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Natural Products and Bioactive Compounds

Gordon Research Conference

Natural Products: Diversity and Integration

July 28 - August 2, 2024

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Chair Dirk Trauner

Vice Chairs Cheryl Hayward and David Sarlah

Contact Chairs

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Application Information

Applications for this meeting must be submitted by June 30, 2024. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the conference chair if more seats become available due to cancellations.

Conference Description

The Natural Products and Bioactive Compounds GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Natural products have played a critical role in the development of synthetic and structural chemistry, have been indispensable for the elucidation of biological pathways, e.g. in neuroscience and immunology, and have posed fascinating biosynthetic questions. Small metabolites play crucial roles within and in between organisms, i.e., in physiology and ecology. A large proportion of clinically used drugs are either natural product themselves or are natural-product derived. As such, natural products continue to drive new developments in a wide variety of fields, ranging from computational chemistry, synthetic methodology and synthetic design, to enzymology, molecular biology, structural biology, genome mining and computational biology. The conference will feature talks and discussions on these topics, reflecting the diversity, vibrancy, and integrating power of natural products research.

Related Meeting

This GRC will be held in conjunction with the "Natural Products and Bioactive Compounds" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: The Total Synthesis of Complex Natural Products Discussion Leader: Alex Schuppe (Vanderbilt University, United States)
7:40 pm - 8:20 pm	Darren Dixon (University of Oxford, United Kingdom) "Catalyst Control in Complex Natural Product Synthesis"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	Masayuki Inoue (The University of Tokyo, Japan) "Total Synthesis of Highly Oxygenated Natural Products"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Rising Stars in Natural Products Chemistry Discussion Leader: James Leahy (University of South Florida, United States)
9:00 am - 9:30 am	Marvin Parasram (New York University, United States) "Anaerobic Heteroatom Transfer Reactions Promoted by Photoexcited 1,3-Dipoles"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Lara Malins (Australian National University, Australia) "Advances in Late-Stage Peptide Modification Chemistry: Inspiration from Nature"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	Sunkyu Han (KAIST, South Korea) "The Chemistry of Securinega Alkaloids"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	Tanja Gaich (University of Konstanz, Germany) "The Devil Is in the Details: Total Syntheses of Cyclotaxanes"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Emily Mevers (Virginia Tech, United States) and Elizabeth Parkinson (Purdue University, United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Medicinal and Process Chemistry of Natural Products and Bioactive Compounds Discussion Leader: Joel Smith (Florida State University, United States)
7:30 pm - 8:00 pm	Werngard Czechtizky (AstraZeneca, Sweden) "New Modalities Enabling Target Validation"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Kristine Frank (AbbVie, United States) "A Med Chem Tale of Making Lemonade from Lemons"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Michael Herr (Pfizer Global Research and Development, United States) "Process Development of CDK2 Selective Inhibitor PF-07104091"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Peptides, Proteins, and Their Modifications Discussion Leader: Paramjit Arora (New York University, United States)
9:00 am - 9:30 am	Christina Schroeder (Genentech, United States) "Discovery and Development of Disulfide Constrained Peptides"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Mandë Holford (Hunter College, City University of New York, United States) "From Snails To Cephalopods: A Journey of Molluscan Venom Discovery"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	Christina Woo (Harvard University, United States) "Chemistry and Biology of the C-terminal Cyclic Imide Modification"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	Nina Hartrampf (University of Zurich, Switzerland) "New Methods for the Chemical Synthesis of Post-Translationally Modified Peptides and Proteins"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Lipids, Carbohydrates, Cell Walls, and Their Modifications Discussion Leader: Tania Lupoli (New York University, United States)
7:30 pm - 8:00 pm	Niki Patel (Merck & Co., United States) "A Collaborative Total Synthesis of Darobactin"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Alison Wendlandt (Massachusetts Institute of Technology, United States) "Emergent Selectivity in Complex Stereoarrays"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Suzanne Walker (Harvard Medical School, United States) "Targeting Diacylglycerol Kinase to Overcome MRSA"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Novel Synthetic Strategies and Methodologies Discussion Leader: Jose Roque (Princeton University, United States)
9:00 am - 9:30 am	Guangbin Dong (University of Chicago, United States) "Deconstructive Homologation of Ethers and Amides"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Song Lin (Cornell University, United States) "Enantioselective Catalysis and Electrocatalysis of Radical Reactions"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	Pauline Chiu (The University of Hong Kong, Hong Kong SAR China) "Synthetic Studies Toward Tubingensin B"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	Ramesh Giri (Pennsylvania State University, United States) "Difunctionalization of Alkenes with Carbon Sources"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Strategies and Tactics for Complex Natural Product Total Synthesis Discussion Leader: Daria Kim (Vanderbilt University, United States)
7:30 pm - 8:00 pm	Thomas Magauer (University of Innsbruck, Austria) "Curiosity, Challenges and Discovery in Natural Product Synthesis"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:40 pm	Joshua Pierce (NC State University, United States) "Adventures in the Total Synthesis and Chemical Microbiology of Marine Natural Products"
8:40 pm - 8:50 pm	Discussion
8:50 pm - 9:20 pm	Corinna Schindler (University of Michigan, United States) "Overcoming Limitations in Visible Light Mediated Aza Paterno-Buchi Reactions"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Genomes and Chemical Connectomes Discussion Leader: Monica McCallum (University of Pennsylvania, United States)
9:00 am - 9:30 am	Mohammad Seyedsayamdost (Princeton University, United States) "Genome Mining for Selenometabolites"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	Nadine Ziemert (University of Tübingen, Germany) "Computational Genomics to Unravel the Diversity and Distribution of Bacterial Natural Products"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	Eric Schmidt (University of Utah, United States) "Biosynthesis of Elaborate Polyketides Encoded by Animal Genomes"
11:20 am - 11:30 am	Discussion
11:30 am - 12:00 pm	Rolf Müller (Helmholtz Centre for Infection Research, Germany) "Approaches Towards Innovative Anti-Infectives From Microbes"
12:00 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: The Origin and Meaning of Natural Products Discussion Leader: Makeda Tekle-Smith (Columbia University, United States)
7:30 pm - 8:15 pm	Squire Booker (Pennsylvania State University, United States) "Radical Mechanisms for Biological Methylation"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:15 pm	Jon Clardy (Harvard Medical School, United States) "Mining Human-Associated Bacteria for Biologically Active Small Molecules"
9:15 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Conference Links

Conference History Natural Products and Bioactive Compounds (GRS) Contribute Financially to This Conference

Conference Fees

Similar Conferences

Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Diversity Funding

Financial assistance is available for qualified applicants through the GRC Carl Storm Underrepresented Minority Fellowship Program. This program provides a grant to underrepresented minority graduate students, postdocs, faculty and scientists to help fund their attendance at their first GRC meeting. Learn more.

Registration Fees

Conferee Single Room:

$965.00

Conferee Shared Room:

$915.00

Conferee Off-Site:

$765.00

Guest Single Room:

$775.00

Guest Shared Room:

$725.00

Guest Off-Site:

$575.00

Child 4-12 yrs Shared Room:

$363.00

Child 4-12 yrs Off-Site:

$288.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Bus Arriving:

$58.00

Bus Departing:

$58.00

Additional Fee Info

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