Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Emerging Topics in Neuroimmunology
This session will feature a keynote speaker, Nobel Laureate, Prof. Mario Capecchi.
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:15 pm
"The Presence of at Least Two Ontogenetic Distinct Microglia Populations in the Mammalian Brain"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Persistent Tri-Glial Dysfunction in Methotrexate Chemotherapy-Induced Neurological Impairment"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Power of ONE: Immunology in the Age of Single Cell Genomics"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Neuroimmunology Beyond Microglia
9:00 am - 9:20 am
"Modulation of Neuroinflammation via Lymphatic Endothelial Growth Factor Pathways"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Reversing Behavioral Abnormalities in Mice Exposed to Maternal Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Meningeal Lymphangiogenesis Effect on Malignancy of Glioblastoma"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Mobilization of Meningeal Immune Cells Using Integrin Signaling"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Setting Some Boundaries: Neurodegeneration vs. Neuroinflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Saving the Synapse: MHC Class I, Pruning and Plasticity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Systems Level Analysis of the Response to CNS Injury: Revealing Targets for Neuroprotection and Regeneration"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Deciphering the Cellular Landscape of the Alzheimer's by Single Nucleus RNA-Seq"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Microglia and Other Glia Functions During Homeostasis and in Neurological Diseases
7:30 pm - 7:50 pm
"Impact of TREM2 in Microglia Metabolism"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"The Myeloid Side of the Brain"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Environmental Control of CNS-Resident Cells"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Impact of Immune Cells in Alzheimer's Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immune Effects on Brain Function
9:00 am - 9:20 am
"How Does Inflammation Alter Antigen Sampling from the Brain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Microglia Differentiation In Vivo and In Vitro "
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Microglial GPR56 Regulates Developmental Synaptic Pruning"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"DNA Damage Surveillance by the Innate Immune System in CNS Health and Disease"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Microglia Mediate Masculinization of the Brain via Multiple Mechanisms"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Cytokine Control of Brain Macrophage Development"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Transcriptional Programs Underlying Astrocyte-Driven CNS Inflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Brain Localized Inflammation Leads to Peripheral Tissue-Specific Macrophage Infiltration"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunity and Neurodegenerative Diseases
Session in memory of Ben Barres.
7:30 pm - 7:50 pm
"How Microglia Dysfunction Contributes to Tauopathy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Blocking Immune Checkpoint Signaling Pathways for Alzheimer's Disease Immunotherapy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Immune-CNS Crosstalk: A Fine Line Between Injury and Repair"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Brain Vasculature as a Target of Circulatory Factors During Aging"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome-CNS Communication
9:00 am - 9:20 am
"Brain Autoimmunity: Activation Events in Autoimmune T Cells Targeting the CNS"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Control of Neurodevelopmental Disorder by Maternal Bacteria"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"From T Cell Receptor to Antigen: Systems Approaches to Discovering T Cell Antigen(s) in Neurological Diseases"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Oligodendrocyte Precursor Cells Are Co-Opted by the Immune System to Cross-Present Antigen and Mediate Cytotoxicity"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Regulation of Th17 by IL-17: Implications for Autoimmunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Gut-Microbiome-Brain Connections in Neurodevelopment"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Sex Specific Differences in Microglia Response to Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Microbiota-Derived Short-Chain Fatty Acids Promote Amyloid Deposition via Microglial Activation in an AD Mouse Model"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
BBB and Other Barriers: Function and Dysfunction
7:30 pm - 7:50 pm
"Fibrinogen in Neurological Diseases: From Mechanisms to Therapies"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Immune Mechanisms Underlying Restoration of CNS Barriers"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Blood-Brain Barrier Structure, Function and Pathology: Implications for Dementia and Alzheimer's Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Developing MRI Markers of Chronic Inflammation in Multiple Sclerosis"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Infections, Immunity and CNS
9:00 am - 9:20 am
"Understanding Microglia State Changes in Development and Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Enteric Neuron Function in Immune-Mediated Intestinal Barrier Protection"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Brain-Bacteria Interface: A Brainless Xenopus laevis Developmental Model Reveals a Role for Brain in Regulating the Early Innate Immune Response"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"CSFR1 Signaling Is Required for Local Restimulation of Antiviral CD8+ T Cells During Viral Encephalitis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Genome-Wide Approaches to Defining Human Microglia Identity and Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"How Much Do We Need to Know About P. falciparum Cerebral Malaria to Treat It"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"CNS Intrinsic Mechanisms Suppressing T Cell Driven Neuroinflammation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"ZBP1 and RIPK3 Induce an Antiviral Metabolic State in Neurons via IRG1"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neuroimmunology Outside of CNS
7:30 pm - 7:50 pm
"Neuro-Immune Regulation of Bacterial Infection at Barrier Sites"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Activating the Brain to Control Immunity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Neuronal Regulation of Innate Lymphocytes"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Progranulin Loss Dysregulates Splenic and Peripheral Blood Immune Cells Populations and May Contribute to Neuroinflammation and Neurodegeneration in Frontotemporal Dementia"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Sensory Neuronal Regulation of Enteric Host Defense Against Salmonella typhimurium "
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure