Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Synthesis
Enabled Biological Studies |
| Discussion Leader: Joanne Harvey (Victoria University of Wellington, New Zealand) |
7:40 pm - 8:10 pm | Emmanuel Theodorakis (University of California, San Diego, USA) "Natural Products: From Flask to Cell" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:40 pm | Corinna Schindler (University of Michigan, USA) "New Carbocyclization Reactions for the Synthesis of Complex Molecules" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Armen Zakarian (University of California, Santa Barbara, USA) "Recent Advances in Natural Products Synthesis and Biological Studies" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Technology
Driven Chemical Synthesis |
| Discussion Leader: Arun Thottumkara (Revolution Medicines, USA) |
9:00 am - 9:30 am | Timothy Jamison (Massachusetts Institute of Technology, USA) "Continuous Flow Multistep Synthesis" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Alexander Godfrey (Eli Lilly & Co., USA) "Automated Synthesis: An Invitation to the Lab of the Future" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Peter Seeberger (Max Planck Institute of Colloids and Interfaces, Germany) "From Automated Glycan Assembly to Synthetic Vaccines Against Infectious Diseases" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Ian Davies (Merck Research Laboratories, USA) "Big Data and Its Impact on the Synthetic Chemistry Skillset" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Antibiotic Discovery |
| Discussion Leader: Marcy Balunas (University of Connecticut, USA) |
7:30 pm - 8:00 pm | Christian Melander (North Carolina State University, USA) "Adjunctive Approaches to Break Antibiotic Resistance" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Stefan Koenig (Genentech, Inc., USA) "Arming S. aureus-Targeting Antibody-Antibiotic Conjugates (AACs) Through Process Chemistry" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Elizabeth Nolan (Massachusetts Institute of Technology, USA) "Siderophores, Antibiotics and the Microbiota" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Next Generation Drug Discovery |
| Discussion Leader: Leslie Aldrich (University of Illinois at Chicago, USA) |
9:00 am - 9:25 am | Paul Fatheree (Theravance, USA) "The Chemistry and Preclinical Biology of Novel Polymyxin Antibacterials for the Treatment of Gram Negative Infections" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Denise Barrault (National Phenotypic Screening Centre, United Kingdom) "Public-Private Partnerships that Drive Innovation in Drug Discovery" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Stephen Frye (University of North Carolina at Chapel Hill, USA) "Chemical Biology of Methyl Lysine" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Hendrik Luesch (University of Florida, USA) "Multilevel Characterization of Natural Products from Marine Cyanobacteria" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemistry of the Human Microbiome |
| Discussion Leader: Sean Davies (Vanderbilt University, USA) |
7:30 pm - 8:00 pm | Michael Fischbach (University of California, San Francisco, USA) "Small Molecules from the Human Microbiota" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Emily Balskus (Harvard University, USA) "Gut Reactions: Chemical Discovery and the Human Microbiota" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Pieter Dorrestein (University of California, San Diego, USA) "Global Natural Products Social Molecular Networking in Space and Time" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Strategies and Tactics for Chemical Synthesis |
| Discussion Leader: Joshua Pierce (North Carolina State University, USA) |
9:00 am - 9:30 am | Patrick Harran (University of California, Los Angeles, USA) "Crafting Macrocycles with Designed Scaffolding" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Rendy Kartika (Louisiana State University, USA) "New Chemistries with Oxyallyl Cations" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:40 am | Coffee Break |
10:40 am - 11:10 am | Paul Floreancig (University of Pittsburgh, USA) "Transposition Reactions for Increasing Molecular Complexity" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:50 am | Toshiaki Sunazuka (The Kitasato Institute, Kitasato University, Japan) "Synthetic Strategy for Construction of Unique Polycyclic Natural Products" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:30 pm | Poster Previews |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Biosynthesis-Inspired Technologies |
| Discussion Leader: Wendy Kelly (Georgia Institute of Technology, USA) |
7:30 pm - 8:00 pm | Adrian Keatinge-Clay (University of Texas at Austin, USA) "Visualizing and Harnessing Polyketide Assembly Lines" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Michael Burkart (University of California, San Diego, USA) "Directing Natural Product Biosynthesis in the Acetate Pathway" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Michelle Chang (University of California, Berkeley, USA) "Synthetic Biology Approaches to New Fluorine Chemistry" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Drug Discovery Platforms for Cancer and Rare Diseases |
| Discussion Leader: Michelle Garnsey (Pfizer, Inc., USA) |
9:00 am - 9:30 am | Andres Francesch (Pharmamar, Spain) "Discovery and Development of Marine Anticancer Drugs" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Roger Linington (Simon Fraser University, Canada) "Towards Universal Compound Discovery: Applications of the Natural Products Atlas" |
10:10 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:05 am | Selected from Poster Abstracts: Alexander Grenning (University of Florida, USA) "A Tunable Terpenoid Synthesis Strategy" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:40 am | Qiu Wang (Duke University, USA) "Leveraging Chemistry for Biology and Therapy: New Amination Strategies to Access Biologically Important Molecules" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:20 pm | Mark O'Neil-Johnson (Sequoia Sciences, Inc., USA) "Has Combinatorial Chemistry Hurt Us All?" |
12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: State-of-the-Art Chemistry and Biology |
| Discussion Leader: Jon Rainier (University of Utah, USA) |
7:30 pm - 8:00 pm | Gabriela Chiosis (Memorial Sloan Kettering Cancer Center, USA) "The Chaperome as a Target in Cancer" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Stephen Moss (Isomerase Therapeutics, United Kingdom) "Natural Product Drug Discovery Through Biosynthetic Engineering" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Thomas Hoye (University of Minnesota, USA) "Natural Product vis-à-vis Benzyne Chemistry" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |