosome inactivation |
| 10:15-10:45 | Coffee Break |
| 10:45-11:00 | STEVE DOXSEY, U Mass. Medical School
Pericentrin interacts directly with GCP3 to direct assembly of soluble g-tubulin ring complexes onto centrosomes |
| 11:00-11:15 | FRANK MCNALLY, University of California at Davis
Katanin regulates g-tubulin organization and tubulin turnover in the mitotic spindle |
| 11:15-11:30 | TARUN KAPOOR, Rockfeller University
Comparison of Eg5 and tubulin dynamics in bipolar spindle, evidence for spindle assembly |
| 11:30-11:45 | MARY DASSO, NIH
The Ran GTPase regulates spindle assembly and mitotic progression |
| 11:45-12:00 | CHRIS WIESE, Carnegie Institute
Role of importin beta in spindle assembly |
| 12:30-1:30 pm | Lunch |
| 4:00-6:00 pm | ROUNDTABLE DISCUSSION |
| 6:00-7:00 pm | Dinner |
| 7:30-9:30 pm | VIII. MITOSIS AND CYTOKINESIS |
| 7:30-7:35 | TED SALMON (CHAIR), Univ of North Carolina
Cell division 2001, an introduction |
| 7:35-8:05 | TIM YEN, Fox Chase Cancer Institute
Mammalian kinetochore assembly and function in mitosis. |
| 8:05-8:35 | KERRY BLOOM, University of North Carolina
Chromosome dynamics in yeast |
| 8:35-8:50 | KAREN OEGEMA, Max Planck Institute, Dresden, Germany
Chromosome segregation and kinetochore assembly in the one-cell stage C. elegans embryo |
| 8:50-9:20 | RICHARD VALLEE, University of Massachusetts Med Center
Role of cytolasmic dynein in mitosis and the brain developmental disease lissencephaly |
| 9:20 - 9:35 | CHRISTINE FIELD, Harvard University Medical School
Anillin's role in cleavage furrow formation |
| 9:35 - 9:50 | TATSUHIKO NOGUCHI, University of Tokyo
Actin-myosin at the growing ends of the cleavage furrow in Xenopus eggs |
| 10:00-midnight | Closing Reception in the Ware Campus Center |
| FRIDAY, JUNE 15, 2001 |
| 9:00 am | Buses leave |
