Sunday Evening
Control of replication fidelity: Role of DNA polymerases
- Session Chair: Sam Wilson
- Discussion Leader: Myron Goodman - Biochemical basis of DNA replication fidelity
- Chris Lawrence - Yeast DNA polymerase zeta
- Elizabeth Snow - Effects of carcinogenic metal ions on DNA polymerase kinetics andfidelity
- Roger Woodgate - Structural insights into the activities of the UmuD' mutagenesis protein
Monday Morning:
Role of mismatch repair in modulating mutagenesis and chromosomal stability
- Session Chair: Paul Modrich - Mechanisms of mismatch repair
- Discussion Leader: Miroslav Radman
- Tom Kunkel - Studies of DNA replicationfidelity and mismatch repair
- Michael Liskay - Mismatch repair in yeast and mice
- Josef Jiricny - Mismatch binding activities in human cells
Monday Evening
Endogenous sources of mutagenic lesions and their repair
- Session Chair: Tomas Lindahl
- Discussion Leader: Susan Wallace
- Priscilla Cooper - Role of XPG and CSB in repair of oxidative base damage
- RoeISchaaper - Spontaneous mutations in E. coli
Tuesday Morning:
Role of excision repair in modulating cell survival and mutagenesis
- Session Chair: Richard Wood - Nucleotide excision repair proteins in mammalian cells
- Jim Ford - Role of p53 in cellular survival and DNA repair in UV irradiated human cells
- Kiyoji Tanaka - Role of the XPA protein in nucleotide excision repair
- Eugenia Dogliotti - What are the factors that determine strand bias in mammalian mutational spectra?
Tuesday Evening:
Sequence-context role in mutagenic specificity
- Session Chair: Lynn Ripley
- Discussion Leader: Robert Puchs - Different strategies of replication of a damaged DNA molecule
- Veronica Maher - Factors that affect mutation spectra
- Sylvia Tornaletti - Effect of sequence context on efficiency of excision repair
Wednesday Morning:
Recombination mechanisms and hyperinutation in the immune system
- Session Chair: Steve West - Molecular interactions in genetic recombination and recombinational repair
- Discussion Leader: Nancy Maizels - Immunoglobulin heavy chain class switch recombination
- Ursula Storb - Somatic hypermutation of immunoglobulin genes is linked to initiation of transcription
- Susan Jinks-Robertson - Mismatch repair proteins regulate homologous recombination in yeast
- Justin Courcelle - Role of recF in recombination and/or replication restart
Wednesday Evening:
Transgenic systems for studying DNA lesion processing and mutagenesis
- Session Chair: Leona Samson - Modulating DNA alkylation repair in mice
- George Douglas- - Mutagenesis in germ cells and spermatozoa of lacZ transgenic mice
- Mutsuo Sekiguchi - Alkylation carcinogenesis as studied with methyltransferase gene-targeted mice
- Gert Weeda - Transgenic mice as modelfor DNA repair-transcription syndromes
Thursday Morning:
Mutagenesis in non-dividing cells
- Session Chair: Bernard Strauss - Why do we believe that mutation occurs (only) in dividing cells?
- Discussion Leader: Susan Rosenberg - Molecular handles on adaptive mutation
- Patricia Foster - Mechanisms of adaptive mutation in E. Coli
- Steven Sommer - Molecular epidemiology of mutation in the human factor IX gene
Thursday evening:
Relationships between mutation and cancer, - Special Discussion Session
- Discussion leader: Larry Loeb
- Discussant: Bryn Bridges
- This session, following the banquet, will depart from the usual format of multiple presentations. Rather, it will be a guided discussion session focussed upon the following four questions:
- What is the evidence that mutations are causative in the initiation of tumors?
- Do diagnostic mutations in a tumor indicate that an agent that causes these mutations is responsible for initiating the malignant process?
- Are the multiple mutations observed in tumors the consequence of a mutator phenotype?
- What are the contributions of spontaneous endogenous processes to the development of cancer?
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