Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
What's New in Calcium Channels Structure?
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"Structural Studies of RyR1 Gating"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Pore Architecture and Gating Mechanism of TRIC Channels"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Assembly
and Maintenance of the Triad/Dyad
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Role of BIN1 in DHPR Traffic and Regulation of Dyad Associated Microdomains"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Mechanisms of Triad Formation and Nuclear Positioning in Skeletal Muscle"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Microtubule Modulation of Cardiomyocyte Contraction"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
"Junctophilin-2 and Cardiac T-Tubule Organization"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Stac3 Enhanced Expression of Human CaV1.1 in Xenopus Oocytes to Characterize HypoPP Mutant Channels"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Triadin Trafficking in Sarcoplasmic Reticulum Sub-Domains"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Secondary Alteration of EC Coupling in Myopathies and Cardiac Diseases
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"E-C Coupling and Microdomain Signaling in Ischemic Cardiomyopathy"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Regulation of SERCA Pump Activity in SEPN1-Related Myopathies"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Sarcolemma Integrity and Muscle Dysfunction in Dystrophic Muscle"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"The Voltage-Gated Calcium Channel Is the Ca2+ Sensor of Cardiac Contraction"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Convergent/Divergent Mechanisms and Phenotypes in Related Disorders
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"MH and Exertional Heat Stroke"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Molecular and Physiological Mechanisms for QRS- and QT-Interval Prolongation in Mice with Cardiac Expression of Expanded CUG-Repeat mRNA"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Diverse Arrhythmogenic Mechanisms in CPVT1"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:20 am
"Functional Cross Talk Between the Dihydropyridine Receptor and Pannexin 1 in Skeletal Muscle"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Ablation of the RyR2-Ser2030 Phosphorylation Site Limits Changes in RyR2 Sensitivity During β-Adrenergic Stimulation"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"Novel CPVT Mutations in RyR2 with Altered Response to CICR Ligand"
11:50 am - 11:55 am
Discussion
11:55 am - 12:00 pm
General Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ongoing Clinical Trials for Myopathies with EC Coupling Alteration
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"AAV Vectors as Potential Therapeutics for Duchenne Muscular Dystrophy"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Update on N-Acetylcysteine Trial in RYR1-Related Myopathy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Probing the Role of PKA and CaMKII Phosphorylation on the Cardiac Ryanodine Receptor"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"High-Throughput Screening to Discover Allosteric Inhibitors of Leaky RyR2 for Heart Failure and Arrhythmia Therapy"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Future Directions for Therapeutic Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"CRISPR/Cas9 for Muscle Disease"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Excitation-Contraction Coupling Plasticity in Pluripotent Stem Cell-Derived Cardiac Myocytes"
10:10 am - 10:30 am
Discussion
10:30 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
"Preventing Ca Evoked Arrhythmias with Ryanodine Receptor Targeted Drugs"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Enhanced Neuronal Na+ Channel Activity Associated with Arrhythmogenic Calmodulin Mutations"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Myotubular Myopathy and Excitation Contraction Coupling: From Pathomechanism(s) to Therapy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Pivotal Role of Mitochondria
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Oxidative Stress and Mitochondria in Cardiomyocytes"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Determining Efficacy of Therapy to Reverse Duchenne Muscular Dystrophy Cardiomyopathy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Regulation of Metabolism in Individual Mitochondria During E-C Coupling"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:50 pm
"Excitation-Metabolism Coupling in Skeletal Muscle"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Identifying Proteins Essential for Skeletal-Type EC Coupling Calcium Release"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Phospholamban Modification to Rescue Arrhythmias Related to RyR2 Phosphorylation"
10:30 am - 10:40 am
Discussion
10:40 am - 11:10 am
Coffee Break
11:10 am - 11:25 am
"Role of MG 23 in Skeletal Muscle"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Chimeric Approach Reveals the Domains of the STAC3/CaV1.1 Interaction"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Identification and Characterization of Mutations in the CASQ1 Gene in Patients with Tubular Aggregate Myopathy (TAM)"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Physiological
and Pathophysiological Calcium Entry
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Functional Effect of ORAI1 Mutations in Muscle Diseases"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Exercise-Dependent Formation of New SR-TT Junctions Which Promotes Increased STIM1-Orai1 Colocalization"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:25 pm
"Role of Calcium Flux Through DHPR"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"What Structure Tells You if You Look"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure