| Saturday |
| 1:30 pm - 4:30 pm | Arrival and Check-in |
| 3:00 pm - 3:15 pm | Introductory Comments by GRC Site Staff / Welcome by the GRS Conference Chair |
| 3:15 pm - 4:00 pm | Keynote Session / In Vivo Pharmacokinetics and Toxicological Effects |
| Discussion Leader: Verena Keitel (University of Dusseldorf, Germany) |
| 3:15 pm - 3:20 pm | Opening Remarks |
| 3:20 pm - 3:40 pm | Richard Kim (Western University, Canada)
"Clinical Relevance of Drug Transporters: Pharmacogenetics and Personalized Medicine" |
| 3:40 pm - 3:45 pm | Discussion |
| 3:45 pm - 3:55 pm | Jean-Michel Bolla (UMR-MD1, France)
"Synthesis and Evaluation of New Polyaminioisoprenyl Antibiotic Enhancers Against Multidrug Resistant Gram-Negative Bacteria" |
| 3:55 pm - 4:00 pm | Discussion |
| 4:00 pm - 5:30 pm | Poster Session |
| 5:30 pm - 7:30 pm | Drug Discovery and Inhibitors and Structure-Based Investigation |
| Discussion Leaders: Akihito Yamaguchi (Osaka University, Japan) and Juerg Dreier (Basilea Pharmaceutica International Ltd., Switzerland) |
| 5:30 pm - 5:40 pm | Diane Borselli (UMR-MD1, France)
"A New Concept to Treat Infections Involving MDR Strains: Cope to Natural Resistance" |
| 5:40 pm - 5:45 pm | Discussion |
| 5:45 pm - 5:55 pm | Vincent Lôme (UMR-MD1, France)
"Multiparametric Profiling for Chemosensitizers Discovery in Gram-Negative Bacteria" |
| 5:55 pm - 6:00 pm | Discussion |
| 6:00 pm - 6:10 pm | Marco Pieroni (University of Parma, Italy)
"Novel Approaches Toward the Eradication of Resistance and Persistent M. tuberculosis Strains" |
| 6:10 pm - 6:15 pm | Discussion |
| 6:15 pm - 6:25 pm | Yunkai Zhang (St. John's University, USA)
"(20S, 24R/S)-Epoxy-12β,25-Dihydroxy-Donmarane-3β-Amine, Novel Semi-Synthetic Octotilol Analogues Reverse ABCB1-Mediated Drug Resistance" |
| 6:25 pm - 6:30 pm | Discussion |
| 6:30 pm - 6:40 pm | Katsuhiko Hayashi (ISIR, Osaka University, Japan)
"Stoichiometry of a Functional AcrA and AcrB Complex" |
| 6:40 pm - 6:45 pm | Discussion |
| 6:45 pm - 6:55 pm | Pranav Puri (University of Amsterdam, The Netherlands)
"Fluorescence Microscopy Approach to Study Assembly and Activity of RND-Type Multidrug Efflux Machine from Escherichia coli " |
| 6:55 pm - 7:00 pm | Discussion |
| 7:00 pm - 7:10 pm | Venkata Krishnan Ramaswamy (University of Cagliari, Italy)
"Computational Study of MexY Efflux Pumps: Insights from Homology Modeling and MD Simulations" |
| 7:10 pm - 7:15 pm | Discussion |
| 7:15 pm - 7:25 pm | Yu Toyoda (The University of Tokyo Hospital, Japan)
"Biomolecular Characterization of Human ABCC11
and Its Clinical Implications" |
| 7:25 pm - 7:30 pm | Discussion |
| 8:00 pm | Dinner |
| Sunday |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:00 am | Biochemical Approaches for Studying Efflux Pumps / Career Panel |
| Career Panel/Round Table Discussion: Senior scientists will meet in a more individual setting with attendees to discuss key topics of what to expect while building and starting your career and build collaborations. During this time, individuals will also have a chance to discuss how their articular field is changing and how to utilize advances made within the field to study multidrug efflux systems. |
| Discussion Leader: Eitan Bibi (Weizmann Institute of Science, Israel) |
| 9:00 am - 9:10 am | Lora Deuitch (Karolinska Institute, Sweden)
"The Specificity and Utility of the ABCG2 Inhibitor Ko143 for PET Imaging" |
| 9:10 am - 9:15 am | Discussion |
| 9:15 am - 9:25 am | Karl Hassan (Macquarie University, Australia)
"Transcriptomics Exposes a Novel Family of Multidrug Efflux Pumps and Reveals the Drug Efflux Potential Hidden in Many Microbial Pathogens" |
| 9:25 am - 9:30 am | Discussion |
| 9:30 am - 9:40 am | Jared Mackenzie (The KwaZulu-Natal Research Institute for Tuberculosis and HIV (K-RITH), South Africa)
"Microchemostat Studies of Mycobacterium tuberculosis Efflux Pumps" |
| 9:40 am - 9:45 am | Discussion |
| 9:45 am - 9:55 am | Mitali Mishra (National Institute of Science Education and Research, India)
"Studies
on acrAB-tolC Multi-Drug Efflux Pump Expression
in Response to pH and Antibiotic Stress in Enterobacter
Isolates" |
| 9:55 am - 10:00 am | Discussion |
| 10:00 am - 11:00 am | Panel Discussion |
| "Starting Your Career and Building Collaborations" |
|
- Eitan Bibi (Weizmann Institute of Science, Israel)
- Verena Keitel (University of Dusseldorf, Germany)
- Deanna Kroetz (University of California, San Francisco, USA)
- Akihito Yamaguchi (Osaka University, Japan)
- Juerg Dreier (Basilea Pharmaceutica International Ltd., Switzerland)
|
| 11:00 am - 12:30 pm | Poster Session |
| Coffee will be served in the poster area from 11:00 am - 11:30 am |
| 12:30 pm | Lunch |
| 1:30 pm - 2:30 pm | Physiological Importance and Relevance / Keynote Session |
| Discussion Leader: Deanna Kroetz (University of California, San Francisco, USA) |
| 1:30 pm - 1:40 pm | Dinesh Fernando (University of Manitoba, Canada)
"Acinetobacter baumannii ATCC 17978 Exposed to Triclosan Causes Increase in Biofilm Formation, Motility, and Decreased Susceptibility to Multiple Antibiotics" |
| 1:40 pm - 1:45 pm | Discussion |
| 1:45 pm - 1:55 pm | Jon Weeks (University of Oklahoma, USA)
"Continuous Versus Discontinuous Assays for Uptake and Efflux of Compounds in Pseudomonsa aeruginosa" |
| 1:55 pm - 2:00 pm | Discussion |
| 2:00 pm - 2:20 pm | Klaas Pos (Goethe University Frankfurt, Germany)
"Mechanisms and Architecture of Multidrug Efflux: Coupling Proton-Relay to Drug Binding of RND-Type Transporters" |
| 2:20 pm - 2:25 pm | Discussion |
| 2:25 pm - 2:30 pm | Closing Remarks |
| 2:30 pm - 3:00 pm | Evaluation Period |
| Fill in GRS Evaluation Forms |
| 3:00 pm | Seminar Concludes |
