At the Leading Edge: Integrative Insights in Muscle EC Coupling

EC coupling is the fundamental mechanism by which action potentials are converted into contractile force in muscle cells. To advance the leading edge of EC coupling research and to perpetuate the ongoing excellence in the field, the EC Coupling GRS aims to offer an unparalleled friendly and inclusive environment for young investigators, the future of the field, to discover unique scientific opportunities and to establish prolific international research collaborations. The 2025 GRS will emphasize current ideas and integrative insights on the inner mechanistic workings of EC coupling in skeletal, cardiac, and smooth muscles. The comprehensive range of topics will include molecular structure and function, regulation at the subcellular level, breakthroughs in understanding of mechanisms underlying physiology and disease, and next generation strategies for translational research and therapy. The Seminar features three core thematic scientific sessions in which early career Discussion Leaders and Speakers selected from submitted abstracts will present and discuss their most recent scientific research findings. As in previous installments, the 2025 GRS will also feature a Mentoring Component in which established scientists will share their vision for the future of the field and address key questions on career development and funding success pertinent to early stage scientists.