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Multi-Drug Efflux Systems (GRS)

Gordon Research Seminar

Diverse Functions and Unifying Themes Within Multi-Drug Efflux Pumps in Global Health and Disease

April 26 - 27, 2025

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Multi-Drug Efflux Systems GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2025 GRS on Multi-Drug Efflux Systems will include a diverse cohort of young scientists from across the globe to facilitate the exchange of ideas, generate partnerships for future endeavors, and foster a culture of collaboration across disciplines. Topics for this year's Multi-Drug Efflux Systems GRS include Advanced Methods in Structural Biology (CryoEM, X-ray Crystallography, NMR), Computational Modeling (Artificial Intelligence, Multi-Omics, Machine Learning), Modern Approaches to Drug Design (Insights into Drug Discovery and Development), and Molecular Mechanisms Driving Multi-Drug Efflux (Eukaryotic and Prokaryotic Systems).

Related Meeting

This GRS will be held in conjunction with the "Multi-Drug Efflux Systems" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm	Structure-Function Insights on Mechanisms of Drug Efflux Pumps Discussion Leader:
3:15 pm - 3:25 pm	"Structural Insights into Anaerobic-Based Multidrug Resistance by the Efflux Pump MdtF"
3:25 pm - 3:30 pm	Discussion
3:30 pm - 3:40 pm	"Structural Basis for the Transport and Regulation Mechanism of Multidrug Transporter MRP2"
3:40 pm - 3:45 pm	Discussion
3:45 pm - 3:55 pm	"Reconstitution and Structural Characterization of the MacAB-TolC Efflux Pump Complex in Escherichia Coli: The Challenges of Working with Protein Complexes"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Integrative Approaches to Efflux Pump Research Discussion Leader:
5:30 pm - 5:40 pm	"Elucidating Proton Transport and Energisation in the Multidrug Tripartite Efflux Pump AcrAB-TolC"
5:40 pm - 5:45 pm	Discussion
5:45 pm - 5:55 pm	"Bioinformatic Analysis Reveals the Association between Bacterial Morphology and Antibiotic Resistance Using Light Microscopy with Deep Learning"
5:55 pm - 6:00 pm	Discussion
6:00 pm - 6:10 pm	"QAC Efflux Pumps in Staphylococci: Threat and Quest for Inhibitors"
6:10 pm - 6:15 pm	Discussion
6:15 pm - 6:25 pm	"Involvement of Metal Transporters of Mycobacterium Smegmatis and Mycobacterium Tuberculosis in Exerting Intrinsic Resistance Towards Structurally Unrelated Antibiotics"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:45 pm	General Discussion
6:45 pm - 6:55 pm	"The Molecular Basis of Polyspecificity and Efficiency in a Multidrug Efflux Pump"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"Plant-Based Indoles as Efflux Pump Inhibitors to Counteract Antimicrobial Resistance"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Conformational Plasticity of P-Glycoprotein and its Modulation by Verapamil"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Targeting Drug Efflux Pumps in Global Health and Disease Discussion Leader:
9:00 am - 9:15 am	"Lipid Regulation of the Lipid/Multidrug ABC Exporter MsbA"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Renoprotective Mechanisms of Melatonin"
9:35 am - 9:40 am	Discussion
9:40 am - 10:00 am	General Discussion
10:00 am - 10:15 am	"Repurposing the CF Drug Ivacaftor as an Efflux Pump Inhibitor to Reduce Resistance and Virulence in Pseudomonas Aeruginosa"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"Redundancy and Hierarchy of Efflux Systems in Escherichia Coli"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"Ligand-Modulated Conformational Dynamics of the Multidrug Transporter LmrP Revealed by Single-Molecule Fluorescence"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Effective Mentorship, Communication, and Networking Discussion Leaders: and
1:30 pm - 2:10 pm	Panel Discussion Stories of Effective Mentorship, Communication, and Networking in Research Science
2:10 pm - 2:30 pm	General Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

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Conference History Multi-Drug Efflux Systems

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