Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Advances in RyR Post-Translation Modification and Clustering
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:10 pm
"RyR2 Rearrangement Within the Dyadic Cleft: Causes and Consequences"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Regulation of RyR by SPEG"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:10 pm
"Nitration Attack on RyRs"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"CaMKII Increases Susceptibility to Cardiac Alternans"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Protein-Protein Allosterics and Their Role in ECC
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Molecular Transitions that Initiate EC Coupling in Heart and Muscle"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Allosteric Regulation of Ryanodine Receptors and TRIC Channels"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Sodium Channel Coupling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Structural Analysis of Recombinant Ryanodine Receptors by Cryo-EM"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"The Cardiac Ryanodine Receptor Phosphorylation Hot Spot Embraces PKA in a Phosphorylation-Dependent Manner"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Ion Homeostasis Control in Muscle and Disease
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Junctional Membrane Calcium Dynamics in Skeletal Muscle Fibres"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"RyR Modification in Skeletal and Cardiac Muscle"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Substitution of Asn by Asp at Entrance of the Pore Region Conditions Ion Selectivity of Voltage-Gated Ca2+ Channels in Skeletal Muscle from a Non-Ca2+ Conducting Dihydropyridine Receptor Mouse Model"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Unravelling Molecular Mechanisms of Skeletal Excitation-Contraction Coupling Using NMR "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Malignant Hyperthermia and Muscle Disease Mutations
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Unraveling the Genetics of Malignant Hyperthermia"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Metabolomic Derangements in Patients with Malignant Hyperthermia"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Examining Muscle Dysfunction in a Mouse Model of Human CSQ1-Linked Myopathy"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Caffeine or Halothane? Discordant Muscle Responses Associated with Divergent Calcium Management in MH Patients"
11:30 am - 11:40 am
Discussion
11:40 am - 11:55 am
"Mouse Model of Severe Recessive RYR1-Related Myopathy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
ECC and Therapeutic Discovery Beyond Muscle
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"From Bone-Muscle Crosstalk to New Approaches to Understand, Diagnose and Treat the Musculoskeletal Unit"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Role of Skeletal Muscle in ALS Pathogenesis and Progression"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Ryanodine Receptor Calcium Release Channels in Alzheimer's Disease"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Transverse Tubule Remodeling Enhances Orai1-Dependent Ca2+ Entry in Skeletal Muscle"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Calmodulin Functions in Muscle Health and Disease
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"The Mutation Spectrum in Calmodulin: A Genetic Tale"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Calmodulinopathy: Chameleon Among Inherited Arrhythmia Disorders"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"The Many Faces of Calmodulin Mutations"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Tuning CaM Signaling to CaV Channels by Stac Proteins"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"The F141L Mutation in Human Calmodulin Disrupts the Structure and Leads to Misregulation of a Cardiac Voltage-Gated Calcium Channel"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Fret-Based Trilateration Resolves Distinct Structural States and Transitions of Calmodulin Bound to RyR "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
RyRs and CaVs: Targets for Small Molecules and Proteins
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"The Calcin Family of Ryanodine Receptor Ligands: The Hidden Salutary Effect of Scorpion Toxins"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Structural Biology Drives Drug Discovery Targeting the Pathological Leak of RyR Channels"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Identification of Novel RyR1 Inhibitors by High-Throughput Screening with ER Ca2+ Measurement"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Mechanisms of Enhanced Heat Sensitivity Associated RyR1-MH Mutations"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Novel Therapeutic Directions for ECC Disorders
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"RyR Structure Provides Clues for Therapeutics"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"RyR1 Deficiency, a New Mouse Model of Core Myopathy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"RYR1 NAC Trial Results and Beyond: First and Future Clinical Trials for RYR1-Related Disorders"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Exercise Prevents Formation of Tubular Aggregates in Ageing Skeletal Muscle Fibers"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Mitochondrial Nanotunnels Are Specific to Cardiac Myocytes and Are Inducible"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Increase in RyR2-Mediated Ca2+ Leak Promotes Mito-ROS Production Without Changing Mitochondrial Ca2+ Content in Ventricular Cardiomyoytes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Essential Components for E-C Coupling
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Molecular Tuning of CaV1.1 for Its Specific Functions in Skeletal Muscle"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"The (Ir)relevance of DHPR Calcium Influx in Skeletal Muscle"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:50 pm
"Dissecting the Molecular Interactions Underlying EC-Coupling Calcium Release in Skeletal Muscle"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure