Chair: Thomas Kunkel, NIEHS
Discussion Leader: Linda Reha-Krantz, University of Alberta

• Sylvie Doublié, Harvard Medical School - Caught in the act: crystal structure of the T7 replication complex
• Lorena Beese, Duke University - Observing replication and mutagenesis in a catalytically active DNA polymerase crystal
• William Konigsberg, Yale University - DNA polymerase-substrate encounters of the third kind: Effect of ribonucleotide residues on excision rates when DNA polymerases are in the editing mode

Chair: Myron Goodman, University of Southern California
Discussion Leader: Arthur Grollman, SUNY Stony Brook

• Michael O'Donnell, Rockefeller University - Inner workings of the machine that assembles polymerase clamps onto DNA
• Joann Sweasy, Yale University School of Medicine - Fidelity mutants of DNA polymerase beta
• Eric Kool, University of Rochester - How important are hydrogen bonds in replication and mutagenesis?

Chair: Paul Modrich, Duke University
Discussion Leader: Josef Jiricny, University of Zürich

• Paul Modrich - Mechanisms of mismatch repair in E. coli and human cells
• Richard Kolodner, Ludwig Institute for Cancer Research at UC - San Diego - Multiple mehanisms of mutation suppression
• Andrew Buermeyer, Oregon Health Sciences Center - Role of Mammalian MutL Homologs in DNA Mismatch Repair

Chair: Richard Cunningham, SUNY - Albany
Discussion Leader: Leona Samson, Harvard School of Public Health

• John Tainer, Scripps Research Institute - Initation Steps of Base-Excision Repair Revealed by Enzyme-DNA Co-crystal Structures
• Gregory Verdine, Harvard University - Mechanistic and Structural Studies on Repair of Damaged DNA Bases
• Samuel Wilson, NIEHS - Rate-limiting steps during base excision repair of endogeneous DNA lesions

Chair: Bernard Weiss, University of Michigan
Discussion Leader: Lawrence Loeb, University of Washington

• Bruce Demple, Harvard School of Public Health - Oxidative stress responses and the prevention of genetic damage
• Shoshy Altuvia, Hebrew University - Bacterial response to oxidative stress: Role of a small RNA as a global regulator and antimutator
• Miroslav Radman, Institut Jacques Monod - Oxidative damage cuases high error rates of DNA replication and transcription/translation processes in aging bacterial colonies

Chair: Steven West, ICRF
Discussion Leader: Sue Jinks-Robertson, Emory University

• Scott Morrical, University of Vermont - Recombinase and Helicase Loading Mechanisms in T4 Recombination
• Patrick Sung, University of Texas - Enzymology of Heteroduplex DNA Formation
• Junjie Chen, Dana Farber Cancer Institute - Breast Cancer Susceptibility genes and DNA repair

Chair: Stephen Jackson, Wellcome/CRC
Discussion Leader: Susan Lees-Miller, University of Calgary

• Steve Jackson - The detection, signalling and repair of DNA double-strand breaks
• Nancy Kleckner, Harvard University - IHF modulation of Tn10/IS10 transposition in vitro and in vivo: Sensory transduction of supercoiling status via a proposed protein/DNA molecular spring
• James Haber, Brandeis University - Expansions and contractions of repeated sequences induced during gene conversion repair of double-strand breaks

Chair and Discussion Leader: Philip Hanawalt, Stanford University

• Priscilla Cooper, University of California, Berkeley - Intersection of Base and Nucleotide Excision Pathways in Transcription-Coupled Repair of Oxidative Damage
• Frank Jirik, University of British Columbia - Lymphomas arising from the thymi of mismatch repair-deficient mice show hypermutation of a lacI transgenic reporter
• Graham Walker, MIT - Inducible E. coli proteins involved in mutagenesis and control of cell cycle in response to DNA damage
• Ted Weinert, University of Arizona - Mysteries of Checkpoint Control in Yeast

Chair and Discussion Leader: Lynn Ripley, UMDNJ

• Lynn Ripley - Genomics and Spontaneous Mutation Specificity: A demonstration that combinatorial approaches do identify novel hotspots and point to the mechanism
• Cynthia McMurray, Mayo Clinic - Mutational mechanisms for DNA instability in human disease
• Dmitry A. Gordenin, NIEHS - Yeast models of human ARMs (At-Risk Motifs)